Search Results - "Kubek, Katie"

Application of tail vein serial microsampling for plasma or dried plasma spots in toxicokinetic assessment in rats using acetaminophen as the model compound by Li, Wenkui, Dugyala, Ravi, Devine, Patrick J., Jardel, Matthew, Doherty, John, Kubek, Katie, Lapadula, Daniel, Flarakos, Jimmy

“…In the current study, two groups of rats (five per group) were administered a single oral dose of 500 mg/kg acetaminophen. For toxicokinetic assessment, the…”
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The LXR agonist TO901317 selectively lowers hippocampal Aβ42 and improves memory in the Tg2576 mouse model of Alzheimer's disease by Riddell, David R., Zhou, Hua, Comery, Thomas A., Kouranova, Evguenia, Lo, C. Frederick, Warwick, Helen K., Ring, Robert H., Kirksey, Yolanda, Aschmies, Suzan, Xu, Jane, Kubek, Katie, Hirst, Warren D., Gonzales, Catherine, Chen, Yi, Murphy, Erin, Leonard, Sarah, Vasylyev, Dmytro, Oganesian, Aram, Martone, Robert L., Pangalos, Menelas N., Reinhart, Peter H., Jacobsen, J. Steve

“…Recent studies show that intracellular cholesterol levels can modulate the processing of amyloid precursor protein to Aβ peptide. Moreover, cholesterol-rich…”
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Amiloride is neuroprotective in an MPTP model of Parkinson's disease by Arias, Robert L, Sung, Mei-Li A, Vasylyev, Dmytro, Zhang, Mei-Yi, Albinson, Kristin, Kubek, Katie, Kagan, Natasha, Beyer, Chad, Lin, Qian, Dwyer, Jason M, Zaleska, Margaret M, Bowlby, Mark R, Dunlop, John, Monaghan, Michael

“…Abstract The diuretic amiloride has recently proven neuroprotective in models of cerebral ischemia, a property attributable to the drug's inhibition of central…”
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Amyloid beta induces changes in NMDA and AMPA receptor trafficking in primary neuronal cultures and brain slices by Hirst, Warren D, Kubek, Katie E, Golembieski, Jeannette, Staal, Roland G.W, Pangalos, Menelas N, Reinhart, Peter H, Braithwaite, Stephen P

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Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod and its lack of relevance to rat and human by Pognan, Francois, Mahl, J. Andreas, Papoutsi, Maria, Ledieu, David, Raccuglia, Marc, Theil, Diethilde, Voytek, Sarah B., Devine, Patrick J., Kubek-Luck, Katie, Claudio, Natalie, Cordier, Andre, Heier, Annabelle, Kolly, Carine, Hartmann, Andreas, Chibout, Salah-Dine, Bouchard, Page, Trendelenburg, Christian

“…A high incidence of hemangiosarcoma (HSA) was observed in mice treated for 2 years with siponimod, a sphingosine-1-phosphate receptor 1 (S1P1) functional…”
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The LXR agonist TO901317 selectively lowers hippocampal A beta 42 and improves memory in the Tg2576 mouse model of Alzheimer's disease by Riddell, DR, Zhou, H, Comery, T A, Kouranova, E, Lo, C F, Warwick, H K, Ring, R H, Kirksey, Y, Aschmies, S, Xu, J, Kubek, K, Hirst, W D, Gonzales, C, Chen, Y, Murphy, E, Leonard, S, Vasylyev, D, Oganesian, A, Martone, R L, Pangalos, M N, Reinhart, PH, Jacobsen, J S

“…Recent studies show that intracellular cholesterol levels can modulate the processing of amyloid precursor protein to A beta peptide. Moreover,…”
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Benzimidazole- and indole-substituted 1,3′-bipyrrolidine benzamides as histamine H 3 receptor antagonists by Cole, Derek C., Gross, Jonathan L., Comery, Thomas A., Aschmies, Suzan, Hirst, Warren D., Kelley, Cody, Kim, Ji-In, Kubek, Katie, Ning, Xiaoping, Platt, Brian J., Robichaud, Albert J., Solvibile, William R., Stock, Joseph R., Tawa, Gregory, Williams, Marla J., Ellingboe, John W.

