Search Results - "Kübler, Eric"

Systematic Meta-Analysis Identifies Co-Expressed Kinases and GPCRs in Ovarian Cancer Tissues Revealing a Potential for Targeted Kinase Inhibitor Delivery by Albrecht, Hugo, Kübler, Eric

“…The use of many anticancer drugs is problematic due to severe adverse effects. While the recent clinical launch of several kinase inhibitors led to tremendous…”
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Development of a DNA-based Assay to Detect and Quantify Tropane Alkaloids Producing Thornapple Contaminations in Processed Food by Weston, Anna, Brodmann, Peter, Widmer, Maximilian, Bartel, Julian, Kübler, Eric

“…Contaminates such as pesticides, toxic molecules of natural origin, genetically modified organisms and others can occur in processed food, especially if the…”
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Using GPCRs as Molecular Beacons to Target Ovarian Cancer with Nanomedicines by Khetan, Riya, Dharmayanti, Cintya, Gillam, Todd A, Kübler, Eric, Klingler-Hoffmann, Manuela, Ricciardelli, Carmela, Oehler, Martin K, Blencowe, Anton, Garg, Sanjay, Albrecht, Hugo

“…The five-year survival rate for women with ovarian cancer is very poor despite radical cytoreductive surgery and chemotherapy. Although most patients initially…”
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Development of a Unique Rapid Test to Detect Anti-bodies Directed Against an Extended RBD of SARS-CoV-2 Spike Protein by Brosi, Larissa, Kübler, Eric, Weston, Anna, Romann, Patrick, Panikulam, Sherin, Dirscherl, Lorin, Gerspach, Michael, Giegelmann, Cedric, Dolce, Daniele, Überschlag, Marie-Eve, Melone, Anna, Bantleon, Frank I, Villiger, Thomas K, Gerhold, Christian-B

“…Serological testing for antibodies directed against SARS-CoV-2 in patients may serve as a diagnostic tool to verify a previous infection and as surrogate for…”
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Yeast-based assays for screening 11β-HSD1 inhibitors by Vanella, Rosario, Callari, Roberta, Weston, Anna, Heider, Harald, Schwab, Markus S, Kübler, Eric

“…Intracellular metabolism of glucocorticoid hormones plays an important role in the pathogenesis of metabolic syndrome and regulates, among many physiological…”
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Diagnosis of prion diseases by Kübler, Eric, Oesch, Bruno, Raeber, Alex J

“…Prion diseases are usually diagnosed clinically and confirmed by post-mortem histopathological examination of brain tissue. The only reliable molecular marker…”
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Oligomeric Structure of Caveolin: Implications for Caveolae Membrane Organization by Sargiacomo, Massimo, Scherer, Philipp E., Tang, ZhaoLan, Kubler, Eric, Song, Kenneth S., Sanders, Mithcell C., Lisanti, Michael P.

“…A 22-kDa protein, caveolin, is localized to the cytoplasmic surface of plasma membrane specializations called caveolae. We have proposed that caveolin may…”
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Large set data mining reveals overexpressed GPCRs in prostate and breast cancer: potential for active targeting with engineered anti-cancer nanomedicines by Kübler, Eric, Albrecht, Hugo

“…Over 800 G-protein-coupled receptors (GPCRs) are encoded by the human genome and many are overexpressed in tumors. GPCRs are triggered by ligand molecules…”
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Crosstalk between the Ras2p-controlled mitogen-activated protein kinase and cAMP pathways during invasive growth of Saccharomyces cerevisiae by Mösch, H U, Kübler, E, Krappmann, S, Fink, G R, Braus, G H

“…The two highly conserved RAS genes of the budding yeast Saccharomyces cerevisiae are redundant for viability. Here we show that haploid invasive growth…”
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Development of an event-specific assay for the qualitative and quantitative detection of the genetically modified flax CDC Triffid (FP967) by Vanella, Rosario, Weston, Anna, Brodmann, Peter, Kübler, Eric

“…The genetically modified flax, event FP967, with tolerance to sulfonylurea herbicides, is one of the commercial genetically modified events approved in Canada…”
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Development of a Unique Rapid Test to Detect Anti-bodies Directed Against an Extended RBD of SARS-CoV-2 Spike Protein: FH-HES Universities of Applied Sciences by Brosi, Larissa, Villiger, Thomas K., Bantleon, Frank I., Melone, Anna, Überschlag, Marie-Eve, Dolce, Daniele, Giegelmann, Cedric, Gerspach, Michael, Dirscherl, Lorin, Panikulam, Sherin, Romann, Patrick, Weston, Anna, Kübler, Eric, Gerhold, Christian-B.

