Search Results - "Kuan, Isabelle H.S."

The influence of flip‐flop in population pharmacokinetic analyses by Kuan, Isabelle H. S., Wright, Daniel F. B., Duffull, Stephen B.

“…The two permutations using a CL, V, ka and k, V, ka parameterization are shown in Table 1, where CL is clearance and V is volume of distribution and k and ka…”
Get full text

The Association between Metformin Therapy and Lactic Acidosis by Kuan, Isabelle H. S., Savage, Ruth L., Duffull, Stephen B., Walker, Robert J., Wright, Daniel F. B.

“…Introduction and Objectives There is increasing evidence to suggest that therapeutic doses of metformin are unlikely to cause lactic acidosis. The aims of this…”
Get full text

Understanding the association between metformin plasma concentrations and lactate by Kuan, Isabelle H.S., Wright, Daniel F.B., Duffull, Stephen B., Zhu, Xiao

Get full text

Does the intact nephron hypothesis provide a reasonable model for metformin dosing in chronic kidney disease? by Pradhan, Sudeep, Duffull, Stephen B., Wilson, Luke C., Kuan, Isabelle H. S., Walker, Robert J., Putt, Tracey L., Schollum, John B. W., Wright, Daniel F. B.

“…This research explored the intact nephron hypothesis (INH) as a model for metformin dosing in patients with chronic kidney disease (CKD). The INH assumes that…”
Get full text

Metformin doses to ensure efficacy and safety in patients with reduced kidney function by Kuan, Isabelle H S, Wilson, Luke C, Leishman, Jed C, Cosgrove, Samuel, Walker, Robert J, Putt, Tracey L, Schollum, John B W, Wright, Daniel F B

“…We aimed to develop a metformin dosing strategy to optimise efficacy and safety in patients with reduced kidney function. Metformin data from two studies…”
Get full text

The pharmacokinetics of metformin in patients receiving intermittent haemodialysis by Sinnappah, Klarissa A., Kuan, Isabelle H.S., Thynne, Tilenka R.J., Doogue, Matthew P., Wright, Daniel F.B.

“…The aims of this study were to characterise the population pharmacokinetics of metformin in patients receiving haemodialysis, and to determine the doses that…”
Get full text