Search Results - "Kubo, Ichiro"

Increased densities of white matter neurons as a cross‐disease feature of neuropsychiatric disorders by Kubo, Ken‐ichiro

“…While neurons of the human cerebral cortex are mainly distributed in the gray matter, the white matter (WM) also contains some excitatory and inhibitory…”
Get full text

Reelin and Neuropsychiatric Disorders by Ishii, Kazuhiro, Kubo, Ken-Ichiro, Nakajima, Kazunori

“…Proper neuronal migration and laminar formation during corticogenesis is essential for normal brain function. Disruption of these developmental processes is…”
Get full text

How does Reelin control neuronal migration and layer formation in the developing mammalian neocortex? by Sekine, Katsutoshi, Kubo, Ken-ichiro, Nakajima, Kazunori

“…The mammalian neocortex has a laminar structure that develops in a birth-date-dependent "inside-out" pattern. Its layered structure is established by neuronal…”
Get full text

Characterization of the dipeptide repeat protein in the molecular pathogenesis of c9FTD/ALS by Yamakawa, Mai, Ito, Daisuke, Honda, Takao, Kubo, Ken-ichiro, Noda, Mariko, Nakajima, Kazunori, Suzuki, Norihiro

“…The expansion of the GGGGCC hexanucleotide repeat in the non-coding region of the chromosome 9 open-reading frame 72 (C9orf72) gene is the most common cause of…”
Get full text

Reelin Controls Neuronal Positioning by Promoting Cell-Matrix Adhesion via Inside-Out Activation of Integrin α5β1 by Sekine, Katsutoshi, Kawauchi, Takeshi, Kubo, Ken-ichiro, Honda, Takao, Herz, Joachim, Hattori, Mitsuharu, Kinashi, Tatsuo, Nakajima, Kazunori

“…Birthdate-dependent neuronal layering is fundamental to neocortical functions. The extracellular protein Reelin is essential for the establishment of the…”
Get full text

Rab GTPases-Dependent Endocytic Pathways Regulate Neuronal Migration and Maturation through N-Cadherin Trafficking by Kawauchi, Takeshi, Sekine, Katsutoshi, Shikanai, Mima, Chihama, Kaori, Tomita, Kenji, Kubo, Ken-ichiro, Nakajima, Kazunori, Nabeshima, Yo-ichi, Hoshino, Mikio

“…Although membrane trafficking pathways are involved in basic cellular functions, the evolutionally expanded number of their related family proteins suggests…”
Get full text

Both excitatory and inhibitory neurons transiently form clusters at the outermost region of the developing mammalian cerebral neocortex by Shin, Minkyung, Kitazawa, Ayako, Yoshinaga, Satoshi, Hayashi, Kanehiro, Hirata, Yukio, Dehay, Colette, Kubo, Ken‐ichiro, Nakajima, Kazunori

“…During development of the mammalian cerebral neocortex, postmitotic excitatory neurons migrate toward the outermost region of the neocortex. We previously…”
Get full text

A Unique "Reversed" Migration of Neurons in the Developing Claustrum by Oshima, Kota, Yoshinaga, Satoshi, Kitazawa, Ayako, Hirota, Yuki, Nakajima, Kazunori, Kubo, Ken-Ichiro

“…The claustrum (CLA) is a cluster of neurons located between the insular cortex and striatum. Many studies have shown that the CLA plays an important role in…”
Get full text

Rhythmic activation of excitatory neurons in the mouse frontal cortex improves the prefrontal cortex-mediated cognitive function by Hazra, Debabrata, Yoshinaga, Satoshi, Yoshida, Keitaro, Takata, Norio, Tanaka, Kenji F, Kubo, Ken-Ichiro, Nakajima, Kazunori

“…The prefrontal cortex (PFC) plays essential roles in cognitive processes. Previous studies have suggested the layer and the cell type-specific activation for…”
Get full text

Human neocortical development as a basis to understand mechanisms underlying neurodevelopmental disabilities in extremely preterm infants by Kubo, Ken‐ichiro, Deguchi, Kimiko

“…Aim Recent advances in perinatal and neonatal medicine have resulted in marked improvements in the survival rates of extremely preterm infants (born before 28…”
Get full text

Importance of Reelin C-terminal region in the development and maintenance of the postnatal cerebral cortex and its regulation by specific proteolysis by Kohno, Takao, Honda, Takao, Kubo, Ken-Ichiro, Nakano, Yoshimi, Tsuchiya, Ayaka, Murakami, Tatsuro, Banno, Hideyuki, Nakajima, Kazunori, Hattori, Mitsuharu

