Search Results - "Kubu, C J"

NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis by Salehi, A H, Roux, P P, Kubu, C J, Zeindler, C, Bhakar, A, Tannis, L L, Verdi, J M, Barker, P A

“…The mechanisms employed by the p75 neurotrophin receptor (p75NTR) to mediate neurotrophin-dependent apoptosis are poorly defined. Two-hybrid analyses were used…”
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The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation by Meakin, S O, MacDonald, J I, Gryz, E A, Kubu, C J, Verdi, J M

“…We have isolated a human cDNA for the signaling adapter molecule FRS-2/suc1-associated neurotrophic factor target and shown that it is tyrosine-phosphorylated…”
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Identification of the translational initiation codon in human MAGED1 by Kubu, C J, Goldhawk, D G, Barker, P A, Verdi, J M

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Neural Crest Stem Cells Undergo Cell-Intrinsic Developmental Changes in Sensitivity to Instructive Differentiation Signals by White, Patricia M., Morrison, Sean J., Orimoto, Kenji, Kubu, Chris J., Verdi, Joseph M., Anderson, David J.

“…Rat neural crest stem cells (NCSCs) prospectively isolated from uncultured E14.5 sciatic nerve and transplanted into chick embryos generate fewer neurons than…”
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Distinct Human NUMB Isoforms Regulate Differentiation vs. Proliferation in the Neuronal Lineage by Verdi, Joseph M., Bashirullah, Arash, Goldhawk, Donna E., Kubu, Chris J., Jamali, Mina, Meakin, Susan O., Lipshitz, Howard D.

“…Neuronal cell fate decisions are directed in Drosophila by NUMB, a signaling adapter protein with two protein-protein interaction domains: a…”
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Nesca, a Novel Adapter, Translocates to the Nuclear Envelope and Regulates Neurotrophin-Induced Neurite Outgrowth by James I. S. Mac Donald, Kubu, Chris J., Meakin, Susan O.

“…We provide the first characterization of a novel signaling adapter, Nesca, in neurotrophic signal transduction. Nesca contains a RUN domain, a WW domain, a…”
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Direct Binding of the Signaling Adapter Protein Grb2 to the Activation Loop Tyrosines on the Nerve Growth Factor Receptor Tyrosine Kinase, TrkA by MacDonald, James I.S., Gryz, Ela A., Kubu, Chris J., Verdi, Joseph M., Meakin, Susan O.

“…We demonstrate that the signaling adapter, Grb2, binds directly to the neurotrophin receptor tyrosine kinase, TrkA. Grb2 binding to TrkA is independent of Shc,…”
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Genomic organization and comparative sequence analysis of the mouse and human FRS2, FRS3 genes by Zhou, Li, McDougall, Kathryn, Kubu, Christopher J, Verdi, Joseph M, Meakin, Susan O

“…The signaling adapter proteins FRS2 and FRS3 are implicated in the transmission of extracellular signals from nerve growth factor (NGF) or fibroblast growth…”
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Developmental Changes in Notch1 and Numb Expression Mediated by Local Cell–Cell Interactions Underlie Progressively Increasing Delta Sensitivity in Neural Crest Stem Cells by Kubu, Chris J., Orimoto, Kenji, Morrison, Sean J., Weinmaster, Gerry, Anderson, David J., Verdi, Joseph M.

“…Neural stem cells become progressively less neurogenic and more gliogenic with development. Here, we show that between E10.5 and E14.5, neural crest stem cells…”
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Insulin acts as a myogenic differentiation signal for neural stem cells with multilineage differentiation potential by Bani-Yaghoub, Mahmud, Kendall, Stephen E, Moore, Daniel P, Bellum, Stephen, Cowling, Rebecca A, Nikopoulos, George N, Kubu, Chris J, Vary, Calvin, Verdi, Joseph M

“…Reports of non-neural differentiation of neural stem cells (NSCs) have been challenged by alternative explanations for expanded differentiation potentials. In…”
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