Search Results - "Kuang, Yeye"

Forkhead box E1, frequently downregulted by promoter methylation, inhibits colorectal cancer cell growth and migration by Shi, Qinlan, Huang, Zhongting, Kuang, Yeye, Wang, Chan, Fang, Xiao, Hu, Xiaotong

“…Forkhead box E1 (FOXE1), also known as thyroid transcription factor 2 (TTF-2), belongs to a large family of forkhead transcription factors. It plays important…”
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Protocadherin 17 acts as a tumour suppressor inducing tumour cell apoptosis and autophagy, and is frequently methylated in gastric and colorectal cancers by Hu, Xiaotong, Sui, Xinbing, Li, Lili, Huang, Xuefeng, Rong, Rong, Su, Xianwei, Shi, Qinglan, Mo, Lijuan, Shu, Xingsheng, Kuang, Yeye, Tao, Qian, He, Chao

“…Gastric and colorectal cancers are among the most common cancers worldwide and cause serious cancer mortality. Both epigenetic and genetic disruptions of…”
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CHAC2, downregulated in gastric and colorectal cancers, acted as a tumor suppressor inducing apoptosis and autophagy through unfolded protein response by Liu, Shuiping, Fei, Weiqiang, Shi, Qinglan, Li, Qiang, Kuang, Yeye, Wang, Chan, He, Chao, Hu, Xiaotong

“…Tumor suppressor genes play a key role in cancer pathogenesis. Through massive expression profiling we identified CHAC2 as a frequently downregulated gene in…”
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IRS1 promotes thyroid cancer metastasis through EMT and PI3K/AKT pathways by Yu, Fang, Huang, Dongdong, Kuang, Yeye, Dong, Jian, Han, Qingmei, Zhou, Jie, Teng, Xiaodong

“…Objective Insulin receptor substract 1 (IRS1) protein is an important signal transduction adapter for extracellular signal transduction from insulin‐like…”
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FOXD3, frequently methylated in colorectal cancer, acts as a tumor suppressor and induces tumor cell apoptosis under ER stress via p53 by Xu, Ming, Zhu, Jing, Liu, Shuiping, Wang, Chan, Shi, Qinglan, Kuang, Yeye, Fang, Xiao, Hu, Xiaotong

“…Abstract Forkhead box D3 (FOXD3), an important member of the forkhead box transcription factor family, has many biological functions. However, the role and…”
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Progress of research on γδ T cells in colorectal cancer (Review) by Pan, Lijuan, Zhou, Yiru, Kuang, Yeye, Wang, Chan, Wang, Weimin, Hu, Xiaotong, Chen, Xiabin

“…Colorectal cancer (CRC) ranks as the third most prevalent malignancy and second leading cause of cancer‑related fatalities worldwide. Immunotherapy alone or in…”
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Impact of KRAS mutation on the tumor microenvironment in colorectal cancer by Zhou, Yiru, Kuang, Yeye, Wang, Chan, Yu, Yijian, Pan, Lijuan, Hu, Xiaotong

“…Kirsten rat sarcoma viral oncogene homolog (KRAS) is an oncogene implicated in the pathophysiology of many cancers. Increasing evidence shows that KRAS…”
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A novel methylated cation channel TRPM4 inhibited colorectal cancer metastasis through Ca2+/Calpain-mediated proteolysis of FAK and suppression of PI3K/Akt/mTOR signaling pathway by Wang, Chan, Chen, Jiaxin, Kuang, Yeye, Cheng, Xiaoqing, Deng, Min, Jiang, Zhinong, Hu, Xiaotong

“…Colorectal cancer (CRC) is an aggressive malignancy with poor prognosis. It is imperative to elucidate the potential molecular mechanisms that regulate CRC…”
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BCLB, methylated in hepatocellular carcinoma, is a starvation stress sensor that induces apoptosis and autophagy through the AMPK-mTOR signaling cascade by Liu, Xiaolong, Hu, Xiaotong, Kuang, Yeye, Yan, Peijian, Li, Lili, Li, Chen, Tao, Qian, Cai, Xiujun

“…Abstract Epigenetic disruption of tumor suppressor genes (TSGs), particularly DNA methylation, plays a key role in hepatocellular carcinoma (HCC) pathogenesis…”
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Diverse Ras-related GTPase DIRAS2, downregulated by PSMD2 in a proteasome-mediated way, inhibits colorectal cancer proliferation by blocking NF-κB signaling by Ying, Ke, Wang, Chan, Liu, Shuiping, Kuang, Yeye, Tao, Qian, Hu, Xiaotong

“…Colorectal cancer (CRC) is the most common gastrointestinal cancer, with a high mortality rate but limited therapeutic targets. DIRAS family GTPase 2 ( ) is a…”
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A novel methylated cation channel TRPM4 inhibited colorectal cancer metastasis through Ca 2+ /Calpain-mediated proteolysis of FAK and suppression of PI3K/Akt/mTOR signaling pathway by Wang, Chan, Chen, Jiaxin, Kuang, Yeye, Cheng, Xiaoqing, Deng, Min, Jiang, Zhinong, Hu, Xiaotong

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Downregulation of ZNF365 by methylation predicts poor prognosis in patients with colorectal cancer by decreasing phospho‑p53 (Ser15) expression by Wang, Chan, Liu, Shuiping, Kuang, Yeye, Hu, Xiaotong, Fang, Xiao

“…ZNF365 is a transcription factor that plays important roles in different types of cancer, such as colorectal cancer, breast cancer and hepatocellular…”
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The developmental regulator HAND1 inhibits gastric carcinogenesis through enhancing ER stress apoptosis via targeting CHOP and BAK which is augmented by cisplatin by Kuang, Yeye, He, Zhanglian, Li, Lili, Wang, Chan, Cheng, Xiaoqing, Shi, Qinglan, Fu, Guoxiang, Ying, Jianming, Tao, Qian, Hu, Xiaotong

“…Epigenetic disruption of tumor suppressor genes, particularly aberrant CpG methylation, plays a crucial role in gastric cancer (GC) pathogenesis. Through CpG…”
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A novel RON splice variant lacking exon 2 activates the PI3K/AKT pathway via PTEN phosphorylation in colorectal carcinoma cells by Ling, Yu, Kuang, Yeye, Chen, Lin-Lin, Lao, Wei-Feng, Zhu, Yao-Ru, Wang, Le-Qi, Wang, Da

“…Abnormal expression of the Recepteur d'Origine Nantais (RON) receptor tyrosine kinase is accompanied by the generation of multiple splice or truncated…”
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Epigenomic and Functional Characterization of Junctophilin 3 (JPH3) as a Novel Tumor Suppressor Being Frequently Inactivated by Promoter CpG Methylation in Digestive Cancers by Hu, Xiaotong, Kuang, Yeye, Li, Lili, Tang, Haimei, Shi, Qinglan, Shu, Xingsheng, Zhang, Yanjiao, Chan, Francis Kl, Tao, Qian, He, Chao

“…Junctophilin (JPH) proteins stabilize junctional membrane complexes between plasma membrane and endoplasmic reticulum, also implicated in some human diseases…”
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Expression of fibulin-1 predicted good prognosis in patients with colorectal cancer by Zhu, Jing, Chen, Rui, Mo, Lijuan, Tang, Haimei, Kuang, Yeye, Fei, Weiqiang, He, Chao, Hu, Xiaotong

“…Fibulin-1, a multi-functional extracellular matrix protein, has been demonstrated to be involved in many kinds of cancer, while its function in colorectal…”
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