“…Using a focused screen of biogenic amine compounds a novel series of H 3R antagonists was identified. Preliminary SAR led to reduction of MW while increasing…”
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Benzimidazole- and indole-substituted 1,3'-bipyrrolidine benzamides as histamine H3 receptor antagonists by COLE, Derek C, GROSS, Jonathan L, ROBICHAUD, Albert J, SOLVIBILE, William R, STOCK, Joseph R, TAWA, Gregory, WILLIAMS, Marla J, ELLINGBOE, John W, COMERY, Thomas A, ASCHMIES, Suzan, HIRST, Warren D, KELLEY, Cody, KIM, Ji-In, KUBEK, Katie, XIAOPING NING, PLATT, Brian J

“…Using a focused screen of biogenic amine compounds we identified a novel series of H(3)R antagonists. A preliminary SAR study led to reduction of MW while…”
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P3‐293: Investigation of the critical amino acids in the BACE1 binding site that interact with small molecule inhibitors using a novel radioligand and X‐ray crystallography by Hirst, Warren D., Kubek, Katie, Bard, Jonathan, Turner, James, Fan, Kristi, Malamas, Michael, Reinhart, Peter H., Robichaud, Albert J.

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P2‐147: Amyloid beta induces changes in NMDA and AMPA receptor trafficking in primary neuronal cultures and brain slices by Hirst, Warren D., Kubek, Katie E., Golembieski, Jeannette, Staal, Roland G.W., Pangalos, Menelas N., Reinhart, Peter H., Braithwaite, Stephen P.

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2-(Pyrrolidin-1-yl)ethyl-3,4-dihydroisoquinolin-1(2H)-one Derivatives as Potent and Selective Histamine-3 Receptor Antagonists by Zhou, Dahui, Gross, Jonathan L, Adedoyin, Adedayo B, Aschmies, Suzan B, Brennan, Julie, Bowlby, Mark, Di, Li, Kubek, Katie, Platt, Brian J, Wang, Zheng, Zhang, Guoming, Brandon, Nicholas, Comery, Thomas A, Robichaud, Albert J

“…On the basis of the previously reported benzimidazole 1,3′-bipyrrolidine benzamides (1), a new class of…”
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Investigation of the critical amino acids in the BACE1 binding site that interact with small molecule inhibitors using a novel radioligand and X-ray crystallography by Hirst, Warren D, Kubek, Katie, Bard, Jonathan, Turner, James, Fan, Kristi, Malamas, Michael, Reinhart, Peter H, Robichaud, Albert J

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Benzimidazole- and indole-substituted 1,3'-bipyrrolidine benzamides as histamine H sub(3) receptor antagonists by Cole, Derek C, Gross, Jonathan L, Comery, Thomas A, Aschmies, Suzan, Hirst, Warren D, Kelley, Cody, Kim, Ji-In, Kubek, Katie, Ning, Xiaoping, Platt, Brian J, Robichaud, Albert J, Solvibile, William R, Stock, Joseph R, Tawa, Gregory, Williams, Marla J, Ellingboe, John W

“…Using a focused screen of biogenic amine compounds we identified a novel series of H sub(3)R antagonists. A preliminary SAR study led to reduction of MW while…”
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Social odor recognition: a novel behavioral model for cognitive dysfunction in Parkinson's disease by Monaghan, Michael M, Leddy, Lauren, Sung, Mei-Li Amy, Albinson, Kristin, Kubek, Katie, Pangalos, Menelas N, Reinhart, Peter H, Zaleska, Margaret M, Comery, Thomas A

“…Parkinson's disease (PD) is a progressive neurodegenerative condition characterized by an increasing loss of dopaminergic neurons resulting in motor…”
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The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease by Riddell, David R, Zhou, Hua, Comery, Thomas A, Kouranova, Evguenia, Lo, C Frederick, Warwick, Helen K, Ring, Robert H, Kirksey, Yolanda, Aschmies, Suzan, Xu, Jane, Kubek, Katie, Hirst, Warren D, Gonzales, Catherine, Chen, Yi, Murphy, Erin, Leonard, Sarah, Vasylyev, Dmytro, Oganesian, Aram, Martone, Robert L, Pangalos, Menelas N, Reinhart, Peter H, Jacobsen, J Steve

“…Recent studies show that intracellular cholesterol levels can modulate the processing of amyloid precursor protein to Abeta peptide. Moreover, cholesterol-rich…”
Get full text