Search Results - "Kuan, C T"

Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation by Wheeler, S E, Suzuki, S, Thomas, S M, Sen, M, Leeman-Neill, R J, Chiosea, S I, Kuan, C-T, Bigner, D D, Gooding, W E, Lai, S Y, Grandis, J R

“…Epidermal growth factor receptor (EGFR) is frequently overexpressed in head and neck squamous cell carcinoma (HNSCC) where aberrant signaling downstream of…”
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EGF mutant receptor vIII as a molecular target in cancer therapy by Kuan, C T, Wikstrand, C J, Bigner, D D

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Regional Treatment of Epidermal Growth Factor Receptor vIII-expressing Neoplastic Meningitis with a Single-Chain Immunotoxin, MR-1 by ARCHER, G. E, SAMPSON, J. H, LORIMER, I. A. J, MCLENDON, R. E, KUAN, C.-T, FRIEDMAN, A. H, FRIEDMAN, H. S, PASTAN, I. H, BIGNER, D. D

“…The incidence of neoplastic meningitis is on the rise. Neoplastic meningitis can result from a direct seeding of the neuraxis by primary brain tumors or by…”
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Recombinant heregulin-Pseudomonas exotoxin fusion proteins: interactions with the heregulin receptors and antitumor activity in vivo by DAJUN YANG, KUAN, C.-T, PAYNE, J, KIHARA, A, MURRAY, A, WANG, L.-M, ALIMANDI, M, PIERCE, J. H, PASTAN, I, LIPPMAN, M. E

“…Growth factor receptors provide unique opportunities for development of targeted anticancer therapy. Members of the type I receptor tyrosine kinase family,…”
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Improved antitumor activity of a recombinant anti-Lewis(y) immunotoxin not requiring proteolytic activation by Kuan, C T, Pastan, I

“…B1(dsFv)-PE33 is a recombinant immunotoxin composed of a mutant form of Pseudomonas exotoxin (PE) that does not need proteolytic activation and a…”
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Further evidence that transposition of Tn5 in Escherichia coli is strongly enhanced by constitutively activated RecA proteins by Kuan, C T, Tessman, I

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Pseudomonas exotoxin A mutants. Replacement of surface exposed residues in domain II with cysteine residues that can be modified with polyethylene glycol in a site-specific manner by CHIEN-TSUN KUAN, QING-CHENG WANG, PASTAN, I

“…Pseudomonas exotoxin A (PE) is a three-domain protein in which domain Ia is involved in recognition of receptors on eukaryotic target cells, domain II promotes…”
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LexA protein of Escherichia coli represses expression of the Tn5 transposase gene by Kuan, C T, Tessman, I

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Excision and Transposition of Tn5 as an SOS Activity in Escherichia coli by Kuan, C. T, Liu, S. K, Tessman, I

“…Excision and transposition of the Tn5 element in Escherichia coli ordinarily appear to occur by recA-independent mechanisms. However, recA(Prtc) genes, which…”
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Expression of recombinant anticoagulant hirudin in the differentiated cultures of the porcine mammary epithelial cell line SI-PMEC by Sun, Y.L., Chou, Y.C., Kuan, T.C., Tu, C.F., Lin, C.S.

“…To express recombinant proteins in the spontaneously immortalized porcine mammary epithelial cell line (SI-PMEC) currently established in our laboratory, a…”
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Phase I Trial Results of Iodine-131–Labeled Antitenascin Monoclonal Antibody 81C6 Treatment of Patients With Newly Diagnosed Malignant Gliomas by COKGOR, Ilkcan, AKABANI, Gamal, PEGRAM, Charles N, WIKSTRAND, Carol J, SHAFMAN, Timothy D, HERNDON, James E, PROVENZALE, James M, ZALUTSKY, Michael R, BIGNER, Darell D, KUAN, Chien-Tsun, FRIEDMAN, Henry S, FRIEDMAN, Allan H, COLEMAN, R. Edward, MCLENDON, Roger E, BIGNER, Sandra H, ZHAO, Xiao-Guang, GARCIA-TURNER, Ana M

