Search Results - "Kucik, Dennis F."

Inhibition of Phosphatidylinositol 3-Kinase Enhances Mitogenic Actions of Insulin in Endothelial Cells by Montagnani, Monica, Golovchenko, Inga, Kim, Injune, Koh, Gou Young, Goalstone, Marc L., Mundhekar, Ameya N., Johansen, Mette, Kucik, Dennis F., Quon, Michael J., Draznin, Boris

“…The concept of “selective insulin resistance” has emerged as a unifying hypothesis in attempts to reconcile the influence of insulin resistance with that of…”
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Iron-Ion Radiation Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice by Yu, Tao, Parks, Brian W., Yu, Shaohua, Srivastava, Roshni, Gupta, Kiran, Wu, Xing, Khaled, Saman, Chang, Polly Y., Kabarowski, Janusz H., Kucik, Dennis F.

“…Radiation exposure from a number of terrestrial sources is associated with an increased risk for atherosclerosis. Recently, concern over whether exposure to…”
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Thrombospondin signaling through the calreticulin/LDL receptor-related protein co-complex stimulates random and directed cell migration by Orr, A Wayne, Elzie, Carrie A, Kucik, Dennis F, Murphy-Ullrich, Joanne E

“…The matricellular extracellular matrix protein thrombospondin-1 (TSP1) stimulates focal adhesion disassembly through a sequence (known as the hep I peptide) in…”
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Intracellular heterogeneity in adhesiveness of endothelium affects early steps in leukocyte adhesion by Mundhekar, Ameya N, Bullard, Daniel C, Kucik, Dennis F

“…Endothelial cell junctions are thought to be preferential sites for transmigration. However, the factors that determine the site of transmigration are not well…”
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Ionizing Radiation Increases Adhesiveness of Human Aortic Endothelial Cells via a Chemokine-Dependent Mechanism by Khaled, Saman, Gupta, Kiran B., Kucik, Dennis F.

“…Exposure to radiation from a variety of sources is associated with increased risk of heart disease and stroke. Since radiation also induces inflammation, a…”
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Multiple Lupus‐Associated ITGAM Variants Alter Mac‐1 Functions on Neutrophils by Zhou, Yebin, Wu, Jianming, Kucik, Dennis F., White, Nathan B., Redden, David T., Szalai, Alexander J., Bullard, Daniel C., Edberg, Jeffrey C.

“…Objective Multiple studies have demonstrated that single‐nucleotide polymorphisms (SNPs) in the ITGAM locus (including the nonsynonymous SNPs rs1143679,…”
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Identification and kinetic analysis of the interaction between Nck-2 and DOCK180 by Tu, Yizeng, Kucik, Dennis F, Wu, Chuanyue

“…Nck-2 is a newly identified adapter protein comprising three N-terminal SH3 domains and one C-terminal SH2 domain. We have identified in a yeast two-hybrid…”
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Blood substitutes: evolution and future applications by Scott, Mitchell G, Kucik, Dennis F, Goodnough, Lawrence T, Monk, Terri G

“…The development of oxygen-carrying blood substitutes has progressed significantly in the last decade with phase I and phase II clinical trials of both…”
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SDF-1α (CXCL12) regulation of lateral mobility contributes to activation of LFA-1 adhesion by Wu, Xing, Yu, Tao, Bullard, Daniel C, Kucik, Dennis F

“…Regulation of integrin activity enables leukocytes to circulate freely, avoiding inappropriate adhesion while maintaining the ability to adhere quickly at…”
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Human neutrophil flow chamber adhesion assay by Zhou, Yebin, Kucik, Dennis F, Szalai, Alexander J, Edberg, Jeffrey C

“…Neutrophil firm adhesion to endothelial cells plays a critical role in inflammation in both health and disease. The process of neutrophil firm adhesion…”
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Revealing anti-inflammatory mechanisms of soy isoflavones by flow: modulation of leukocyte-endothelial cell interactions by Chacko, Balu K, Chandler, Robert T, Mundhekar, Ameya, Khoo, Nicholas, Pruitt, Heather M, Kucik, Dennis F, Parks, Dale A, Kevil, Christopher G, Barnes, Stephen, Patel, Rakesh P

“…The antiatherogenic effects of soy isoflavone consumption have been demonstrated in a variety of studies. However, the mechanisms involved remain poorly…”
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Affinity, lateral mobility, and clustering contribute independently to beta 2-integrin-mediated adhesion by Yu, Tao, Wu, Xing, Gupta, Kiran B, Kucik, Dennis F

“…Affinity changes and avidity modulation both contribute to activation of beta(2)-integrin-mediated adhesion, an essential, early step in inflammation. Avidity…”
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The Microtubule Cytoskeleton Participates in Control of β2 Integrin Avidity by Zhou, Ximing, Li, Jianxun, Kucik, Dennis F.

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Early changes in vascular reactivity in response to 56Fe irradiation in ApoE–/– mice by White, C. Roger, Yu, Tao, Gupta, Kiran, Babitz, Stephen K., Black, Leland L., Kabarowski, Janusz H., Kucik, Dennis F.

“…Epidemiological studies have established that radiation from a number of terrestrial sources increases the risk of atherosclerosis. The accelerated heavy ions…”
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Intercellular Adhesion Molecule-1 (ICAM-1) Regulates Endothelial Cell Motility through a Nitric Oxide-dependent Pathway by Kevil, Christopher G, Orr, A Wayne, Langston, Will, Mickett, Kathryn, Murphy-Ullrich, Joanne, Patel, Rakesh P, Kucik, Dennis F, Bullard, Daniel C

“…Coordinated regulation of endothelial cell migration is an integral process during angiogenesis. However, molecular mechanisms regulating endothelial cell…”
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Measurement of adhesion under flow conditions by Kucik, Dennis F

“…This unit describes the analysis of dynamic cell adhesion using a flow chamber assay. The flow chamber enables the researcher to reconstruct cell systems in…”
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Cell-adhesion assays by Kucik, Dennis F, Wu, Chuanyue

“…One of the most important properties of cells that are derived from multicellular organisms is their ability to adhere to extracellular matrix proteins or…”
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Heavy-ion (56Fe) irradiation leads to impaired aortic relaxation prior to atherosclerotic plaque formation in ApoE−/− mice by White, C.R., Yu, T., Gupta, K., Kabarowski, J.H., Kucik, Dennis F.

“…Terrestrial radiation exposure is a well-established risk factor for cardiovascular disease. For example, coronary artery disease and stroke are both…”
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Both Th1 and Th2 Cells Require P-Selectin Glycoprotein Ligand-1 for Optimal Rolling on Inflamed Endothelium by Mangan, Paul R., O'Quinn, Darrell, Harrington, Laurie, Bonder, Claudine S., Kubes, Paul, Kucik, Dennis F., Bullard, Daniel C., Weaver, Casey T.

“…The acquisition of homing receptors that redirect lymphocyte trafficking to nonlymphoid tissues after antigen encounter is a fundamental aspect of effector…”
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Rearrangement of integrins in avidity regulation by leukocytes by Kucik, Dennis F

“…Leukocyte adhesion must be tightly controlled in order for leukocytes to patrol the body as nonadherent cells, yet stop and emigrate from the blood into…”
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