Search Results - "Kubik, Jacy"

Ethanol withdrawal mitigates fatty liver by normalizing lipid catabolism by Thomes, Paul G, Rasineni, Karuna, Yang, Li, Donohue, Jr, Terrence M, Kubik, Jacy L, McNiven, Mark A, Casey, Carol A

“…We are investigating the changes in hepatic lipid catabolism that contribute to alcohol-induced fatty liver. Following chronic ethanol (EtOH) exposure,…”
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Chronic alcohol exposure alters circulating insulin and ghrelin levels: role of ghrelin in hepatic steatosis by Rasineni, Karuna, Thomes, Paul G, Kubik, Jacy L, Harris, Edward N, Kharbanda, Kusum K, Casey, Carol A

“…Fatty liver is the earliest response of the liver to excessive ethanol consumption. Central in the development of alcoholic steatosis is increased mobilization…”
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Lipid droplet membrane proteome remodeling parallels ethanol-induced hepatic steatosis and its resolution by Casey, Carol A., Donohue, Terrence M., Kubik, Jacy L., Kumar, Vikas, Naldrett, Michael J., Woods, Nicholas T., Frisbie, Cole P., McNiven, Mark A., Thomes, Paul G.

“…Lipid droplets (LDs) are composed of neutral lipids enclosed in a phospholipid monolayer, which harbors membrane-associated proteins that regulate LD…”
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Ghrelin regulates adipose tissue metabolism: Role in hepatic steatosis by Rasineni, Karuna, Kubik, Jacy L., Knight, Kurt L., Hall, Lukas, Casey, Carol A., Kharbanda, Kusum K.

“…Fatty liver is the earliest and most common response of the liver to consumption of excessive alcohol. Steatosis can predispose the fatty liver to develop…”
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Hydroxysteroid 17β-dehydrogenase 11 accumulation on lipid droplets promotes ethanol-induced cellular steatosis by Thomes, Paul G., Strupp, Michael S., Donohue, Terence M., Kubik, Jacy L., Sweeney, Sarah, Mahmud, R., Schott, Micah B., Schulze, Ryan J., McNiven, Mark A., Casey, Carol A.

“…Lipid droplets (LDs) are fat-storing organelles enclosed by a phospholipid monolayer, which harbors membrane-associated proteins that regulate distinct LD…”
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Contrasting Effects of Fasting on Liver-Adipose Axis in Alcohol-Associated and Non-alcoholic Fatty Liver by Rasineni, Karuna, Jordan, Clayton W, Thomes, Paul G, Kubik, Jacy L, Staab, Elizabeth M, Sweeney, Sarah A, Talmon, Geoffrey A, Donohue, Terrence M, McNiven, Mark A, Kharbanda, Kusum K, Casey, Carol A

“…Fatty liver, a major health problem worldwide, is the earliest pathological change in the progression of alcohol-associated (AFL) and non-alcoholic fatty liver…”
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Inhibition of Ghrelin Activity by Receptor Antagonist [d-Lys-3] GHRP-6 Attenuates Alcohol-Induced Hepatic Steatosis by Regulating Hepatic Lipid Metabolism by Rasineni, Karuna, Kubik, Jacy L, Casey, Carol A, Kharbanda, Kusum K

“…Alcoholic steatosis, characterized by an accumulation of triglycerides in hepatocytes, is one of the earliest pathological changes in the progression of…”
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Multiomics Approach Captures Hepatic Metabolic Network Altered by Chronic Ethanol Administration by Sakallioglu, Isin Tuna, Tripp, Bridget, Kubik, Jacy, Casey, Carol A, Thomes, Paul, Powers, Robert

“…Using a multiplatform and multiomics approach, we identified metabolites, lipids, proteins, and metabolic pathways that were altered in the liver after chronic…”
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Enhanced colorectal cancer metastases in the alcohol-injured liver by Mohr, Ashley M., Gould, John J., Kubik, Jacy L., Talmon, Geoffrey A., Casey, Carol A., Thomas, Peter, Tuma, Dean J., McVicker, Benita L.

