Search Results - "Kucich, U."

Aprotinin inhibits the contact, neutrophil, and platelet activation systems during simulated extracorporeal perfusion by Wachtfogel, Y T, Kucich, U, Hack, C E, Gluszko, P, Niewiarowski, S, Colman, R W, Edmunds, Jr, L H

“…Aprotinin reduces blood loss after cardiac operations and decreases the bleeding time. The mechanism of action of aprotinin that produces these effects is not…”
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MR889, a neutrophil elastase inhibitor, in patients with chronic obstructive pulmonary disease: a double-blind, randomized, placebo-controlled clinical trial by Luisetti, M, Sturani, C, Sella, D, Madonini, E, Galavotti, V, Bruno, G, Peona, V, Kucich, U, Dagnino, G, Rosenbloom, J, Starcher, B, Grassi, C

“…We investigated whether MR889, a synthetic cyclic thiolic elastase inhibitor, administered for a period of 4 weeks to chronic obstructive pulmonary disease…”
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Mast cell enzymes alter the connective tissue phenotype of bladder wall fibroblasts and smooth muscle cells by Howard, P.S, Renfrow, D, Ford, S, Kucich, U, Schechter, N

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Immunolocalization of elastase in human emphysematous lungs by DAMIANO, V. V, TSANG, A, KUCICH, U, ABRAMS, W. R, ROSENBLOOM, J, KIMBEL, P, FALLAHNEJAD, M, WEINBAUM, G

“…The current working hypothesis concerning the pathogenesis of human pulmonary emphysema proposes that neutrophils migrate through the alveolar interstitium and…”
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Selective kallikrein inhibitors alter human neutrophil elastase release during extracorporeal circulation by Wachtfogel, Y T, Hack, C E, Nuijens, J H, Kettner, C, Reilly, T M, Knabb, R M, Bischoff, R, Tschesche, H, Wenzel, H, Kucich, U

“…Cardiopulmonary bypass causes hemorrhagic complications and initiates a biochemical and cellular "whole body inflammatory response." This study investigates…”
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Human neutrophil degranulation during extracorporeal circulation by Wachtfogel, YT, Kucich, U, Greenplate, J, Gluszko, P, Abrams, W, Weinbaum, G, Wenger, RK, Rucinski, B, Niewiarowski, S, Edmunds, LH Jr

“…Cardiopulmonary bypass, especially when prolonged, may result in hemostatic failure and pulmonary dysfunction, which has been attributed to changes in…”
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Human neutrophils contain and bind high molecular weight kininogen by GUSTAFSON, E. J, SCHMAIER, A. H, WACHTFOGEL, Y. T, KAUFMAN, N, KUCICH, U, COLMAN, R. W

“…Because plasma kallikrein activates human neutrophils, and in plasma prekallikrein (PK) circulates complexed with high molecular weight kininogen (HMWK), we…”
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Purified plasma factor XIIa aggregates human neutrophils and causes degranulation by WACHTFOGEL, Y. T, PIXLEY, R. A, KUCICH, U, ABRAMS, W, WEINBAUM, G, SCHAPIRA, M, COLMAN, R. W

“…Plasma kallikrein has been shown to aggregate human neutrophils and release human neutrophil elastase. However, neutrophils resuspended in factor XII-deficient…”
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Effects of simulated extracorporeal circulation on human leukocyte elastase release, superoxide generation, and procoagulant activity by Stahl, R F, Fisher, C A, Kucich, U, Weinbaum, G, Warsaw, D S, Stenach, N, O'Connor, C, Addonizio, V P

“…Activated leukocytes are thought to contribute to respiratory dysfunction, alterations in microvascular permeability, disseminated intravascular coagulation,…”
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Fibronectin degradation products containing the cytoadhesive tetrapeptide stimulate human neutrophil degranulation by WACHTFOGEL, Y. T, ABRAMS, W, KUCICH, U, WEINBAUM, G, SCHAPIRA, M, COLMAN, R. W

