Search Results - "Kuchkovska, Yuliya"

Impact of Fluoroalkyl Substituents on the Physicochemical Properties of Saturated Heterocyclic Amines by Melnykov, Kostiantyn P., Tavlui, Olha, Skreminskiy, Artem, Kuchkovska, Yuliya O., Grygorenko, Oleksandr O.

“…The physicochemical properties (pKa(H), log P, and aqueous solubility) of fluoroalkyl‐substituted heterocyclic amines were profiled to facilitate the amines’…”
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Formyl MIDA Boronate: C1 Building Block Enables Straightforward Access to α‐Functionalized Organoboron Derivatives by Ivon, Yevhen M., Mazurenko, Ivan V., Kuchkovska, Yuliya O., Voitenko, Zoya V., Grygorenko, Oleksandr O.

“…Formyl MIDA boronate has been known to be an elusive type of acylboronate that has not been obtained to date. In this work, an approach to the one‐pot…”
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Aliphatic α‐Boryl‐α‐bromoketones: Synthesis and Reactivity by Ivon, Yevhen M., Kuchkovska, Yuliya O., Voitenko, Zoya V., Grygorenko, Oleksandr O.

“…A protocol for the preparation of α‐boryl‐α‐bromoketones from alkenyl MIDA boronates was developed and applied to functionalized aliphatic derivatives. The…”
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Last of the gem-Difluorocycloalkanes: Synthesis and Characterization of 2,2-Difluorocyclobutyl-Substituted Building Blocks by Chernykh, Anton V, Melnykov, Kostiantyn P, Tolmacheva, Nataliya A, Kondratov, Ivan S, Radchenko, Dmytro S, Daniliuc, Constantin G, Volochnyuk, Dmitriy M, Ryabukhin, Sergey V, Kuchkovska, Yuliya O, Grygorenko, Oleksandr O

“…An efficient approach to synthesis of previously unavailable 2-substituted difluorocyclobutane building blocks was developed and applied on a multigram scale…”
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Fluoroalkyl-Substituted Cyclopropane Derivatives: Synthesis and Physicochemical Properties by Chernykh, Anton V, Olifir, Oleksandr S, Kuchkovska, Yuliya O, Volochnyuk, Dmitriy M, Yarmolchuk, Vladimir S, Grygorenko, Oleksandr O

“…A series of all 12 cis- and trans-cyclopropanecarboxylic acids and cyclopropylamines bearing CH2F, CHF2, and CF3 substituents were synthesized by different…”
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gem‐Difluorocyclopropanation of Alkenyl Trifluoroborates with the CF3SiMe3–NaI System by Hryshchuk, Oleksandr V., Varenyk, Anatolii O., Yurov, Yevhen, Kuchkovska, Yuliya O., Tymtsunik, Andriy V., Grygorenko, Oleksandr O.

“…Difluorocyclopropanation of alkenyl trifluoroborates using TMSCF3–NaI system was reported for the first time. The developed method allowed preparation of…”
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3‑((Hetera)cyclobutyl)azetidines, “Stretched” Analogues of Piperidine, Piperazine, and Morpholine: Advanced Building Blocks for Drug Discovery by Feskov, Illia O, Chernykh, Anton V, Kuchkovska, Yuliya O, Daniliuc, Constantin G, Kondratov, Ivan S, Grygorenko, Oleksandr O

“…Four 3-((hetera)­cyclobutyl)­azetidine-based isosteres of piperidine, piperazine, and morpholine were designed and synthesized on up to gram scale. The key…”
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Regioselective Synthesis of Functionalized 3- or 5‑Fluoroalkyl Isoxazoles and Pyrazoles from Fluoroalkyl Ynones and Binucleophiles by Chalyk, Bohdan A, Khutorianskyi, Andrii, Lysenko, Andrii, Fil, Yulia, Kuchkovska, Yuliya O, Gavrilenko, Konstantin S, Bakanovych, Iulia, Moroz, Yurii S, Gorlova, Alina O, Grygorenko, Oleksandr O

“…A facile synthetic route toward either 3- or 5-fluoroalkyl-substituted isoxazoles or pyrazoles containing an additional functionalization site was developed…”
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Last of the gem‐Difluorocycloalkanes 2: Synthesis of Fluorinated Cycloheptane Building Blocks by Herasymchuk, Maksym, Melnykov, Kostiantyn P., Yarmoliuk, Dmytro V., Serhiichuk, Dmytro, Rotar, Valeriia, Pukhovoi, Timur, Kuchkovska, Yuliya O., Holovach, Sergey, Volochnyuk, Dmitriy M., Ryabukhin, Sergey V., Grygorenko, Oleksandr O.

“…The gem‐difluorocycloalkane family was extended to all possible regioisomers of the gem‐difluorocycloheptane, monofunctionalized by carboxilic‐, amino‐ or…”
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Formyl MIDA Boronate: C 1 Building Block Enables Straightforward Access to α-Functionalized Organoboron Derivatives by Ivon, Yevhen M, Mazurenko, Ivan V, Kuchkovska, Yuliya O, Voitenko, Zoya V, Grygorenko, Oleksandr O

“…Formyl MIDA boronate has been known to be an elusive type of acylboronate that has not been obtained to date. In this work, an approach to the one-pot…”
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Synthesis of Functionalized Bridged Bicyclic Sulfonamides with a Bridgehead Nitrogen Atom by Blahun, Oleksandr P., Melnychenko, Heorhii, Kuchkovska, Yuliya O., Zhersh, Serhii, Tolmachev, Andrey A., Grygorenko, Oleksandr O.

