Search Results - "Kubrak, Dennis"

( S) -N-(5-Chlorothiophene-2-sulfonyl)-β,β-diethylalaninol a Notch-1-sparing γ-secretase inhibitor by Cole, Derek C., Stock, Joseph R., Kreft, Anthony F., Antane, Madelene, Aschmies, Suzan H., Atchison, Kevin P., Casebier, David S., Comery, Thomas A., Diamantidis, George, Ellingboe, John W., Harrison, Boyd L., Hu, Yun, Jin, Mei, Kubrak, Dennis M., Lu, Peimin, Mann, Charles W., Martone, Robert L., Moore, William J., Oganesian, Aram, Riddell, David R., Sonnenberg-Reines, June, Sun, Shaiu-Ching, Wagner, Erik, Wang, Zheng, Woller, Kevin R., Xu, Zheng, Zhou, Hua, Jacobsen, J. Steven

“…Accumulation of beta-amyloid (Aβ), produced by the proteolytic cleavage of amyloid precursor protein (APP) by β- and γ-secretase, is widely believed to be…”
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Etodolac selectively inhibits human prostaglandin G/H synthase 2 (PGHS-2) versus human PGHS-1 by Glaser, Keith, Sung, Mei-Li, O'Neill, Kim, Belfast, Mary, Hartman, David, Carlson, Richard, Kreft, Anthony, Kubrak, Dennis, Hsiao, Chu-Lai, Weichman, Barry

“…The isozymes of prostaglandin G/H synthase (PGHS) are shown to be differentially inhibited in vitro by currently marketed nonsteroidal anti-inflammatory drugs…”
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P2-337: Characterization of the affinity of GSI-953 for binding to gamma-secretase and comparison to benchmark gamma-secretase inhibitors by Kreft, Anthony F, Abou-Gharbia, Magid A, Aulabaugh, Ann E, Atchison, Kevin P, Diamantidis, George, Harrison, Boyd L, Hirst, Warren D, Huang, Xinyi, Kubrak, Dennis M, Lipinski, Kerri, Magolda, Ronald L, Martone, Robert L, May, Michael K, Mayer, Scott C, Pangalos, Menelas N, Porte, Alex M, Reinhart, Peter H, Resnick, Lynn, Zhou, Hua, Jacobsen, J. Steven

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Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease by Mayer, Scott C, Kreft, Anthony F, Harrison, Boyd, Abou-Gharbia, Magid, Antane, Madelene, Aschmies, Suzan, Atchison, Kevin, Chlenov, Michael, Cole, Derek C, Comery, Thomas, Diamantidis, George, Ellingboe, John, Fan, Kristi, Galante, Rocco, Gonzales, Cathleen, Ho, Douglas M, Hoke, Molly E, Hu, Yun, Huryn, Donna, Jain, Uday, Jin, Mei, Kremer, Kenneth, Kubrak, Dennis, Lin, Melissa, Lu, Peimin, Magolda, Ron, Martone, Robert, Moore, William, Oganesian, Aram, Pangalos, Menelas N, Porte, Alex, Reinhart, Peter, Resnick, Lynn, Riddell, David R, Sonnenberg-Reines, June, Stock, Joseph R, Sun, Shaiu-Ching, Wagner, Erik, Wang, Ting, Woller, Kevin, Xu, Zheng, Zaleska, Margaret M, Zeldis, Joseph, Zhang, Minsheng, Zhou, Hua, Jacobsen, J. Steven

“…SAR on HTS hits 1 and 2 led to the potent, Notch-1-sparing GSI 9, which lowered brain Aβ in Tg2576 mice at 100 mg/kg po. Converting the metabolically labile…”
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N-[(Arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure by Musser, John H, Kreft, Anthony F, Bender, Reinhold H. W, Kubrak, Dennis M, Grimes, David, Carlson, Richard P, Hand, James M, Chang, Joseph

“…Four series of N-[(arylmethoxy)phenyl] compounds were prepared as leukotriene D4 (LTD4) antagonists. In the hydroxamic acid series, methyl…”
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N-[(Arylmethoxy)phenyl] and N-[(arylmethoxy)naphthyl] sulfonamides: potent orally active leukotriene d4 antagonists of novel structure by Musser, John H, Kreft, Anthony F, Bender, Reinhold H. W, Kubrak, Dennis M, Carlson, Richard P, Chang, Joseph, Hand, James M

