Search Results - "Kucera, David J"

Real-Time Monitoring of Solid–Liquid Slurries: Optimized Synthesis of Tetrabenazine by Sato, Yusuke, Liu, Junliang, Kukor, Andrew J, Culhane, Jeffrey C, Tucker, John L, Kucera, David J, Cochran, Brian M, Hein, Jason E

“…Solid–liquid slurries are vital and increasingly prevalent in the pharmaceutical and chemical industries. Despite the importance of these heterogeneous…”
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Fluorination-Free Synthesis of a 4,4-Difluoro-3,3-Dimethylproline Derivative by Chen, Lijian, Kim, Young Mi, Kucera, David J, Harrison, Katheryn E, Bahmanyar, Sogole, Scott, Jill M, Yazbeck, Daniel

“…A Claisen rearrangement/iodolactamization sequence starting from commercially available trifluoroacetaldehyde methyl hemiacetal, followed by a classical…”
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Process Research and Development and Scale-up of a 4,4-Difluoro-3,3-dimethylproline Derivative by Rossi, Francesco, Corcella, Francesco, Caldarelli, Francesco Saverio, Heidempergher, Franco, Marchionni, Chiara, Auguadro, Miriam, Cattaneo, Marco, Ceriani, Lucio, Visentin, Giuseppina, Ventrella, Giambattista, Pinciroli, Vittorio, Ramella, Giuliano, Candiani, Ilaria, Bedeschi, Angelo, Tomasi, Attilio, Kline, Billie J, Martinez, Carlos A, Yazbeck, Daniel, Kucera, David J

“…The multikilogram production of the proline derivative 1, a key intermediate of a HIV protease inhibitor, required the design of a synthetic route able to be…”
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Efficient Enzymatic Process for the Production of (2S)-4,4-Difluoro-3,3-dimethyl-N-Boc-proline, a Key Intermediate in the Synthesis of HIV Protease Inhibitors by Hu, Shanghui, Martinez, Carlos A, Kline, Billie, Yazbeck, Daniel, Tao, Junhua, Kucera, David J

“…(2S)-4,4-Difluoro-3,3-dimethyl-N-Boc-proline (3) is a key intermediate for the synthesis of HIV protease inhibitors. Here, several approaches for the…”
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A novel nitric oxide releasing prostaglandin analog, NCX 125, reduces intraocular pressure in rabbit, dog, and primate models of glaucoma by Borghi, Valentina, Bastia, Elena, Guzzetta, Massimiliano, Chiroli, Valerio, Toris, Carol B, Batugo, Minerva R, Carreiro, Samantha T, Chong, Wesley K M, Gale, David C, Kucera, David J, Jia, Liu, Prasanna, Ganesh, Ongini, Ennio, Krauss, Achim H P, Impagnatiello, Francesco

“…Nitric oxide (NO) is involved in a variety of physiological processes including ocular aqueous humor dynamics by targeting mechanisms that are complementary to…”
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Total synthesis of (.+-.)-scopadulcic acid A. An illustration of the utility of palladium catalyzed polyene cyclizations by Kucera, David J, O'Connor, Stephen J, Overman, Larry E

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Palladium-catalyzed polyene cyclizations of trienyl triflates by Carpenter, Nancy E, Kucera, David J, Overman, Larry E

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Synthesis of [14C]-radiolabelled entecavir by Ogan, Marc D., Kucera, David J., Pendri, Yadagiri R., Kent Rinehart, J.

“…Radiolabelled [14C]entecavir, (1), was prepared in 12 steps from (1S,2R,3S,5R)‐3‐(benzyloxy)‐2‐(benzyloxymethyl)‐6‐oxa‐bicyclo[3.1.0]hexane 2. The chemical…”
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Efficiency and Sustainability through Development of a Next-Generation, Commercial Synthesis of Valbenazine Ditosylate by Tucker, John L., Kucera, David J., Hettinger, Don, Branum, Shawn, Cochran, Brian, Culhane, Jeff, Zhao, Lucy, Palmer, Andrew Benjamin, Leeman, Kyle, Yu, Stanley, Martin, Bénédicte, André, Nicolas, Perron, Julien, Comas, Horacio, Zhao, Yuxin

“…The synthetic process used to manufacture valbenazine ditosylate (API of INGREZZA) has proven to be highly selective and robust, but opportunities remain for…”
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Preparation of seven-membered ring cyclic ethers and 3-alkylidenetetrahydropyrans from the cyclization of oxonium cations derived from unsubstituted and silicon-containing 4-alken-1-ols by Castaneda, Armando, Kucera, David J, Overman, Larry E

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Palladium-catalyzed, polyene cyclizations by Overman, L. E., Abelman, M. M., Kucera, D. J., Tran, V. D., Ricca, D. J.

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