“…During brain development, Reelin exerts a variety of effects in a context-dependent manner, whereas its underlying molecular mechanisms remain poorly…”
Get full text

Pathogenesis of familial Parkinson's disease: new insights based on monogenic forms of Parkinson's disease by Hatano, Taku, Kubo, Shin-ichiro, Sato, Shigeto, Hattori, Nobutaka

“…Parkinson's disease (PD) is one of the most common movement disorders caused by the loss of dopaminergic neuronal cells. The molecular mechanisms underlying…”
Get full text

Membrane lipids as therapeutic targets for Parkinson's disease: a possible link between Lewy pathology and membrane lipids by Kubo, Shin-Ichiro

“…Pathologically, Parkinson's disease (PD) is characterized by nigral cell loss and Lewy pathology in the remaining neurons. Whereas the motor symptoms of PD…”
Get more information

Drebrin-like (Dbnl) Controls Neuronal Migration via Regulating N-Cadherin Expression in the Developing Cerebral Cortex by Inoue, Seika, Hayashi, Kanehiro, Fujita, Kyota, Tagawa, Kazuhiko, Okazawa, Hitoshi, Kubo, Ken-Ichiro, Nakajima, Kazunori

“…The actin cytoskeleton is crucial for neuronal migration in the mammalian developing cerebral cortex. The adaptor protein Drebrin-like (Dbnl) plays important…”
Get full text

Reelin receptors ApoER2 and VLDLR are expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex by Hirota, Yuki, Kubo, Ken-ichiro, Katayama, Kei-ichi, Honda, Takao, Fujino, Takahiro, Yamamoto, Tokuo T., Nakajima, Kazunori

“…ABSTRACT In mammalian developing brain, neuronal migration is regulated by a variety of signaling cascades, including Reelin signaling. Reelin is a…”
Get full text

Reelin transiently promotes N-cadherin–dependent neuronal adhesion during mouse cortical development by Matsunaga, Yuki, Noda, Mariko, Murakawa, Hideki, Hayashi, Kanehiro, Nagasaka, Arata, Inoue, Seika, Miyata, Takaki, Miura, Takashi, Kubo, Ken-ichiro, Nakajima, Kazunori

“…Reelin is an essential glycoprotein for the establishment of the highly organized six-layered structure of neurons of the mammalian neocortex. Although the…”
Get full text

Knockdown of DISC1 by In Utero Gene Transfer Disturbs Postnatal Dopaminergic Maturation in the Frontal Cortex and Leads to Adult Behavioral Deficits by Niwa, Minae, Kamiya, Atsushi, Murai, Rina, Kubo, Ken-ichiro, Gruber, Aaron J., Tomita, Kenji, Lu, Lingling, Tomisato, Shuta, Jaaro-Peled, Hanna, Seshadri, Saurav, Hiyama, Hideki, Huang, Beverly, Kohda, Kazuhisa, Noda, Yukihiro, O'Donnell, Patricio, Nakajima, Kazunori, Sawa, Akira, Nabeshima, Toshitaka

“…Adult brain function and behavior are influenced by neuronal network formation during development. Genetic susceptibility factors for adult psychiatric…”
Get full text

Hippocampal pyramidal neurons switch from a multipolar migration mode to a novel "climbing" migration mode during development by Kitazawa, Ayako, Kubo, Ken-ichiro, Hayashi, Kanehiro, Matsunaga, Yuki, Ishii, Kazuhiro, Nakajima, Kazunori

“…The hippocampus plays important roles in brain functions. Despite the importance of hippocampal functions, recent analyses of neuronal migration have mainly…”
Get full text

Disrupted-in-Schizophrenia-1 (Disc1) is necessary for migration of the pyramidal neurons during mouse hippocampal development by Tomita, Kenji, Kubo, Ken-ichiro, Ishii, Kazuhiro, Nakajima, Kazunori

“…The hippocampus has a highly ordered structure and is composed of distinct layers. Neuronal migration is an essential part of the process of the layer…”
Get full text

A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development by Sawa, Akira, Kamiya, Atsushi, Kubo, Ken-ichiro, Tomoda, Toshifumi, Takaki, Manabu, Youn, Richard, Ozeki, Yuji, Sawamura, Naoya, Park, Una, Kudo, Chikako, Okawa, Masako, Ross, Christopher A, Hatten, Mary E, Nakajima, Kazunori

“…Disrupted-In-Schizophrenia-1 (DISC1), originally identified at the breakpoint of a chromosomal translocation that is linked to a rare familial schizophrenia,…”
Get full text