Search Results - "Kucinska, Malgorzata"

More Than Resveratrol: New Insights into Stilbene-Based Compounds by Pecyna, Paulina, Wargula, Joanna, Murias, Marek, Kucinska, Malgorzata

“…The concept of a scaffold concerns many aspects at different steps on the drug development path. In medicinal chemistry, the choice of relevant "drug-likeness"…”
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Between the Devil and the Deep Blue Sea-Resveratrol, Sulfotransferases and Sulfatases-A Long and Turbulent Journey from Intestinal Absorption to Target Cells by Szymkowiak, Izabela, Kucinska, Malgorzata, Murias, Marek

“…For nearly 30 years, resveratrol has attracted the scientific community's interest. This has happened thanks to the so-called French paradox, that is, the…”
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Resveratrol Analogues as Selective Estrogen Signaling Pathway Modulators: Structure–Activity Relationship by Kobylka, Paulina, Kucinska, Malgorzata, Kujawski, Jacek, Lazewski, Dawid, Wierzchowski, Marcin, Murias, Marek

“…Resveratrol is a plant-derived phytoalexin found in grapes, red wine and many other plants used in Asian folk medicine. It is extensively studied for…”
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Unmasking the Deceptive Nature of Cancer Stem Cells: The Role of CD133 in Revealing Their Secrets by Pospieszna, Julia, Dams-Kozlowska, Hanna, Udomsak, Wachirawit, Murias, Marek, Kucinska, Malgorzata

“…Cancer remains a leading cause of death globally, and its complexity poses a significant challenge to effective treatment. Cancer stem cells and their markers…”
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Antioxidant Enzymes in Cancer Cells: Their Role in Photodynamic Therapy Resistance and Potential as Targets for Improved Treatment Outcomes by Udomsak, Wachirawit, Kucinska, Malgorzata, Pospieszna, Julia, Dams-Kozlowska, Hanna, Chatuphonprasert, Waranya, Murias, Marek

“…Photodynamic therapy (PDT) is a selective tumor treatment that consists of a photosensitive compound-a photosensitizer (PS), oxygen, and visible light…”
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The combination therapy using tyrosine kinase receptors inhibitors and repurposed drugs to target patient-derived glioblastoma stem cells by Kucinska, Malgorzata, Pospieszna, Julia, Tang, Jing, Lisiak, Natalia, Toton, Ewa, Rubis, Blazej, Murias, Marek

“…The lesson from many studies investigating the efficacy of targeted therapy in glioblastoma (GBM) showed that a future perspective should be focused on…”
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Enhanced Cytotoxic Activity of PEGylated Curcumin Derivatives: Synthesis, Structure-Activity Evaluation, and Biological Activity by Lazewski, Dawid, Kucinska, Malgorzata, Potapskiy, Edward, Kuzminska, Joanna, Popenda, Lukasz, Tezyk, Artur, Goslinski, Tomasz, Wierzchowski, Marcin, Murias, Marek

“…Curcumin has been modified in various ways to broaden its application in medicine and address its limitations. In this study, we present a series of…”
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Multiharmonic electron paramagnetic resonance imaging as an innovative approach for in vivo studies by Gonet, Michal, Baranowski, Mikolaj, Czechowski, Tomasz, Kucinska, Malgorzata, Plewinski, Adam, Szczepanik, Piotr, Jurga, Stefan, Murias, Marek

“…This work is the first report when multiharmonic analysis (MHA) was applied for electron paramagnetic resonance imaging (EPRI) for in vivo applications…”
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Novel fluorocurcuminoid-BF2 complexes and their unlocked counterparts as potential bladder anticancer agents – synthesis, physicochemical characterization, and in vitro anticancer activity by Kuźmińska, Joanna, Kobyłka, Paulina, Wierzchowski, Marcin, Łażewski, Dawid, Popenda, Łukasz, Szubska, Paulina, Jankowska, Weronika, Jurga, Stefan, Goslinski, Tomasz, Muszalska-Kolos, Izabela, Murias, Marek, Kucińska, Małgorzata, Sobczak, Agnieszka, Jelińska, Anna

“…Low efficiency of anticancer drugs and their toxicity in normal tissues has motivated further study on safe and effective modern anticancer agents. In the…”
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Phthalocyanine Derivatives Possessing 2‑(Morpholin-4-yl)ethoxy Groups As Potential Agents for Photodynamic Therapy by Kucinska, Malgorzata, Skupin-Mrugalska, Paulina, Szczolko, Wojciech, Sobotta, Lukasz, Sciepura, Mateusz, Tykarska, Ewa, Wierzchowski, Marcin, Teubert, Anna, Fedoruk-Wyszomirska, Agnieszka, Wyszko, Eliza, Gdaniec, Maria, Kaczmarek, Mariusz, Goslinski, Tomasz, Mielcarek, Jadwiga, Murias, Marek

“…Three 2-(morpholin-4-yl)ethoxy substituted phthalocyanines were synthesized and characterized. Phthalocyanine derivatives revealed moderate to high quantum…”
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Design, synthesis, and biological evaluation of novel combretastatin A-4 thio derivatives as microtubule targeting agents by Stefański, Tomasz, Mikstacka, Renata, Kurczab, Rafał, Dutkiewicz, Zbigniew, Kucińska, Małgorzata, Murias, Marek, Zielińska-Przyjemska, Małgorzata, Cichocki, Michał, Teubert, Anna, Kaczmarek, Mariusz, Hogendorf, Adam, Sobiak, Stanisław

