Search Results - "Kucab, Jill E."

A Compendium of Mutational Signatures of Environmental Agents by Kucab, Jill E., Zou, Xueqing, Morganella, Sandro, Joel, Madeleine, Nanda, A. Scott, Nagy, Eszter, Gomez, Celine, Degasperi, Andrea, Harris, Rebecca, Jackson, Stephen P., Arlt, Volker M., Phillips, David H., Nik-Zainal, Serena

“…Whole-genome-sequencing (WGS) of human tumors has revealed distinct mutation patterns that hint at the causative origins of cancer. We examined mutational…”
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Metabolic Activation of Benzo[ a ]pyrene by Human Tissue Organoid Cultures by Caipa Garcia, Angela L, Kucab, Jill E, Al-Serori, Halh, Beck, Rebekah S S, Fischer, Franziska, Hufnagel, Matthias, Hartwig, Andrea, Floeder, Andrew, Balbo, Silvia, Francies, Hayley, Garnett, Mathew, Huch, Meritxell, Drost, Jarno, Zilbauer, Matthias, Arlt, Volker M, Phillips, David H

“…Organoids are 3D cultures that to some extent reproduce the structure, composition and function of the mammalian tissues from which they derive, thereby…”
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Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival by TROUSSARD, Armelle A, MCDONALD, Paul C, DEDHAR, Shoukat, WEDERELL, Elizabeth D, MAWJI, Nasrin M, FILIPENKO, Nolan R, GELMON, Karen A, KUCAB, Jill E, DUNN, Sandra E, EMERMAN, Joanne T, BALLY, Marcel B

“…The emerging paradigm of "oncogene addiction" has been called an Achilles' heel of cancer that can be exploited therapeutically. Here, we show that…”
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The genome as a record of environmental exposure by Nik-Zainal, Serena, Kucab, Jill E, Morganella, Sandro, Glodzik, Dominik, Alexandrov, Ludmil B, Arlt, Volker M, Weninger, Annette, Hollstein, Monica, Stratton, Michael R, Phillips, David H

“…Whole genome sequencing of human tumours has revealed distinct patterns of mutation that hint at the causative origins of cancer. Experimental investigations…”
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Cell cycle alterations induced by urban PM2.5 in bronchial epithelial cells: characterization of the process and possible mechanisms involved by Longhin, Eleonora, Holme, Jørn A, Gutzkow, Kristine B, Arlt, Volker M, Kucab, Jill E, Camatini, Marina, Gualtieri, Maurizio

“…This study explores and characterizes cell cycle alterations induced by urban PM2.5 in the human epithelial cell line BEAS-2B, and elucidates possible…”
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Nutlin‐3a selects for cells harbouring TP53 mutations by Kucab, Jill E., Hollstein, Monica, Arlt, Volker M., Phillips, David H.

“…TP53 mutations occur in half of all human tumours. Mutagen‐induced or spontaneous TP53 mutagenesis can be studied in vitro using the human TP53 knock‐in…”
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Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism by Wohak, Laura E., Krais, Annette M., Kucab, Jill E., Stertmann, Julia, Øvrebø, Steinar, Seidel, Albrecht, Phillips, David H., Arlt, Volker M.

“…The tumour suppressor gene TP53 is mutated in more than 50 % of human tumours, making it one of the most important cancer genes. We have investigated the role…”
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Tissue Organoid Cultures Metabolize Dietary Carcinogens Proficiently and Are Effective Models for DNA Adduct Formation by Caipa Garcia, Angela L., Kucab, Jill E., Al-Serori, Halh, Beck, Rebekah S. S., Bellamri, Madjda, Turesky, Robert J., Groopman, John D., Francies, Hayley E., Garnett, Mathew J., Huch, Meritxell, Drost, Jarno, Zilbauer, Matthias, Arlt, Volker M., Phillips, David H.

“…Human tissue three-dimensional (3D) organoid cultures have the potential to reproduce in vitro the physiological properties and cellular architecture of the…”
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Mutagenicity of acrylamide and glycidamide in human TP53 knock-in (Hupki) mouse embryo fibroblasts by Hölzl-Armstrong, Lisa, Kucab, Jill E., Moody, Sarah, Zwart, Edwin P., Loutkotová, Lucie, Duffy, Veronica, Luijten, Mirjam, Gamboa da Costa, Gonçalo, Stratton, Michael R., Phillips, David H., Arlt, Volker M.

“…Acrylamide is a suspected human carcinogen formed during high-temperature cooking of starch-rich foods. It is metabolised by cytochrome P450 2E1 to its…”
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Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model by Kucab, Jill E, Phillips, David H, Arlt, Volker M

“…TP53 is one of the most commonly mutated genes in human tumours. Variations in the types and frequencies of mutations at different tumour sites suggest that…”
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Mutagenicity of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N–OH-PhIP) in human TP53 knock-in (Hupki) mouse embryo fibroblasts by Hölzl-Armstrong, Lisa, Moody, Sarah, Kucab, Jill E., Zwart, Edwin P., Bellamri, Medjda, Luijten, Mirjam, Turesky, Robert J., Stratton, Michael R., Arlt, Volker M., Phillips, David H.

