The effects of cholecystokinin on stimulation-induced feeding and self-stimulation

Cholecystokinin (CCK) is a peptide hormone which controls a number of important functions during the process of digestion. It is present in the gut and the central nervous system, although its exact role in the latter is not yet clear. Our interest was in the effects of intraperitoneal and intracere...

Full description

Saved in:

Bibliographic Details
Published in:	Behavioural brain research Vol. 107; no. 1; pp. 145 - 152
Main Authors:	Konkle, Anne T.M, Kubelka, Shannon L, Bielajew, Catherine
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier B.V 2000 Elsevier Science
Subjects:	Animals Behavioral psychophysiology Biological and medical sciences Brain Mapping Brain stimulation reward Cholecystokinin Cholecystokinin - physiology Efficiency of food utilization Energy Metabolism - physiology Feeding Behavior - physiology Fundamental and applied biological sciences. Psychology Hypothalamic Area, Lateral - physiology Intracerebral injections Lateral hypothalamus Male Motivation Nerve Net - physiology Neurotransmission and behavior Peripheral injections Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Self Stimulation - physiology Stimulation-induced feeding Efficiency of food utilization Intracerebral injections Brain stimulation reward Stimulation-induced feeding Lateral hypothalamus Cholecystokinin Peripheral injections Feeding behavior Positive reinforcement Rat Rodentia Central nervous system Male Neuropeptide Feeding Vertebrata Mammalia Food intake Animal Self stimulation Brain (vertebrata)
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Cholecystokinin (CCK) is a peptide hormone which controls a number of important functions during the process of digestion. It is present in the gut and the central nervous system, although its exact role in the latter is not yet clear. Our interest was in the effects of intraperitoneal and intracerebral injections of CCK on brain stimulation reward and stimulation-induced feeding. Period thresholds for rewarding stimulation were unaffected by either route of peptide administration, whereas stimulation-induced feeding thresholds were weakly increased by centrally injected CCK. In addition, we evaluated stimulation-induced feeding using a more resolved measure and found it to provide clearer results. By actually measuring the amount of food eaten during a stimulation-induced feeding session, and not only the occurrence of feeding, CCK was shown to systematically decrease the total intake as a function of dose in an inverse manner. The efficiency of food utilization was calculated for each animal during the different phases of the experiment in order to monitor the effects of CCK on the animals’ overall health. Centrally administered CCK appeared to increase the animals’ efficiency and, furthermore, this level was sustained for the entire post-injection phase, about 2 weeks, suggesting a relatively enduring increase in metabolic rate. While the functional role of central CCK and other gastric peptides requires clarification, analyses which exploit the stimulation-induced feeding paradigm need to make use of more clearly defined microstructural variables.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0166-4328 1872-7549
DOI:	10.1016/S0166-4328(99)00126-6