“…Two approaches to the synthesis of functionalized bridged bicyclic sulfonamides with a bridgehead nitrogen atom were developed. The target compounds were…”
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Impact of β-perfluoroalkyl substitution of proline on the proteolytic stability of its peptide derivatives by Chernykh, Anton V, Aloshyn, Danylo, Kuchkovska, Yuliya O, Daniliuc, Constantin G, Tolmachova, Nataliya A, Kondratov, Ivan S, Zozulya, Sergey, Grygorenko, Oleksandr O, Haufe, Günter

“…A series of all stereoisomers of β-CF or β-C F substituted prolines and their dipeptide derivatives were synthesized. Mouse plasma stability assay was carried…”
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Multigram Synthesis of Functionalized Spirocyclic Diazirines by Martyloga, Oleksandr V., Myronenko, Artamon, Tkachenko, Anton M., Matvienko, Vitalii O., Kuchkovska, Yuliya O., Grygorenko, Oleksandr O.

“…An approach to the synthesis of spirocyclic diazirines from cyclic ketones was examined on a series of carbo‐ and heterocyclic substrates containing the amine…”
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One-Pot Parallel Synthesis of 5‑(Dialkylamino)tetrazoles by Savych, Olena, Kuchkovska, Yuliya O, Bogolyubsky, Andrey V, Konovets, Anzhelika I, Gubina, Kateryna E, Pipko, Sergey E, Zhemera, Anton V, Grishchenko, Alexander V, Khomenko, Dmytro N, Brovarets, Volodymyr S, Doroschuk, Roman, Moroz, Yurii S, Grygorenko, Oleksandr O

“…Two protocols for the combinatorial synthesis of 5-(dialkylamino)­tetrazoles were developed. The best success rate (67%) was shown by the method that used…”
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Formyl MIDA Boronate: C1 Building Block Enables Straightforward Access to α‐Functionalized Organoboron Derivatives by Ivon, Yevhen M., Mazurenko, Ivan V., Kuchkovska, Yuliya O., Voitenko, Zoya V., Grygorenko, Oleksandr O.

“…Formyl MIDA boronate has been known to be an elusive type of acylboronate that has not been obtained to date. In this work, an approach to the one‐pot…”
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Front Cover: Aliphatic α‐Boryl‐α‐bromoketones: Synthesis and Reactivity (Eur. J. Org. Chem. 23/2020) by Ivon, Yevhen M., Kuchkovska, Yuliya O., Voitenko, Zoya V., Grygorenko, Oleksandr O.

“…The Front Cover shows aliphatic α‐boryl‐α‐bromoketones – versatile trifunctional templates for synthesis of organoboronates. The title compounds are depicted…”
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Synthesis of azabicyclo[n.1.0]alkane-derived bifunctional building blocks via the Corey–Chaykovsky cyclopropanation by Yarmoliuk, Dmytro V., Serhiichuk, Dmytro, Smyrnov, Vladyslav, Tymtsunik, Andriy V., Hryshchuk, Oleksandr V., Kuchkovska, Yuliya, Grygorenko, Oleksandr O.

“…[Display omitted] •Synthesis of azabicyclo[5.1.0]octane(methanoazepane)-derived amino acids and diamines is reported.•The Corey–Chaikovsky cyclopropanation is…”
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gem ‐Difluorocyclopropanation of Alkenyl Trifluoroborates with the CF 3 SiMe 3 –NaI System by Hryshchuk, Oleksandr V., Varenyk, Anatolii O., Yurov, Yevhen, Kuchkovska, Yuliya O., Tymtsunik, Andriy V., Grygorenko, Oleksandr O.

“…Difluorocyclopropanation of alkenyl trifluoroborates using TMSCF 3 –NaI system was reported for the first time. The developed method allowed preparation of…”
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Synthesis of 3‐Azabicyclo[3.2.0]heptane‐Derived Building Blocks via [3+2] Cycloaddition by Homon, Anton A., Hryshchuk, Oleksandr V., Trofymchuk, Serhii, Michurin, Oleg, Kuchkovska, Yuliya, Radchenko, Dmytro S., Grygorenko, Oleksandr O.

“…An efficient approach to synthesis of various substituted 3‐azabicyclo[3.2.0]heptane‐derived building blocks based on [3+2] cycloaddition of…”
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The Boron‐Wittig Olefination of Aldehydes and Ketones with Bis[(pinacolato)boryl]methane: an Extended Reaction Scope by Kovalenko, Maksym, Yarmoliuk, Dmytro V., Serhiichuk, Dmytro, Chernenko, Daria, Smyrnov, Vladyslav, Breslavskyi, Artur, Hryshchuk, Oleksandr V., Kleban, Ihor, Rassukana, Yuliya, Tymtsunik, Andriy V., Tolmachev, Andrey A., Kuchkovska, Yuliya O., Grygorenko, Oleksandr O.

“…Preparation of 2,2‐disubstituted and 2‐monosubstituted alkenylboronic acid esters from aliphatic and aromatic ketones and aldehydes by the boron‐Wittig…”
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