Search Results - "Kucher, Olexandr V."

Synthesis of 6‐Azaspiro[4.3]alkanes: Innovative Scaffolds for Drug Discovery by Chalyk, Bohdan A., Isakov, Andrei A., Butko, Maryna V., Hrebeniuk, Kateryna V., Savych, Olena V., Kucher, Olexandr V., Gavrilenko, Konstantin S., Druzhenko, Tetiana V., Yarmolchuk, Vladimir S., Zozulya, Sergey, Mykhailiuk, Pavel K.

“…New scaffolds for drug discovery, 6‐azaspiro[4.3]alkanes, have been synthesized in two steps from four‐membered‐ring ketones: cyclobutanone, thienone,…”
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One‐Pot Synthesis of 6‐Aminopyrido[2,3‐d]pyrimidin‐7‐ones by Zinchenko, Anna M., Muzychka, Lyubov V., Kucher, Olexandr V., Sadkova, Iryna V., Mykhailiuk, Pavel K., Smolii, Oleg B.

“…One‐pot synthesis of 6‐aminopyrido[2,3‐d]pyrimidin‐7‐ones from 4‐aminopyrimidine‐5‐carbaldehydes and the in situ N‐protected methyl glycinate is developed. The…”
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Synthesis and reactions of novel imidazo[4,5-b]pyridine building blocks by Dubina, Tetiana F., Kosarevych, Anton V., Kucher, Olexandr V., Sosunovych, Bohdan S., Smolii, Oleg B., Vashchenko, Bohdan V., Grygorenko, Oleksandr O.

“…The synthesis of a novel imidazo[4,5- b ]pyridine and its partially saturated derivative relied on Michael addition of 1-methyl-1 H -imidazol-4-amine to…”
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Front Cover: Synthesis of 6‐Azaspiro[4.3]alkanes: Innovative Scaffolds for Drug Discovery (Eur. J. Org. Chem. 31/2017) by Chalyk, Bohdan A., Isakov, Andrei A., Butko, Maryna V., Hrebeniuk, Kateryna V., Savych, Olena V., Kucher, Olexandr V., Gavrilenko, Konstantin S., Druzhenko, Tetiana V., Yarmolchuk, Vladimir S., Zozulya, Sergey, Mykhailiuk, Pavel K.

“…The cover picture shows novel scaffolds for drug discovery, 6 azaspiro[4.3]alkanes, which have been synthesized by Enamine chemists (Ukraine, Kyiv). The…”
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Enzyme-Catalyzed Kinetic Resolution of 2,2,2-Trifluoro-1-(heteroaryl)ethanols: Experimental and Docking Studies by Kucher, Olexandr V., Kolodiazhnaya, Anastasiya O., Smolii, Oleg B., Prisuazhnyk, Dmytro V., Tolmacheva, Katerina A., Zaporozhets, Olga A., Moroz, Yurii S., Mykhailiuk, Pavel K., Tolmachev, Andrey A.

“…A convenient approach towards enantiopure (R) and (S) isomers of 2,2,2‐trifluoro‐1‐(heteroaryl)ethanols was developed. The enzyme‐catalyzed kinetic resolution…”
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Crystal structure of ( S )-1-(1,3-benzothiazol-2-yl)-2,2,2-trifluoroethanol by Shishkina, Svitlana V., Kucher, Olexandr V., Kolodiazhnaya, Anastasiya O., Smolii, Oleg B., Tolmachev, Andrey A.

“…In the title compound, C 9 H 6 F 3 NOS, the 1,3-benzothiazole ring system is essentially planar, with an r.m.s. deviation of 0.006 Å. In the crystal, molecules…”
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Synthesis and enzymatic resolution of novel analogs of alicyclic and heterocyclic mandelic acid derivatives by Sosunovych, Bohdan S., Timokhin, Oleksii S., Kucher, Olexandr V., Demianyk, Nadiia Y., Hys, Denys V., Zvarych, Yelyzaveta A., Smolii, Oleg B., Vashchenko, Bohdan V., Grygorenko, Oleksandr O.

“…Synthesis and enzymatic resolution of a new class of alicyclic and heterocyclic mandelic acid derivatives was described. The method relied on the preparation…”
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Synthesis of novel 1,2-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one derivatives by Yaremchuk, Iryna O., Muzychka, Lyubov V., Smolii, Oleg B., Kucher, Olexandr V., Shishkina, Svitlana V.

“…[Display omitted] •Wide range of novel 1,2-dihydropyrrolo[1,2-a]pyrazin-1(2H)-ones was synthesized.•The mechanism of oxazine to pyrazine transformation was…”
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Lipase kinetic enantiomeric resolution of 1-heteroarylethanols by Kucher, Olexandr V., Kolodyazhnaya, Anastasiya O., Smolii, Oleg B., Nazarenko, Nadiya K., Kubyshkin, Vladimir, Mykhailiuk, Pavel K., Tolmachev, Andrey A.

“…[Display omitted] The use of lipases offers a simple and straightforward method toward various chiral secondary alcohols. Here we examined the lipase…”
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Crystal structure of (S)-1-(1,3-benzo-thia-zol-2-yl)-2,2,2-tri-fluoro-ethanol by Shishkina, Svitlana V, Kucher, Olexandr V, Kolodiazhnaya, Anastasiya O, Smolii, Oleg B, Tolmachev, Andrey A

“…In the title compound, C9H6F3NOS, the 1,3-benzo-thia-zole ring system is essentially planar, with an r.m.s. deviation of 0.006 Å. In the crystal, mol-ecules…”
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Enzymatic resolution of chroman-4-ol and its core analogues with Burkholderia cepacia lipase by Kucher, Olexandr V., Kolodyazhnaya, Anastasiya O., Smolii, Oleg B., Boiko, Alexandr I., Kubyshkin, Vladimir S., Mykhailiuk, Pavel K., Tolmachev, Andrey A.

“…A convenient protocol for lipase resolution of chroman-4-ol and its analogues (six- and seven-membered rings with O, S, SO2) has been elaborated. The structure…”
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