Interactions between poloxamer, PEOx-PPOy-PEOx, and non-ionic surfactant, sucrose monolaurate: A study on potential allergenic effect using model phospholipid membrane

Sugar-based surfactants are involved in skin related allergy cases in the past decade. Skin irritation starts with the interaction of the surfactant with the skin lipids leading to lipid emulsification and eventual barrier damage. Polymers or co-surfactants can be used to mitigate the allergenic eff...

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Published in:	Colloids and surfaces, B, Biointerfaces Vol. 209; no. Pt 1; p. 112153
Main Authors:	Kwek, Jin W., Chakraborty, S., Kuan, Kai C., Yeo, Wen C., Yin, H., Liu, Connie K., Guo, L., Zidar, J., Li, C., Lim, Freda C.H.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-01-2022
Subjects:	Allergens Disruption DPD Lipid bilayer Phospholipids Poloxamer Quartz crystal microbalance Scattering, Small Angle Sucrose - analogs & derivatives Sugar surfactants Surface-Active Agents X-Ray Diffraction Lipid bilayer Sugar surfactants DPD Quartz crystal microbalance Disruption Poloxamer
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Summary:	Sugar-based surfactants are involved in skin related allergy cases in the past decade. Skin irritation starts with the interaction of the surfactant with the skin lipids leading to lipid emulsification and eventual barrier damage. Polymers or co-surfactants can be used to mitigate the allergenic effect but the mechanism of formulation mildness on skin remains unclear. We have used the quartz crystal microbalance (QCM) together with dissipative particle dynamics (DPD) simulation, small angle x-ray scattering (SAXS) as well as cell viability tests to decipher the interactions between poloxamers and sucrose monolaurate (SML), and how these interactions could prevent the disruption of a model supported phospholipid bilayer (SLB). Poloxamer addition to the SML solution can delay or totally prevent the disruption of the SLB depending on poloxamer type and concentration. Poloxamer P407 (Pluronic® F127) delays the onset of disruption while poloxamer P188 (Pluronic® F68) does not preserve the bilayer integrity even at high concentration of up to 15% w/w. Preservation of the SLB is likely due to the differences in the aggregates formation between SML-F127 and SML-F68 mixtures with corresponding retarded motion of SML micelles through the SML-F127 polymer matrix that improved cell viability. [Display omitted] •Poloxamers in skin care formulation can impart mildness.•Poloxamer P407 can form a gel-like mesh structure at high concentration.•Mesh structure slows down the micelles’ diffusion in the formulation.•Hence, micelles are delayed from interacting with skin lipids.•Study has implications for skin mildness formulation design strategy.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0927-7765 1873-4367
DOI:	10.1016/j.colsurfb.2021.112153