Search Results - "Kuba, Maria G"

Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors by Chakrabarty, Anindita, Sánchez, Violeta, Kuba, María G, Rinehart, Cammie, Arteaga, Carlos L

“…We examined the effects of an inhibitor of PI3K, XL147, against human breast cancer cell lines with constitutive PI3K activation. Treatment with XL147 resulted…”
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A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer by FOX, Emily M, MILLER, Todd W, SHYR, Yu, MANNING, H. Charles, BUCK, Elizabeth, ARTEAGA, Carlos L, BALKO, Justin M, KUBA, Maria G, SANCHEZ, Violeta, ADAM SMITH, R, SHUYING LIU, GONZALEZ-ANGULO, Ana Maria, MILLS, Gordon B, FEI YE

“…Estrogen receptor α (ER)-positive breast cancers adapt to hormone deprivation and become resistant to antiestrogens. In this study, we sought to identify…”
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Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance by Balko, Justin M, Cook, Rebecca S, Vaught, David B, Kuba, María G, Miller, Todd W, Bhola, Neil E, Sanders, Melinda E, Granja-Ingram, Nara M, Smith, J Joshua, Meszoely, Ingrid M, Salter, Janine, Dowsett, Mitch, Stemke-Hale, Katherine, González-Angulo, Ana M, Mills, Gordon B, Pinto, Joseph A, Gómez, Henry L, Arteaga, Carlos L

“…By digital profiling of residual breast tumors after neoadjuvant therapy, the authors identify gene expression patterns that correspond with a higher risk of…”
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Histopathologic Grading Is of Prognostic Significance in Primary Angiosarcoma of Breast: Proposal of a Simplified 2-tier Grading System by Kuba, Maria G., Dermawan, Josephine K., Xu, Bin, Singer, Samuel, Plitas, George, Tap, William D., D’Angelo, Sandra P., Rosenbaum, Evan, Brogi, Edi, Antonescu, Cristina R.

“…Despite a wide spectrum of clinical presentations, including primary or secondary, most angiosarcomas are considered high grade. One exception is primary…”
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Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets by Balko, Justin M, Giltnane, Jennifer M, Wang, Kai, Schwarz, Luis J, Young, Christian D, Cook, Rebecca S, Owens, Phillip, Sanders, Melinda E, Kuba, Maria G, Sánchez, Violeta, Kurupi, Richard, Moore, Preston D, Pinto, Joseph A, Doimi, Franco D, Gómez, Henry, Horiuchi, Dai, Goga, Andrei, Lehmann, Brian D, Bauer, Joshua A, Pietenpol, Jennifer A, Ross, Jeffrey S, Palmer, Gary A, Yelensky, Roman, Cronin, Maureen, Miller, Vincent A, Stephens, Phillip J, Arteaga, Carlos L

“…Neoadjuvant chemotherapy (NAC) induces a pathologic complete response (pCR) in approximately 30% of patients with triple-negative breast cancers (TNBC). In…”
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ERα-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer by Miller, Todd W, Balko, Justin M, Fox, Emily M, Ghazoui, Zara, Dunbier, Anita, Anderson, Helen, Dowsett, Mitch, Jiang, Aixiang, Smith, R Adam, Maira, Sauveur-Michel, Manning, H Charles, González-Angulo, Ana M, Mills, Gordon B, Higham, Catherine, Chanthaphaychith, Siprachanh, Kuba, Maria G, Miller, William R, Shyr, Yu, Arteaga, Carlos L

“…Most estrogen receptor α (ER)-positive breast cancers initially respond to antiestrogens, but many eventually become estrogen-independent and recur. We…”
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Lactate Dehydrogenase B: A Metabolic Marker of Response to Neoadjuvant Chemotherapy in Breast Cancer by DENNISON, Jennifer B, MOLINA, Jennifer R, BROWN, Robert E, MILLS, Gordon B, MITRA, Shreya, GONZALEZ-ANGULO, Ana M, BALKO, Justin M, KUBA, María G, SANDERS, Melinda E, PINTO, Joseph A, GOMEZ, Henry L, ARTEAGA, Carlos L

“…Although breast cancers are known to be molecularly heterogeneous, their metabolic phenotype is less well-understood and may predict response to chemotherapy…”
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ErbB3 downregulation enhances luminal breast tumor response to antiestrogens by Morrison, Meghan M, Hutchinson, Katherine, Williams, Michelle M, Stanford, Jamie C, Balko, Justin M, Young, Christian, Kuba, Maria G, Sánchez, Violeta, Williams, Andrew J, Hicks, Donna J, Arteaga, Carlos L, Prat, Aleix, Perou, Charles M, Earp, H Shelton, Massarweh, Suleiman, Cook, Rebecca S

“…Aberrant regulation of the erythroblastosis oncogene B (ErbB) family of receptor tyrosine kinases (RTKs) and their ligands is common in human cancers. ErbB3 is…”
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Lethal neonatal meningoencephalitis caused by multi-drug resistant, highly virulent Escherichia coli by Iqbal, Junaid, Dufendach, Kevin R, Wellons, John C, Kuba, Maria G, Nickols, Hilary H, Gómez-Duarte, Oscar G, Wynn, James L