“…We investigated whether adhesive glycoproteins, such as fibronectin or fibrinogen, could function to provide a nidus for neutrophil degranulation. Elastase…”
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Ultrastructural quantitation of peroxidase- and elastase-containing granules in human neutrophils by Damiano, VV, Kucich, U, Murer, E, Laudenslager, N, Weinbaum, G

“…Previous ultrastructural studies of human neutrophils showed two distinctive granule types, the azurophil (peroxidase-positive) and the specific…”
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Identification of multiple tropoelastins secreted by bovine cells by Wrenn, D.S., Parks, W.C., Whitehouse, L.A., Crouch, E.C., Kucich, U., Rosenbloom, J., Mecham, R.P.

“…High resolution gradient sodium dodecyl sulfate-polyacrylamide gel electrophoresis, cell-free translation, and elastin-specific antibodies were used to…”
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Transforming Growth Factor-beta Stabilizes Elastin mRNA by a Pathway Requiring Active Smads, Protein Kinase C-delta , and p38 by Kucich, Umberto, Rosenbloom, Joan C, Abrams, William R, Rosenbloom, Joel

“…Transforming growth factors (TGFs)-beta are multipotent in their biologic activity, regulating cell growth and differentiation as well as extracellular matrix…”
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Measurement of elastin-derived peptides by Weinbaum, G, Kucich, U, Kimbel, P, Mette, S, Akers, S, Rosenbloom, J

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Functional changes in bladder tissue from type III collagen-deficient mice by Stevenson, Karen, Kucich, Umberto, Whitbeck, Catherine, Levin, Robert M, Howard, Pamela S

“…Collagen fibers impart tensile strength and transfer tension from bladder smooth muscle cells. We have previously shown that fibrotic bladders are…”
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Purification of elastin antigen(s) from the urine of patients with emphysema by Kucich, U, Hamilton, J, Akers, S, Kimbel, P, Mette, S, Rosenbloom, J, Weinbaum, G

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Transforming growth factor-beta1–induced hypertrophy and matrix expression in human bladder smooth muscle cells by Howard, Pamela S., Kucich, Umberto, Coplen, Douglas E., He, Yuling

“…To determine whether transforming growth factor beta (TGF-beta) could activate hyperplasia, hypertrophy, and altered collagen expression in human detrusor…”
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Effect of cleavage of the heavy chain of human plasma kallikrein on its functional properties by Colman, RW, Wachtfogel, YT, Kucich, U, Weinbaum, G, Hahn, S, Pixley, RA, Scott, CF, de Agostini, A, Burger, D, Schapira, M

“…Human plasma kallikrein consists of an N-terminal heavy chain of molecular weight (mol wt) 52,000, linked by disulfide bonds to two light chain variants (mol…”
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Role of protein kinase C-delta in the regulation of collagen gene expression in scleroderma fibroblasts by Jimenez, S A, Gaidarova, S, Saitta, B, Sandorfi, N, Herrich, D J, Rosenbloom, J C, Kucich, U, Abrams, W R, Rosenbloom, J

“…Working with cultured dermal fibroblasts derived from control individuals and patients with systemic sclerosis (SSc), we have examined the effects of protein…”
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Mast Cell Chymase Modifies Cell-Matrix Interactions and Inhibits Mitogen-Induced Proliferation of Human Airway Smooth Muscle Cells by Lazaar, Aili L, Plotnick, Michael I, Kucich, Umberto, Crichton, Irene, Lotfi, Shidan, Das, Susan K. P, Kane, Sibyl, Rosenbloom, Joel, Panettieri, Reynold A., Jr, Schechter, Norman M, Pure, Ellen

“…The hallmarks of chronic, severe asthma include prominent airway inflammation and airway smooth muscle (ASM) hypertrophy and hyperplasia. One of the factors…”
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