Search Results - "Kuck, J F"

Moderate caloric restriction delays cataract formation in the Emory mouse by Taylor, A, Zuliani, A M, Hopkins, R E, Dallal, G E, Treglia, P, Kuck, J F, Kuck, K

“…Eye lens senile cataract is a major cause of blindness, affecting the elderly in particular. The etiology of the disorder has been elusive, and attempts to…”
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Near-infrared Fourier transform Raman and conventional Raman studies of calf gamma-crystallins in the lyophilized state and in solution by Chen, W.L., Nie, S.M., Kuck, J.F., Yu, N.T.

“…We present in this report a detailed structural study of calf gamma-crystallins both in the solid state and in solution by the newly developed technique of…”
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Automated Laser-Scanning-Microbeam Fluorescence/Raman Image Analysis of Human Lens with Multichannel Detection: Evidence for Metabolic Production of a Green Fluorophor by Yu, Nai-Teng, Cai, Ming-Zhi, Ho, Deborah Jui-Yuan, John F. R. Kuck

“…A laser-microprobe fluorescence/Raman spectrometer with a 700-channel detector has been constructed and applied to the collection of data on the distribution…”
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Disulfide Bond Formation in the Eye Lens by Yu, Nai-Teng, DeNagel, Diane C., Pruett, P. Leanne, John F. R. Kuck

“…The disposition and disposal of the -SH groups of the lens during aging and cataractogenesis have been investigated by laser Raman spectroscopy as a…”
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Nature and localization of avian lens glycogen by electron microscopy and Raman spectroscopy by Castillo, C.G., Lo, W.K., Kuck, J.F., Yu, N.T.

“…Electron microscopy confirms the presence of a high concentration of glycogen particles in the lens nuclear region of birds of flying habit such as the…”
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Distribution of two metabolically related fluorophors in human lens measured by laser microprobe by Yu, N T, Barron, B C, Kuck, Jr, J F

“…Automated Raman microprobe spectrometry revealed the distribution of a major fluorophor, 3-OH-L-kynurenine-O-beta-glucoside, in human lenses from 0.38 to 71…”
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Oxidative stress on lens and cataract formation: role of light and oxygen by Varma, S D, Chand, D, Sharma, Y R, Kuck, Jr, J F, Richards, R D

“…The mechanism of oxidative damage to the lens through intraocular photochemical generation of superoxide and its derivatization to other oxidants such as…”
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Tryptophan Raman/457.9-nm-excited fluorescence of intact guinea pig lenses in aging and ultraviolet light by Barron, BC, Yu, NT, Kuck, JF, Jr

“…Normal age-matched guinea pig lenses were compared with those exposed to (1) long-term ultraviolet (UV) light (9 months, 353-nm peak) in vivo, and (2)…”
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Proteases in the Emory mouse cataract by Swanson, AA, Davis, RM, Meinhardt, NC, Kuck, KD, Kuck, JF, Jr

“…Exopeptidases identified as dipeptidyl peptidase III and leucine aminopeptidase, and an endopeptidase, prolyl endopeptidase, were found in the Emory Mouse…”
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Resonance Raman detection of a carotenoid in the lens of the deep-sea hatchetfish by Yu, N T, Cai, M Z, Lee, B S, Kuck, Jr, J F, McFall-Ngai, M, Horwitz, J

“…A laser scanning micro-probe has been used to elicit resonance Raman signals from frozen sections of the lens of the deep-sea hatchetfish, Argyropelecus…”
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Fluorescence/Raman intensity ratio for monitoring the pathologic state of human lens by NAI-TENG YU, BANDO, M, KUCK, J. F. R. JR

“…The authors have put quantitation of human lens fluorescence on a rational basis by using the accompanying Raman signal from lens protein as a normalization…”
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Metabolic production of a blue-green fluorophor in lenses of dark- adapted mice and its increase with age by Yu, NT, Bando, M, Kuck, JF, Jr

“…A blue-green fluorophor (496 nm emission/406.7 nm excitation) occurs in the mouse lens; its increase with age is more pronounced in the nucleus than in the…”
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Localization of UV-induced changes in mouse lens by Yu, N T, Bando, M, Kuck, Jr, J F

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Galactose-induced cataract in rat: Raman detection of sulfhydryl decrease and water increase along an equatorial diameter by Cai, M Z, Kuck, Jr, J F, Yu, N T

“…Raman spectroscopy shows that maturation of galactose cataract greatly increases the water signal (at 3417 cm-1) which is correlated with the inbibition of…”
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The Emory mouse cataract: accumulation of free leucine and incorporation into protein by cataractous and clear lenses by Kuck, Jr, J F, Kuck, K D

“…Leucine metabolism has been studied in the Emory mouse lens to determine if there is a correlation between the rates of leucine accumulation and incorporation…”
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Raman spectroscopic evaluation of aging and long-wave UV exposure in the guinea pig lens: a possible model for human aging by Barron, B C, Yu, N T, Kuck, Jr, J F

“…The laser Raman optical dissection technique makes it possible to study individual points of minute volumes (2 X 10(-3) microliter) in the intact living lens…”
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A Raman study of disulfide and sulfhydryl in the emory mouse cataract by DE NAGEL, D. C, BANDO, M, NAI-TENG YU, KUCK, J. F. R. JR

“…Emory mice (EM) are genetically predisposed to late-onset cataract formation. Our early work has shown UV-exposure slightly enhanced the expected 2 SH---SS…”
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The Emory mouse cataract: the effects on cataractogenesis of alpha-tocopherol, penicillamine, triethylenetetramine, and mercaptopropionylglycine by Kuck, Jr, J F, Kuck, K D

“…The Emory mouse develops a late-onset hereditary cataract bearing some resemblances to human senile cataract. It was used as a model system for testing the…”
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Late onset hereditary cataract of the emory mouse. A model for human senile cataract by Kuck, J F

“…The late onset cataract of the Emory mouse has appealed to many investigators as a useful animal model for human senile cataract. It has been the subject of…”
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Fluorophors and chromophors from rat lens crystallins in UV with hydroxykynurenine by Bando, M, Yu, NT, Kuck, JF

“…Isolated alpha-, beta-, and gamma-crystallins from young rat lenses were incubated in solution for 16 hr with 3-hydroxykynurenine under ultraviolet (366 nm)…”
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