“…Neonatal meningitis is a rare but devastating condition. Multi-drug resistant (MDR) bacteria represent a substantial global health risk. This study reports on…”
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Conditional Loss of ErbB3 Delays Mammary Gland Hyperplasia Induced by Mutant PIK3CA without Affecting Mammary Tumor Latency, Gene Expression, or Signaling by YOUNG, Christian D, PFEFFERLE, Adam D, COOK, Rebecca S, ARTEAGA, Carlos L, OWENS, Philip, KUBA, María G, REXER, Brent N, BALKO, Justin M, SANCHEZ, Violeta, HAILING CHENG, PEROU, Charles M, ZHAO, Jean J

“…Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of phosphoinositide 3-kinase (PI3K), have been shown to transform mammary epithelial cells…”
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Primary Carcinoid Tumor of the Renal Pelvis Arising From Intestinal Metaplasia: An Unusual Histogenetic Pathway? by Kuba, Maria G, Wasserman, Allison, Vnencak-Jones, Cindy L, Bridge, Julia A, Gellert, Lan, Hameed, Omar, Giannico, Giovanna A

“…Primary carcinoid tumor of the renal pelvis is a rare neoplasm with few cases reported in the literature. Here we present the clinical and histopathologic…”
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Discordant cellular response to presurgical letrozole in bilateral synchronous ER+ breast cancers with a KRAS mutation or FGFR1 gene amplification by Balko, Justin M, Mayer, Ingrid A, Sanders, Melinda E, Miller, Todd W, Kuba, Maria G, Meszoely, Ingrid M, Wagle, Nikhil, Garraway, Levi A, Arteaga, Carlos L

“…We describe herein a patient presenting with bilateral estrogen-receptor-positive (ER+) breast tumors who was enrolled in a clinical trial exploring molecular…”
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Histopathologic Grading Is of Prognostic Significance in Primary Angiosarcoma of Breast: Proposal of a Simplified 2-tier Grading System by Kuba, Maria G., Dermawan, Josephine K., Xu, Bin, Singer, Samuel, Plitas, George, Tap, William D., D’Angelo, Sandra P., Rosenbaum, Evan, Brogi, Edi, Antonescu, Cristina R.

“…Despite a wide spectrum of clinical presentations, including primary or secondary, most angiosarcomas are considered high grade. One exception is primary…”
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Abstract 4698: Gene expression profiles of triple negative breast cancer epithelial and stromal cells are predictive of treatment response by Jovanovic, Bojana, Chen, Steven X., Lehmann, Brian D., Johnson, Kimberly N., Sanchez, Violeta, Kuba, Maria G., Sanders, Melinda E., Mayer, Ingrid A., Moses, Harold L., Pietenpol, Jennifer A.

“…Abstract Lacking human epithelial growth factor receptor 2 (HER2) amplification as well as estrogen and progesterone receptors, TNBC is a heterogeneous…”
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Abstract LB-103: Conditional loss of ErbB3 delays mammary gland hyperplasias induced by mutant PIK3CA in transgenic mice, but does not affect mammary tumor latency, gene expression or signaling by Young, Christian D., Kuba, Maria G., Owens, Philip, Balko, Justin M., Pfefferle, Adam, Sanchez, Violeta, Perou, Charles M., Zhao, Jean J., Cook, Rebecca S., Arteaga, Carlos L.

“…Abstract The phosphatidylinositol-3-kinase (PI3K) pathway is the most frequently mutated pathway in breast cancer. Signaling through the ErbB family of…”
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Abstract 4875: Human HER2 and PI3K H1047R cooperate to promote mammary tumorigenesis in vivo by Hanker, Ariella B., Kuba, Maria G., Sanchez, Violeta, Sutton, Cammie R., Pfefferle, Adam, Balko, Justin M., Perou, Charles M., Cook, Rebecca S., Arteaga, Carlos L.

“…Abstract The HER2 oncogene is amplified in 20-25% of breast cancers and is associated with poor patient outcome. Mutational activation of PIK3CA, the gene…”
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Discordant cellular response to pre-surgical letrozole in bilateral synchronous ER+ breast cancers with a KRAS mutation or FGFR1 gene amplification by Balko, Justin M., Mayer, Ingrid A., Sanders, Melinda E., Miller, Todd W., Kuba, Maria G., Meszoely, Ingrid M., Wagle, Nikhil, Garraway, Levi A., Arteaga, Carlos L.

“…We describe herein a patient presenting with bilateral ER+ breast tumors who was enrolled in a clinical trial exploring molecular aberrations associated with…”
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A kinome-wide screen identifies the Insulin/IGF-1 receptor pathway as a mechanism of escape from hormone dependence in breast cancer by Fox, Emily M., Miller, Todd W., Balko, Justin M., Kuba, Maria G., Sánchez, Violeta, Smith, R. Adam, Liu, Shuying, González-Angulo, Ana María, Mills, Gordon B., Ye, Fei, Shyr, Yu, Manning, H. Charles, Buck, Elizabeth, Arteaga, Carlos L.

“…Estrogen receptor α (ER)-positive breast cancers adapt to hormone deprivation and become resistant to antiestrogens. In this study, we sought to identify…”
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Lethal neonatal meningoencephalitis caused by multi-drug resistant, highly virulent Escherichia coli by Iqbal, Junaid, Dufendach, Kevin R., Wellons, John C., Kuba, Maria G., Nickols, Hilary H., Gómez-Duarte, Oscar G., Wynn, James L.

“…Neonatal meningitis is a rare but devastating condition. Multi-drug resistant (MDR) bacteria represent a substantial global health risk. This study reports on…”
Get full text