Search Results - "Ku, Sherman"

Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ESCs and iPSCs during Reprogramming and Time in Culture by Laurent, Louise C., Ulitsky, Igor, Slavin, Ileana, Tran, Ha, Schork, Andrew, Morey, Robert, Lynch, Candace, Harness, Julie V., Lee, Sunray, Barrero, Maria J., Ku, Sherman, Martynova, Marina, Semechkin, Ruslan, Galat, Vasiliy, Gottesfeld, Joel, Belmonte, Juan Carlos Izpisua, Murry, Chuck, Keirstead, Hans S., Park, Hyun-Sook, Schmidt, Uli, Laslett, Andrew L., Muller, Franz-Josef, Nievergelt, Caroline M., Shamir, Ron, Loring, Jeanne F.

“…Genomic stability is critical for the clinical use of human embryonic and induced pluripotent stem cells. We performed high-resolution SNP (single-nucleotide…”
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Epigenetic therapy for Friedreich ataxia by Soragni, Elisabetta, Miao, Wenyan, Iudicello, Marco, Jacoby, David, De Mercanti, Stefania, Clerico, Marinella, Longo, Filomena, Piga, Antonio, Ku, Sherman, Campau, Erica, Du, Jintang, Penalver, Pablo, Rai, Myriam, Madara, Joseph C., Nazor, Kristopher, O'Connor, Melinda, Maximov, Anton, Loring, Jeanne F., Pandolfo, Massimo, Durelli, Luca, Gottesfeld, Joel M., Rusche, James R.

“…Objective To investigate whether a histone deacetylase inhibitor (HDACi) would be effective in an in vitro model for the neurodegenerative disease Friedreich…”
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Development of recombinase-based targeted integration systems for production of exogenous proteins using transposon-mediated landing pads by Reese, Nina B., Ku, Sherman

“…[Display omitted] •PhiC31 and Cre recombinases enable various forms of genomic targeted integration.•Landing pads designed with eGFP enable facile sort…”
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Role of Mismatch Repair Enzymes in GAA·TTC Triplet-repeat Expansion in Friedreich Ataxia Induced Pluripotent Stem Cells by Du, Jintang, Campau, Erica, Soragni, Elisabetta, Ku, Sherman, Puckett, James W., Dervan, Peter B., Gottesfeld, Joel M.

“…The genetic mutation in Friedreich ataxia (FRDA) is a hyperexpansion of the triplet-repeat sequence GAA·TTC within the first intron of the FXN gene. Although…”
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Friedreich's Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA⋅TTC Triplet Repeat Instability by Ku, Sherman, Soragni, Elisabetta, Campau, Erica, Thomas, Elizabeth A., Altun, Gulsah, Laurent, Louise C., Loring, Jeanne F., Napierala, Marek, Gottesfeld, Joel M.

“…The inherited neurodegenerative disease Friedreich's ataxia (FRDA) is caused by GAA⋅TTC triplet repeat hyperexpansions within the first intron of the FXN gene,…”
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A Two-Hit Mechanism for Pre-Mitotic Arrest of Cancer Cell Proliferation by a Polyamide-Alkylator Conjugate by Alvarez, David, Chou, C. James, Latella, Lucia, Zeitlin, Samantha G., Ku, Sherman, Puri, Pier Lorenzo, Dervan, Peter B., Gottesfeld, Joel M.

“…A polyamide-chlorambucil conjugate (1R-Chl) arrests a wide range of human cancer cell lines at the G2/M phase of the cell cycle and down-regulates histone H4c…”
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A Single-Cell Roadmap of Lineage Bifurcation in Human ESC Models of Embryonic Brain Development by Yao, Zizhen, Mich, John K., Ku, Sherman, Menon, Vilas, Krostag, Anne-Rachel, Martinez, Refugio A., Furchtgott, Leon, Mulholland, Heather, Bort, Susan, Fuqua, Margaret A., Gregor, Ben W., Hodge, Rebecca D., Jayabalu, Anu, May, Ryan C., Melton, Samuel, Nelson, Angelique M., Ngo, N. Kiet, Shapovalova, Nadiya V., Shehata, Soraya I., Smith, Michael W., Tait, Leah J., Thompson, Carol L., Thomsen, Elliot R., Ye, Chaoyang, Glass, Ian A., Kaykas, Ajamete, Yao, Shuyuan, Phillips, John W., Grimley, Joshua S., Levi, Boaz P., Wang, Yanling, Ramanathan, Sharad

“…During human brain development, multiple signaling pathways generate diverse cell types with varied regional identities. Here, we integrate single-cell RNA…”
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Cyclic tetrapeptide HDAC inhibitors as potential therapeutics for spinal muscular atrophy: Screening with iPSC-derived neuronal cells by Lai, Jiun-I, Leman, Luke J., Ku, Sherman, Vickers, Chris J., Olsen, Christian A., Montero, Ana, Ghadiri, M. Reza, Gottesfeld, Joel M.