“…To determine the maximum-tolerated dose (MTD) of iodine-131 ((131)I)-labeled 81C6 antitenascin monoclonal antibody (mAb) administered clinically into…”
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Immunotoxins containing Pseudomonas exotoxin that target LeY damage human endothelial cells in an antibody-specific mode: relevance to vascular leak syndrome by Kuan, C T, Pai, L H, Pastan, I

“…Vascular leak syndrome (VLS) was originally found to be a major dose-limiting toxicity in humans with cancer treated with several immunotoxins (ITs) containing…”
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Increased binding affinity enhances targeting of glioma xenografts by EGFRvIII‐specific scFv by Kuan, Chien‐Tsun, Wikstrand, Carol J., Archer, Gary, Beers, Richard, Pastan, Ira, Zalutsky, Michael R., Bigner, Darell D.

“…Combinatorial variation of CDR3 of VH and VL, followed by phage display, was used to select affinity mutants of the parental anti‐epidermal growth factor…”
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Recognition of glioma stem cells by genetically modified T cells targeting EGFRvIII and development of adoptive cell therapy for glioma by Morgan, Richard A, Johnson, Laura A, Davis, Jeremy L, Zheng, Zhili, Woolard, Kevin D, Reap, Elizabeth A, Feldman, Steven A, Chinnasamy, Nachimuthu, Kuan, Chien-Tsun, Song, Hua, Zhang, Wei, Fine, Howard A, Rosenberg, Steven A

“…No curative treatment exists for glioblastoma, with median survival times of less than 2 years from diagnosis. As an approach to develop immune-based therapies…”
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EGFRvIII as a promising target for antibody-based brain tumor therapy by Kuan, C T, Wikstrand, C J, Bigner, D D

“…Cell surface receptors are attractive candidates for targeted therapy of cancer. Growth factors and their receptors play important roles in the regulation of…”
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Three dimensional optic disc visualisation from stereo images via dual registration and ocular media optical correction by Xu, J, Chutatape, O, Zheng, C, Kuan, P C T

“…Background/aims: The three dimensional (3-D) visualisation of the optic disc in true colour will give essential meaning in clinical application. It is not only…”
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Design of a Novel Small Peptide Targeted against a Tumor-Specific Receptor by Campa, Michael J., Kuan, Chien-Tsun, O'Connor-McCourt, Maureen D., Bigner, Darell D., Patz, Edward F.

“…EGFRvIII is the most common deletion variant of the epidermal growth factor receptor and is found in cancers of the brain, breast, ovary, and lung. The…”
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The changes of matrix metalloproteinase-2 and -9 enzyme activities in the children with ventricular septal defect by Lin, C. S., Cheng, K. S., Kuan, T. C., Chen, M. Y.

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125I-labeled Anti-Epidermal Growth Factor Receptor-vIII Single-Chain Fv Exhibits Specific and High-Level Targeting of Glioma Xenografts by KUAN, C.-T, REIST, C. J, FOULON, C. F, LORIMER, I. A. J, ARCHER, G, PEGRAM, C. N, PASTAN, I, ZALUTSKY, M. R, BIGNER, D. D

“…A single-chain antibody fragment, MR1(scFv), with specific binding to epidermal growth factor receptor-vIII (EGFRvIII), was produced, radiolabeled, and…”
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Recombinant Immunotoxin Containing a Disulfide-Stabilized Fv Directed at erbB2 That Does Not Require Proteolytic Activation by Kuan, Chien-Tsun, Pastan, Ira

“…PE35/e23(dsFv)KDEL is a recombinant immunotoxin composed of a recombinant form of Pseudomonas exotoxin that does not need proteolytic activation and a…”
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