“…Serological testing for antibodies directed against SARS-CoV-2 in patients may serve as a diagnostic tool to verify a previous infection and as surrogate for…”
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Identification of Triton X-100 Insoluble Membrane Domains in the Yeast Saccharomyces cerevisiae by Kübler, Eric, Dohlman, Henrik G., Lisanti, Michael P.

“…Low density Triton X-100 insoluble (LDTI) membrane domains are found in most mammalian cell types. Previous biochemical and immunolocalization studies have…”
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Actin and fimbrin are required for the internalization step of endocytosis in yeast by Kubler, E, Riezman, H

“…In Saccharomyces cerevisiae, alpha-factor is internalized by receptor-mediated endocytosis and transported via vesicular intermediates to the vacuole where the…”
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Fixation of cells for analysis by laser microdissection--comparative studies in forensic trace material by Fischer, Elisabeth J, Laberke, Patrick J, Kübler, Eric, Balitzki, Beate

“…This paper is focused on the preparation of samples for laser microdissection (LM) in forensic casework. In forensic genetics, it is essential to preserve and…”
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Gpa2p, a G-protein α-Subunit, Regulates Growth and Pseudohyphal Development in Saccharomyces cerevisiae via a cAMP-dependent Mechanism by Kübler, Eric, Mösch, Hans-Ulrich, Rupp, Steffen, Lisanti, Michael P.

“…The small GTP-binding protein Ras and heterotrimeric G-proteins are key regulators of growth and development in eukaryotic cells. In mammalian cells, Ras…”
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Recovery of blood traces with scenesafe FAST tape by Keller, Eva, Looser, Markus, Bieri, Hans-Peter, Kübler, Eric, Balitzki, Beate

“…For complete and conclusive DNA profiling a sufficient amount of DNA must be available. For that, biological traces are recovered from crime scenes using…”
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Unconventional P-35S sequence identified in genetically modified maize by Al-Hmoud, Nisreen, Al-Husseini, Nawar, Ibrahim-Alobaide, Mohammed A, Kübler, Eric, Farfoura, Mahmoud, Alobydi, Hytham, Al-Rousan, Hiyam

“…The Cauliflower Mosaic Virus 35S promoter sequence, CaMV P-35S, is one of several commonly used genetic targets to detect genetically modified maize and is…”
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Diagnosis of prion diseases: Prions for physicians by KÜBLER, Eric, OESCH, Bruno, RAEBER, Alex J

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Validation of a luminescence immunoassay for the detection of PrP(Sc) in brain homogenate by Biffiger, Karin, Zwald, Daniel, Kaufmann, Lukas, Briner, Alexandra, Nayki, Inci, Pürro, Mario, Bottcher, Sigrid, Struckmeyer, Thomas, Schaller, Olivier, Meyer, Rudolf, Fatzer, Rosemarie, Zurbriggen, Andres, Stack, Mick, Moser, Markus, Oesch, Bruno, Kübler, Eric

“…A luminescence immunoassay (LIA) was developed for the diagnosis of bovine spongiform encephalopathy (BSE) in brain tissue using two different monoclonal…”
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Identification of Triton X-100 insoluble membrane domains in the yeast Saccharomyces cerevisiae: lipid requirements for targeting of heterotrimeric G-protein subunits by Kubler, E. (The Whitehead Institute for Biomedical Research, Cambridge, MA.), Dohlman, H.G, Lisanti, M.P

“…Low density Triton X-100 insoluble (LDTI) membrane domains are found in most mammalian cell types. Previous biochemical and immunolocalization studies have…”
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