“…A series of novel combretastatin A-4 (CA-4) thio derivatives containing different molecular cores, namely α-phenylcinnamic acids (core 1), (Z)-stilbenes (core…”
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Cytotoxic activity of physodic acid and acetone extract from Hypogymnia physodes against breast cancer cell lines by Studzińska-Sroka, Elżbieta, Piotrowska, Hanna, Kucińska, Małgorzata, Murias, Marek, Bylka, Wiesława

“…Context: Lichens produce specific secondary metabolites with different biological activity. Objective: This study investigated the cytotoxic effects of…”
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The protective activity of mesothelial cells against peritoneal growth of gastrointestinal tumors: The role of soluble ICAM-1 by Mikuła-Pietrasik, Justyna, Uruski, Paweł, Kucińska, Małgorzata, Tykarski, Andrzej, Książek, Krzysztof

“…•Mesothelial cells inhibit growth of gastrointestinal tumors in mice peritoneum.•Adhesion of gastrointestinal cancer cells to HPMCs is mediated by ICAM-1 and…”
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3′-hydroxy-3,4,5,4′-tetramethoxystilbene, the metabolite of resveratrol analogue DMU-212, inhibits ovarian cancer cell growth in vitro and in a mice xenograft model by Piotrowska-Kempisty, Hanna, Ruciński, Marcin, Borys, Sylwia, Kucińska, Małgorzata, Kaczmarek, Mariusz, Zawierucha, Piotr, Wierzchowski, Marcin, Łażewski, Dawid, Murias, Marek, Jodynis-Liebert, Jadwiga

“…In screening studies, the cytotoxic activity of four metabolites of resveratrol analogue 3,4,5,4′-tetramethoxystilbene (DMU-212) against A-2780 and SKOV-3…”
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Novel Short PEG Chain-Substituted Porphyrins: Synthesis, Photochemistry, and In Vitro Photodynamic Activity against Cancer Cells by Lazewski, Dawid, Kucinska, Malgorzata, Potapskiy, Edward, Kuzminska, Joanna, Tezyk, Artur, Popenda, Lukasz, Jurga, Stefan, Teubert, Anna, Gdaniec, Zofia, Kujawski, Jacek, Grzyb, Katarzyna, Pedzinski, Tomasz, Murias, Marek, Wierzchowski, Marcin

“…This work presents the synthesis and characterization of metal-free, zinc (II), and cobalt (II) porphyrins substituted with short PEG chains. The synthesized…”
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Role of CYP1A1 in the biological activity of methylated resveratrol analogue, 3,4,5,4′-tetramethoxystilbene (DMU-212) in ovarian cancer A-2780 and non-cancerous HOSE cells by Piotrowska-Kempisty, Hanna, Klupczyńska, Agnieszka, Trzybulska, Dorota, Kulcenty, Katarzyna, Sulej-Suchomska, Anna Maria, Kucińska, Małgorzata, Mikstacka, Renata, Wierzchowski, Marcin, Murias, Marek, Baer-Dubowska, Wanda, Kokot, Zenon, Jodynis-Liebert, Jadwiga

“…[Display omitted] •CYP1A1 is the major enzyme of CYP1 family involved in the biotransformation of DMU-212.•The cytotoxic effects of DMU-212 are related to the…”
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Colorectal cancer-promoting activity of the senescent peritoneal mesothelium by Mikuła-Pietrasik, Justyna, Sosińska, Patrycja, Maksin, Konstantin, Kucińska, Mał Gorzata, Piotrowska, Hanna, Murias, Marek, Woźniak, Aldona, Szpurek, Dariusz, Książek, Krzysztof

“…Gastrointestinal cancers metastasize into the peritoneal cavity in a process controlled by peritoneal mesothelial cells (HPMCs). In this paper we examined if…”
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Morpholinated curcuminoids against urinary bladder cancer cells: synthesis and anticancer evaluation by Bakun, Pawel, Kucinska, Malgorzata, Kobyłka, Paulina, Kuźmińska, Joanna, Koczorowski, Tomasz, Mlynarczyk, Dariusz T., Popenda, Lukasz, Górska, Katarzyna, Kasperkowiak, Małgorzata, Murias, Marek, Jelińska, Anna, Goslinski, Tomasz

“…Cancers present a significant medical problem despite the development of medical and pharmaceutical sciences leading to a search for further therapeutic…”
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Liposomal Nanoformulation as a Carrier for Curcumin and pEGCG-Study on Stability and Anticancer Potential by Piwowarczyk, Ludwika, Kucinska, Malgorzata, Tomczak, Szymon, Mlynarczyk, Dariusz T, Piskorz, Jaroslaw, Goslinski, Tomasz, Murias, Marek, Jelinska, Anna

“…Nanoformulations are regarded as a promising tool to enable the efficient delivery of active pharmaceutical ingredients to the target site. One of the…”
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Resveratrol and its synthetic derivatives exert opposite effects on mesothelial cell-dependent angiogenesis via modulating secretion of VEGF and IL-8/CXCL8 by Mikuła-Pietrasik, Justyna, Kuczmarska, Angelika, Kucińska, Małgorzata, Murias, Marek, Wierzchowski, Marcin, Winckiewicz, Marek, Staniszewski, Ryszard, Bręborowicz, Andrzej, Książek, Krzysztof

“…We examined the effect of resveratrol (RVT) and its two derivatives (3,3′,4,4′-tetrahydroxy- trans -stilbene and 3,3′,4,4′,5,5′-hexahydroxy- trans -stilbene)…”
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