“…[Display omitted] Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder that is caused by inactivating mutations in the Survival of…”
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miRNA sensitivity to Drosha levels correlates with pre-miRNA secondary structure by Sperber, Henrik, Beem, Alan, Shannon, Sandra, Jones, Ross, Banik, Pratyusha, Chen, Yu, Ku, Sherman, Varani, Gabriele, Yao, Shuyuan, Ruohola-Baker, Hannele

“…microRNAs (miRNAs) are crucial for cellular development and homeostasis. In order to better understand regulation of miRNA biosynthesis, we studied cleavage of…”
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Epigenetic therapy for F riedreich ataxia by Soragni, Elisabetta, Miao, Wenyan, Iudicello, Marco, Jacoby, David, De Mercanti, Stefania, Clerico, Marinella, Longo, Filomena, Piga, Antonio, Ku, Sherman, Campau, Erica, Du, Jintang, Penalver, Pablo, Rai, Myriam, Madara, Joseph C., Nazor, Kristopher, O'Connor, Melinda, Maximov, Anton, Loring, Jeanne F., Pandolfo, Massimo, Durelli, Luca, Gottesfeld, Joel M., Rusche, James R.

“…Objective To investigate whether a histone deacetylase inhibitor (HDACi) would be effective in an in vitro model for the neurodegenerative disease Friedreich…”
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Selecting and isolating colonies of human induced pluripotent stem cells reprogrammed from adult fibroblasts by Polak, Urszula, Hirsch, Calley, Ku, Sherman, Gottesfeld, Joel, Dent, Sharon Y R, Napierala, Marek

“…Herein we present a protocol of reprogramming human adult fibroblasts into human induced pluripotent stem cells (hiPSC) using retroviral vectors encoding…”
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Selecting and Isolating Colonies of Human Induced Pluripotent Stem Cells Reprogrammed from Adult Fibroblasts by Polak, Urszula, Hirsch, Calley, Ku, Sherman, Gottesfeld, Joel, Dent, Sharon Y.R., Napierala, Marek

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Modelling Friedreich's Ataxia Using Human Induced Pluripotent Stem Cells by Ku, Sherman

“…Friedreich’s ataxia (FRDA) is a genetic disorder characterized by a GAA•TTC triplet repeat expansion in the first intron of the gene frataxin. In unaffected…”
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Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ES and iPS Cells during Reprogramming and Time in Culture by Laurent, Louise C., Ulitsky, Igor, Slavin, Ileana, Tran, Ha, Schork, Andrew, Morey, Robert, Lynch, Candace, Harness, Julie V., Lee, Sunray, Barrero, Maria J., Ku, Sherman, Martynova, Marina, Semechkin, Ruslan, Galat, Vasiliy, Gottesfeld, Joel, Belmonte, Juan Carlos Izpisua, Murry, Chuck, Keirstead, Hans S., Park, Hyun-Sook, Schmidt, Uli, Laslett, Andrew L., Muller, Franz-Josef, Nievergelt, Caroline M., Shamir, Ron, Loring, Jeanne F.

“…Genomic stability is critical for the clinical use of human embryonic and induced pluripotent stem cells. We performed high resolution SNP (single nucleotide…”
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Modelling Friedreich's Ataxia Using Human Induced Pluripotent Stem Cells by Ku, Sherman

“…Friedreich's ataxia (FRDA) is a genetic disorder characterized by a GAA*TTC triplet repeat expansion in the first intron of the gene frataxin. In unaffected…”
Get full text

Friedreich's Ataxia Induced Pluripotent Stem Cells Model lntergenerational GAA · TTC Triplet Repeat Instability by KU, Sherman, SORAGNI, Elisabetta, CAMPAU, Erica, THOMAS, Elizabeth A, ALTUN, Gulsah, LAURENT, Louise C, LORING, Jeanne F, NAPIERALA, Marek, GOTTESFELD, Joel M

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