“…2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a possible human carcinogen formed in cooked fish and meat. PhIP is bioactivated by cytochrome P450…”
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Mutagenicity of N‐hydroxy‐4‐aminobiphenyl in human TP53 knock‐in (Hupki) mouse embryo fibroblasts by Hölzl‐Armstrong, Lisa, Kucab, Jill E., Zwart, Edwin P., Luijten, Mirjam, Phillips, David H., Arlt, Volker M.

“…TP53 harbors somatic mutations in more than half of human tumors with some showing characteristic mutation spectra that have been linked to environmental…”
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Evidence of exposure to aristolochic acid in patients with urothelial cancer from a Balkan endemic nephropathy region of Romania by Schmeiser, Heinz H., Kucab, Jill E., Arlt, Volker M., Phillips, David H., Hollstein, Monica, Gluhovschi, Gheorghe, Gluhovschi, Cristina, Modilca, Mirela, Daminescu, Liviu, Petrica, Ligia, Velciov, Silvia

“…Recently, chronic Aristolochia poisoning was found responsible for the aetiology of Balkan endemic nephropathy (BEN) in Croatia, Serbia, and Bosnia, and diet…”
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TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts by Kucab, Jill E., Zwart, Edwin P., van Steeg, Harry, Luijten, Mirjam, Schmeiser, Heinz H., Phillips, David H., Arlt, Volker M.

“…•We examine TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone (3-NBA).•We utilize Hupki (Human TP53 knock-in) fibroblasts (HUFs) wild-type and null for…”
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TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts by Kucab, Jill E, van Steeg, Harry, Luijten, Mirjam, Schmeiser, Heinz H, White, Paul A, Phillips, David H, Arlt, Volker M

“…Somatic mutations in the tumour suppressor gene TP53 occur in more than 50% of human tumours; in some instances exposure to environmental carcinogens can be…”
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Comparison of the metabolic activation of environmental carcinogens in mouse embryonic stem cells and mouse embryonic fibroblasts by Krais, Annette M., Mühlbauer, Karl-Rudolf, Kucab, Jill E., Chinbuah, Helena, Cornelius, Michael G., Wei, Quan-Xiang, Hollstein, Monica, Phillips, David H., Arlt, Volker M., Schmeiser, Heinz H.

“…•ES cells and MEF have the metabolic competence to activate environmental carcinogens.•Carcinogen-induced genotoxicity in MEFs is higher than in ES cells.•MEFs…”
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Metabolic activation of diesel exhaust carcinogens in primary and immortalized human TP53 knock-in (Hupki) mouse embryo fibroblasts by Kucab, Jill E., Phillips, David H., Arlt, Volker M.

“…Approximately 50% of human tumors have a mutation in TP53. The pattern and spectra of TP53 mutations often differ between cancer types, perhaps due to…”
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Characterising Mutational Spectra of Carcinogens in the Tumour Suppressor Gene TP53 Using Human TP53 Knock-in (Hupki) Mouse Embryo Fibroblasts by Hölzl-Armstrong, Lisa, Kucab, Jill E, Korenjak, Michael, Luijten, Mirjam, Phillips, David H, Zavadil, Jiri, Arlt, Volker M

“…DNA in dividing cells is prone to mutagenesis, with mutations making key contributions to human disease including cancer. The tumour suppressor gene is the…”
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Celecoxib analogues disrupt Akt signaling, which is commonly activated in primary breast tumours by Kucab, Jill E, Lee, Cathy, Chen, Ching-Shih, Zhu, Jiuxiang, Gilks, C Blake, Cheang, Maggie, Huntsman, David, Yorida, Erika, Emerman, Joanne, Pollak, Michael, Dunn, Sandra E

“…Phosphorylated Akt (P-Akt) is an attractive molecular target because it contributes to the development of breast cancer and confers resistance to conventional…”
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Expression of the insulin-like growth factor I receptor and urokinase plasminogen activator in breast Cancer is associated with poor survival: Potential for intervention with 17-allylamino geldanamycin by NIELSEN, Torsten O, ANDREWS, Heather N, NECKERS, Leonard M, EVDOKIMOVA, Valentina, HUNTSMAN, David G, DUNN, Sandra E, CHEANG, Maggie, KUCAB, Jill E, HSU, Forrest D, RAGAZ, Joseph, GILKS, C. Blake, MAKRETSOV, Nikita, BAJDIK, Chris D, BROOKES, Christy

“…Urokinase plasminogen activator (uPA) expression in breast cancer is associated with relapse and a reduction in disease-specific survival. Thus, efforts are…”
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