“…Two series of compounds, N-[(arylmethoxy)phenyl] sulfonamides and N-[(arylmethoxy)naphthyl] sulfonamides, were prepared as leukotriene D4 (LTD4) antagonists…”
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Synthesis of [[(naphthalenylmethoxy)- and -(quinolinylmethoxy)phenyl]amino]oxoalkanoic acid esters. A novel series of leukotriene D4 antagonists and 5-lipoxygenase inhibitors by Musser, John H, Kubrak, Dennis M, Chang, Joseph, Lewis, Alan J

“…A series of novel [[(naphthalenylmethoxy)- and [[(quinolinylmethoxy)phenyl]amino]oxoalkanoic acid esters have been prepared. These compounds were tested as…”
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Discovery of a novel series of Notch-sparing γ-secretase inhibitors by Kreft, Anthony, Harrison, Boyd, Aschmies, Suzan, Atchison, Kevin, Casebier, David, Cole, Derek C., Diamantidis, George, Ellingboe, John, Hauze, Diane, Hu, Yun, Huryn, Donna, Jin, Mei, Kubrak, Dennis, Lu, Peimin, Lundquist, Joseph, Mann, Charles, Martone, Robert, Moore, William, Oganesian, Aram, Porte, Alex, Riddell, Dave R., Sonnenberg-Reines, June, Stock, Joseph R., Sun, Shaiu-Ching, Wagner, Erik, Woller, Kevin, Xu, Zheng, Zhou, Hua, Steven Jacobsen, J.

“…Lead optimization studies of Notch-sparing GSI 2a led to the discovery of analog 8e with improved γ-secretase inhibitory potency and Notch-sparing selectivity…”
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Leukotriene D4 antagonists and 5-lipoxygenase inhibitors. Synthesis of benzoheterocyclic [(methoxyphenyl)amino]oxoalkanoic acid esters by Musser, John H, Kubrak, Dennis M, Chang, Joseph, DiZio, Stephen M, Hite, Mark, Hand, James M, Lewis, Alan J

“…A series of novel benzoheterocyclic [(methoxyphenyl)amino]oxoalkanoic acid esters has been prepared. These compounds were tested as inhibitors of rat…”
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Asymmetric synthesis of novel α-amino acids with β-branched side chains by Zhang, Minsheng, Porte, Alex, Diamantidis, George, Sogi, Kimberly, Kubrak, Dennis, Resnick, Lynn, Mayer, Scott C., Wang, Zheng, Kreft, Anthony F., Harrison, Boyd L.

“…An asymmetric synthesis of α-amino acids with novel β-branched side chains has been implemented. The syntheses feature a p-toluenesulfinylimine induced chiral…”
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P4-244: Discovery of a novel series of notch-sparing γ-secretase inhibitors by Harrison, Boyd L., Kreft, Anthony, Aschmies, Susan, Atchison, Kevin, Cole, Derek, Ellingboe, John, Hauze, Diane, Hu, Yun, Huryn, Donna, Jin, Mei, Kubrak, Dennis, Lu, Peimin, Mann, Charles, Martone, Robert, Moore, William, Porte, Alex, Riddell, David, Sonnenberg-Reines, June, Stock, Joseph, Sun, Shaiu-Ching, Wagner, Erik, Woller, Kevin, Xu, Zheng, Zhou, Hua, Jacobsen, Steven

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Phenylephrine derivatives as leukotriene D4 antagonists by Musser, John H, Kubrak, Dennis M, Bender, Reinhold H. W, Kreft, Anthony F, Nielsen, Susan T, Lefer, Allan M, Chang, Joseph, Lewis, Alan J, Hand, James M

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Regioselective functionalization. .beta. Substituent effects on the regioselectivity of Baeyer-Villiger oxidations of 3-substituted 2-azabicyclo[2.2.2]octan-5-ones (isoquinuclidin-5-ones) by Krow, Grant R, Johnson, Constance A, Guare, James P, Kubrak, Dennis, Henz, Kenneth J, Shaw, Donald A, Szczepanski, Steven W, Carey, James T

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