Search Results - "Ku, Colton K."

Copper-Catalyzed Three-Component Aminofluorination of Alkenes and 1,3-Dienes: Direct Entry to Diverse β‑Fluoroalkylamines by Feng, Guangshou, Ku, Colton K., Zhao, Jiaqi, Wang, Qiu

“…Rapid and efficient access to structurally diverse β-fluoroalkylamines is in high demand, with their wide presence and great importance in medicinal chemistry…”
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High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators by Son, Jung-Ho, Zhu, Jie S, Phuan, Puay-Wah, Cil, Onur, Teuthorn, Andrew P, Ku, Colton K, Lee, Sujin, Verkman, Alan S, Kurth, Mark J

“…We previously identified phenylquinoxalinone CFTRact-J027 (4) as a cystic fibrosis transmembrane conductance regulator (CFTR) activator with an EC50 of ∼200 nM…”
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Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation by Cil, Onur, Phuan, Puay-Wah, Son, Jung-Ho, Zhu, Jie S., Ku, Colton K., Tabib, Niloufar Akhavan, Teuthorn, Andrew P., Ferrera, Loretta, Zachos, Nicholas C., Lin, Ruxian, Galietta, Luis J.V., Donowitz, Mark, Kurth, Mark J., Verkman, Alan S.

“…Constipation is a common condition for which current treatments can have limited efficacy. By high-throughput screening, we recently identified a…”
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Phenylquinoxalinone CFTR activator as potential pro-secretory therapy for constipation by Cil, Onur, Phuan, Puay-Wah, Son, Jung-Ho, Zhu, Jie S, Ku, Colton K, Tabib, Niloufar Akhavan, Teuthorn, Andrew P, Ferrera, Loretta, Zachos, Nicholas C, Lin, Ruxian, Galietta, Luis J.V, Donowitz, Mark, Kurth, Mark J, Verkman, A.S

“…Abstract Constipation is a common condition for which current treatments can have limited efficacy. By high-throughput screening we recently identified a…”
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