“…Metastatic liver disease is a major cause of mortality in colorectal cancer (CRC) patients. Alcohol consumption is a noted risk factor for secondary cancers…”
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Alcohol‐Induced Liver Injury: Down‐regulation and Redistribution of Rab3D Results in Atypical Protein Trafficking by Casey, Carol A., Macke, Amanda J., Gough, Ryan R., Pachikov, Artem N., Morris, Mary E., Thomes, Paul G., Kubik, Jacy L., Holzapfel, Melissa S., Petrosyan, Armen

“…Previous work from our laboratories has identified multiple defects in endocytosis, protein trafficking, and secretion, along with altered Golgi function after…”
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Ethanol-Induced Apoptosis in Polarized Hepatic Cells Possibly Through Regulation of the Fas Pathway by McVicker, Benita L., Tuma, Dean J., Kubik, Jacy L., Tuma, Pamela L., Casey, Carol A.

“…Background: It has been noted that alcohol‐related liver diseases can be associated with an increase in apoptotic hepatocellular death. Moreover, the promotion…”
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Impaired Protein Trafficking and Elevated Triglycerides in a Mouse Model of Ethanol Administration by Lazure, Kathryn E, Kubik, Jacy L, Rasineni, Karuna, McVicker, Benita, Casey, Carol A

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Natural Recovery by the Liver and Other Organs after Chronic Alcohol Use by Thomes, Paul G, Rasineni, Karuna, Saraswathi, Viswanathan, Kharbanda, Kusum K, Clemens, Dahn L, Sweeney, Sarah A, Kubik, Jacy L, Donohue, Jr, Terrence M, Casey, Carol A

“…Chronic, heavy alcohol consumption disrupts normal organ function and causes structural damage in virtually every tissue of the body. Current diagnostic…”
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Effect of Chronic Ethanol Administration on the in Vitro Production of Proinflammatory Cytokines by Rat Kupffer Cells in the Presence of Apoptotic Cells by McVicker, Benita L., Tuma, Dean J., Kharbanda, Kusum K., Kubik, Jacy L., Casey, Carol A.

“…Background: Chronic ethanol consumption can lead to a variety of pathological consequences by as yet undefined mechanisms. Recently, it has been noted that…”
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The effect of ethanol on asialoglycoprotein receptor—mediated phagocytosis of apoptotic cells by rat hepatocytes by McVicker, Benita L., Tuma, Dean J., Kubik, Jacy A., Hindemith, Agnes M., Baldwin, Cheryl R., Casey, Carol A.

“…Apoptotic cell death is a well‐defined process that is controlled by intrinsic cellular mechanisms followed by the generation of apoptotic bodies and their…”
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Use of Flow Cytometric Analysis to Examine the Uptake of Apoptotic Bodies by Healthy Hepatocytes by Casey, Carol A, Baldwin, Cheryl R, Kubik, Jacy L, Hindemith, Agnes M, McVicker, Benita L

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The effect of ethanol on asialoglycoprotein receptor–mediated phagocytosis of apoptotic cells by rat hepatocytes by McVicker, Benita L., Tuma, Dean J., Kubik, Jacy A., Hindemith, Agnes M., Baldwin, Cheryl R., Casey, Carol A.

“…Apoptotic cell death is a well-defined process that is controlled by intrinsic cellular mechanisms followed by the generation of apoptotic bodies and their…”
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The Growth Factor from Plerocercoids of Spirometra mansonoides Is Both a Growth Hormone Agonist and a Cysteine Proteinase by Phares, Kirk, Kubik, Jacy

“…Plerocercoids of the tapeworm Spirometra mansonoides produce a substance that stimulates growth of experimental hosts. We report purification of plerocercoid…”
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