Search Results - "Kucherlapati, Melanie"

Examining transcriptional changes to DNA replication and repair factors over uveal melanoma subtypes by Kucherlapati, Melanie

“…Uncontrolled replication is a process common to all cancers facilitated by the summation of changes accumulated as tumors progress. The aim of this study was…”
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Msh2 acts in medium-spiny striatal neurons as an enhancer of CAG instability and mutant huntingtin phenotypes in Huntington's disease knock-in mice by Kovalenko, Marina, Dragileva, Ella, St Claire, Jason, Gillis, Tammy, Guide, Jolene R, New, Jaclyn, Dong, Hualing, Kucherlapati, Raju, Kucherlapati, Melanie H, Ehrlich, Michelle E, Lee, Jong-Min, Wheeler, Vanessa C

“…The CAG trinucleotide repeat mutation in the Huntington's disease gene (HTT) exhibits age-dependent tissue-specific expansion that correlates with disease…”
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Global impact of somatic structural variation on the DNA methylome of human cancers by Zhang, Yiqun, Yang, Lixing, Kucherlapati, Melanie, Hadjipanayis, Angela, Pantazi, Angeliki, Bristow, Christopher A, Lee, Eunjung Alice, Mahadeshwar, Harshad S, Tang, Jiabin, Zhang, Jianhua, Seth, Sahil, Lee, Semin, Ren, Xiaojia, Song, Xingzhi, Sun, Huandong, Seidman, Jonathan, Luquette, Lovelace J, Xi, Ruibin, Chin, Lynda, Protopopov, Alexei, Park, Peter J, Kucherlapati, Raju, Creighton, Chad J

“…Genomic rearrangements exert a heavy influence on the molecular landscape of cancer. New analytical approaches integrating somatic structural variants (SSVs)…”
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An Msh2 Conditional Knockout Mouse for Studying Intestinal Cancer and Testing Anticancer Agents by Kucherlapati, Melanie H, Lee, Kyeryoung, Nguyen, Andrew A, Clark, Alan B, Hou, Harry, Rosulek, Andrew, Li, Hua, Yang, Kan, Fan, Kunhua, Lipkin, Martin, Bronson, Roderick T, Jelicks, Linda, Kunkel, Thomas A, Kucherlapati, Raju, Edelmann, Winfried

“…Background & Aims Mutations in the DNA mismatch repair (MMR) gene MSH2 cause Lynch syndromes I and II and sporadic colorectal cancers. Msh2 null mice…”
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A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases by Zhang, Yiqun, Yang, Lixing, Kucherlapati, Melanie, Chen, Fengju, Hadjipanayis, Angela, Pantazi, Angeliki, Bristow, Christopher A., Lee, Eunjung A., Mahadeshwar, Harshad S., Tang, Jiabin, Zhang, Jianhua, Seth, Sahil, Lee, Semin, Ren, Xiaojia, Song, Xingzhi, Sun, Huandong, Seidman, Jonathan, Luquette, Lovelace J., Xi, Ruibin, Chin, Lynda, Protopopov, Alexei, Li, Wei, Park, Peter J., Kucherlapati, Raju, Creighton, Chad J.

“…A systematic cataloging of genes affected by genomic rearrangement, using multiple patient cohorts and cancer types, can provide insight into cancer-relevant…”
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Mouse models in colon cancer, inferences, and implications by Kucherlapati, Melanie Haas

“…Mouse models of colorectal cancer (CRC) have been crucial in the identification of the role of genes responsible for the full range of pathology of the human…”
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A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease by McDonald, David A, Shenkar, Robert, Shi, Changbin, Stockton, Rebecca A, Akers, Amy L, Kucherlapati, Melanie H, Kucherlapati, Raju, Brainer, James, Ginsberg, Mark H, Awad, Issam A, Marchuk, Douglas A

“…Cerebral cavernous malformations (CCMs) are vascular lesions of the central nervous system appearing as multicavernous, blood-filled capillaries, leading to…”
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Mesalazine and thymoquinone attenuate intestinal tumour development in Msh2(loxP/loxP) Villin-Cre mice by Kortüm, Benedikt, Campregher, Christoph, Lang, Michaela, Khare, Vineeta, Pinter, Matthias, Evstatiev, Rayko, Schmid, Gerald, Mittlböck, Martina, Scharl, Theresa, Kucherlapati, Melanie H, Edelmann, Winfried, Gasche, Christoph

“…Lynch syndrome is caused by germline mutations in DNA mismatch repair genes leading to microsatellite instability (MSI) and colorectal cancer. Mesalazine,…”
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Genotype directed therapy in murine mismatch repair deficient tumors by Kucherlapati, Melanie H, Esfahani, Shadi, Habibollahi, Peiman, Wang, Junning, Still, Eric R, Bronson, Roderick T, Mahmood, Umar, Kucherlapati, Raju S

“…The PI3K/AKT/mTOR pathway has frequently been found activated in human tumors. We show that in addition to Wnt signaling dysfunction, the PI3K/AKT/mTOR pathway…”
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An EGFR targeted PET imaging probe for the detection of colonic adenocarcinomas in the setting of colitis by Turker, N Selcan, Heidari, Pedram, Kucherlapati, Raju, Kucherlapati, Melanie, Mahmood, Umar

