Search Results - "Ku, E C"

Effect of diclofenac sodium on the arachidonic acid cascade by Ku, E C, Lee, W, Kothari, H V, Scholer, D W

“…The anti-inflammatory activity of nonsteroidal anti-inflammatory drugs is primarily attributed to inhibition of distinct steps in the arachidonic acid cascade,…”
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CGS 12970: a novel, long acting thromboxane synthetase inhibitor by Ambler, John, Butler, Keith D., Ku, Edmond C., Maguire, Eric D., Smith, James R., Wallis, Robert B.

“…1 CGS 12970 is a potent selective inhibitor of human platelet thromboxane synthestase in vitro (IC50 = 12 nM). It is four orders of magnitude less potent as an…”
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Regulation of Fatty Acid Biosynthesis by Intermediates of the Cholesterol Biosynthetic Pathway by Ku, Edmond C.

“…The biosynthesis of cholesterol and fatty acid (FA) proceeds by independent pathways. Information is lacking on potential interaction that could provide…”
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Antiinflammatory agents and inhibition of ocular prostaglandin synthetase by Ku, E C, Signor, C, Eakins, E

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CGS 15435A, a thromboxane synthetase inhibitor with an extended duration of action: a comparison with dazoxiben by Olson, R W, Cohen, D S, Ku, E C, Kimble, E F, Renfroe, H B, Smith, 3rd, E F

“…CGS 15435A, a novel thromboxane (Tx) synthetase inhibitor (5-chloro-1-methyl-2-(3-pyridyl)-3-indolhexanoic acid HCl), had a selectivity for Tx synthetase…”
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Pharmacology of diclofenac sodium by Scholer, D W, Ku, E C, Boettcher, I, Schweizer, A

“…Diclofenac sodium is the active ingredient in Voltaren, a nonsteroidal anti-inflammatory drug designed by selection of appropriate physicochemical and steric…”
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The effect of non-specific nutrients on absorption and catabolism of essential amino acids by a bacterium by Ku, E C, King, K W, Engel, R W

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Characterization of CGS 8515 as a selective 5-lipoxygenase (5-LO) inhibitor by Ku, E C, Raychaudhuri, A, Ghai, G, Kimble, E F, Lee, W H, Colombo, C, Dotson, R, White, D, Oglesby, T D, Wasley, J W

“…1. CGS 8515 selectively inhibited 5-LO (IC50 = 0.1 microM) with negligible effect on CO, 12-LO, 15-LO and TxS at concentrations up to 100 microM. 2. CGS 8515…”
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Effects of diclofenac sodium on arachidonic acid metabolism by Ku, E C, Kothari, H, Lee, W, Kimble, E F, Liauw, L H

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The effects of diclofenac sodium on arachidonic acid metabolism by Ku, E C, Lee, W, Kothari, H V, Kimble, E F, Liauw, L, Tjan, J

“…Evidence has been presented that inhibition by diclofenac sodium of the production of leukotrienes by cells participating in the inflammatory process is due to…”
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Nutritional factors influencing the efficiency of utilization of essential amino acids: level of nonessential nitrogen by Ku, E C, King, K W, Engel, R W

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An alternate mechanism for regulation of leukotriene production in leukocytes: studies with an anti-inflammatory drug, sodium diclofenac by Kothari, H V, Lee, W H, Ku, E C

“…Sodium diclofenac, a potent cyclooxygenase inhibitor, was recently shown to inhibit arachidonic acid conversion to leukotriene products in human leukocytes…”
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Diclofenac sodium (GP 45840, Voltaren), a potent inhibitor of prostaglandin synthetase by Ku, E C, Wasvary, J M, Cash, W D

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Pharmacology of diclofenac sodium (Voltaren) by Scholer, D W, Boettcher, I, Ku, E C, Schweizer, A

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Characterization of CGS 8515 as a selective 5-lipoxygenase inhibitor using in vitro and in vivo models by Ku, E C, Raychaudhuri, A, Ghai, G, Kimble, E F, Lee, W H, Colombo, C, Dotson, R, Oglesby, T D, Wasley, J W

“…CGS 8515 inhibited 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 synthesis in guinea pig leukocytes (IC50 = 0.1 microM). The compound did not…”
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Inhibition of prostaglandin synthase by pirprofen. Studies with sheep seminal vesicle enzyme by Ku, E C, Wasvary, J M

“…1. Pirprofen, racemic 2-[3-chloro-4(3-pyrrolinyl) phenyl] propionic acid, was evaluated for its ability to inhibit the conversion of arachidonic acid into…”
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Characterization of imidazo[1,5-a]pyridine-5-hexanoic acid (CGS 13080) as a selective thromboxane synthetase inhibitor using in vitro and in vivo biochemical models by Ku, E C, McPherson, S E, Signor, C, Chertock, H, Cash, W D

“…CGS 13080 inhibited cell-free thromboxane synthetase with an IC50 of 3 nM. It was at least five orders of magnitude less potent toward other key enzymes…”
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