“…Colorectal cancer is a serious complication associated with inflammatory bowel disease, often indistinguishable by screening with conventional FDG PET probes…”
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Adenomatous polyposis coli (APC) is required for normal development of skin and thymus by Kuraguchi, Mari, Wang, Xiu-Ping, Bronson, Roderick T, Rothenberg, Rebecca, Ohene-Baah, Nana Yaw, Lund, Jennifer J, Kucherlapati, Melanie, Maas, Richard L, Kucherlapati, Raju

“…The tumor suppressor gene Apc (adenomatous polyposis coli) is a member of the Wnt signaling pathway that is involved in development and tumorigenesis…”
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A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains by Mignot, Emmanuel, Peyron, Christelle, Faraco, Juliette, Rogers, William, Ripley, Beth, Overeem, Sebastiaan, Charnay, Yves, Nevsimalova, Sona, Aldrich, Michael, Reynolds, David, Albin, Roger, Li, Robin, Hungs, Marcel, Pedrazzoli, Mario, Padigaru, Muralidhara, Kucherlapati, Melanie, Fan, Jun, Maki, Richard, Lammers, Gert Jan, Bouras, Constantin, Kucherlapati, Raju, Nishino, Seiji

“…We explored the role of hypocretins in human narcolepsy through histopathology of six narcolepsy brains and mutation screening of Hcrt, Hcrtr1 and Hcrtr2 in 74…”
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Optical imaging with a novel cathepsin-activatable probe for enhanced detection of colorectal cancer by Esfahani, Shadi A, Heidari, Pedram, Kucherlapati, Melanie H, Ferrer, Jorge M, Kucherlapati, Raju S, Mahmood, Umar

“…We evaluated a cysteine cathepsin-activatable optical imaging probe (LUM015) with improved kinetics relative to larger macromolecules for detection and…”
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MAPRE1 as a plasma biomarker for early-stage colorectal cancer and adenomas by Taguchi, Ayumu, Rho, Jung-Hyun, Yan, Qingxiang, Zhang, Yuzheng, Zhao, Yang, Xu, Hanwen, Tripathi, Satyendra Chandra, Wang, Hong, Brenner, Dean E, Kucherlapati, Melanie, Kucherlapati, Raju, Boutin, Adam T, Wang, Y Alan, DePinho, Ronald A, Feng, Ziding, Lampe, Paul D, Hanash, Samir M

“…Blood-based biomarkers for early detection of colorectal cancer could complement current approaches to colorectal cancer screening. We previously identified…”
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Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model by McIlhatton, Michael A, Tyler, Jessica, Kerepesi, Laura A, Bocker-Edmonston, Tina, Kucherlapati, Melanie H, Edelmann, Winfried, Kucherlapati, Raju, Kopelovich, Levy, Fishel, Richard

“…Nonsteroidal anti-inflammatory drugs (NSAID) appear to be effective cancer chemopreventives. Previous cellular studies showed that aspirin (acetylsalicylic…”
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80 Mesalazine Decreases Microsatellite Instability and Tumor Development in the Villin-Cre Msh2loxp/Loxp Mouse Model of Lynch Syndrome by Campregher, Christoph, Kortüm, Benedikt, Pinter, Matthias, Lang, Michaela, Evstatiev, Rayko, Khare, Vineeta, Kucherlapati, Melanie H, Edelmann, Winfried, Gasche, Christoph

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Haploinsufficiency of Flap Endonuclease (Fen1) Leads to Rapid Tumor Progression by Kucherlapati, Melanie, Yang, Kan, Kuraguchi, Mari, Zhao, Jie, Lia, Maria, Heyer, Joerg, Kane, Michael F., Fan, Kunhua, Russell, Robert, Anthony M. C. Brown, Kneitz, Burkhard, Edelmann, Winfried, Kolodner, Richard D., Lipkin, Martin, Kucherlapati, Raju

“…Flap endonuclease (Fen1) is required for DNA replication and repair, and defects in the gene encoding Fen1 cause increased accumulation of mutations and genome…”
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A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease by MCDONALD, David A, SHENKAR, Robert, MARCHUK, Douglas A, SHI, Changbin, STOCKTON, Rebecca A, AKERS, Amy L, KUCHERLAPATI, Melanie H, KUCHERLAPATI, Raju, BRAINER, James, GINSBERG, Mark H, AWAD, Issam A

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Co-expression patterns explain how a basic transcriptional role for MYC modulates Wnt and MAPK pathways in colon and lung adenocarcinomas by Kucherlapati, Melanie Haas

“…A subset of proliferation genes that are associated with origin licensing, firing, and DNA synthesis has been compared to known drivers of colon (COAD) and…”
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Inactivation of conditional Rb by Villin-cre leads to aggressive tumors outside the gastrointestinal tract by KUCHERLAPATI, Melanie H, NGUYEN, Andrew A, BRONSON, Roderick T, KUCHERLAPATI, Raju S

“…We have crossed mice carrying the conditional Rb(tm2Brn) allele with a constitutive Villin-Cre transgenic mouse. The Villin promoter in these animals is highly…”
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