Search Results - "Ku, Chen‐Chia"

Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells by Wuputra, Kenly, Ku, Chia-Chen, Wu, Deng-Chyang, Lin, Ying-Chu, Saito, Shigeo, Yokoyama, Kazunari K

“…Human pluripotent embryonic stem cells have two special features: self-renewal and pluripotency. It is important to understand the properties of pluripotent…”
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Redox control in the pathophysiology of influenza virus infection by Chen, Ker-Kong, Minakuchi, Moeko, Wuputra, Kenly, Ku, Chia-Chen, Pan, Jia-Bin, Kuo, Kung-Kai, Lin, Ying-Chu, Saito, Shigeo, Lin, Chang-Shen, Yokoyama, Kazunari K

“…Triggered in response to external and internal ligands in cells and animals, redox homeostasis is transmitted via signal molecules involved in defense redox…”
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Translational models of 3-D organoids and cancer stem cells in gastric cancer research by Wuputra, Kenly, Ku, Chia-Chen, Kato, Kohsuke, Wu, Deng-Chyang, Saito, Shigeo, Yokoyama, Kazunari K

“…Abstract It is postulated as a general concept of cancer stem cells (CSCs) that they can produce cancer cells overtly and repopulate cancer progenitor cells…”
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Reprogramming Antagonizes the Oncogenicity of HOXA13‐Long Noncoding RNA HOTTIP Axis in Gastric Cancer Cells by Wu, Deng‐Chyang, Wang, Sophie S.W., Liu, Chung‐Jung, Wuputra, Kenly, Kato, Kohsuke, Lee, Yen‐Liang, Lin, Ying‐Chu, Tsai, Ming‐Ho, Ku, Chia‐Chen, Lin, Wen‐Hsin, Wang, Shin‐Wei, Kishikawa, Shotaro, Noguchi, Michiya, Wu, Chu‐Chieh, Chen, Yi‐Ting, Chai, Chee‐Yin, Lin, Chen‐Lung Steve, Kuo, Kung‐Kai, Yang, Ya‐Han, Miyoshi, Hiroyuki, Nakamura, Yukio, Saito, Shigeo, Nagata, Kyosuke, Lin, Chang‐Shen, Yokoyama, Kazunari K.

“…Reprogramming of cancer cells into induced pluripotent stem cells (iPSCs) is a compelling idea for inhibiting oncogenesis, especially through modulation of…”
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Independent Signaling of Hepatoma Derived Growth Factor and Tumor Necrosis Factor-Alpha in Human Gastric Cancer Organoids Infected by Helicobacter pylori by Wuputra, Kenly, Ku, Chia-Chen, Pan, Jia-Bin, Liu, Chung-Jung, Kato, Kohsuke, Lin, Ying-Chu, Liu, Yi-Chang, Lin, Chang-Shen, Hsiao, Michael, Tai, Ming-Hong, Chong, Inn-Wen, Hu, Huang-Ming, Kuo, Chao-Hung, Wu, Deng-Chyang, Yokoyama, Kazunari K

“…We prepared three-dimensional (3-D) organoids of human stomach cancers and examined the correlation between the tumorigenicity and cytotoxicity of ( ). In…”
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Heterogeneity of Phase II Enzyme Ligands on Controlling the Progression of Human Gastric Cancer Organoids as Stem Cell Therapy Model by Wu, Deng-Chyang, Ku, Chia-Chen, Pan, Jia-Bin, Wuputra, Kenly, Yang, Ya-Han, Liu, Chung-Jung, Liu, Yi-Chang, Kato, Kohsuke, Saito, Shigeo, Lin, Ying-Chu, Chong, Inn-Wen, Hsiao, Michael, Hu, Huang-Ming, Kuo, Chao-Hung, Kuo, Kung-Kai, Lin, Chang-Shen, Yokoyama, Kazunari K

“…Gastric cancer (GC) organoids are frequently used to examine cell proliferation and death as well as cancer development. Invasion/migration assay,…”
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Positive Feedback Loop of OCT4 and c‐JUN Expedites Cancer Stemness in Liver Cancer by Kuo, Kung‐Kai, Lee, King‐Teh, Chen, Ker‐Kong, Yang, Ya‐Han, Lin, Ying‐Chu, Tsai, Ming‐Ho, Wuputra, Kenly, Lee, Yen‐Liang, Ku, Chia‐Chen, Miyoshi, Hiroyuki, Nakamura, Yukio, Saito, Shigeo, Wu, Chun‐Chieh, Chai, Chee‐Yin, Eckner, Richard, Steve Lin, Chen‐Lung, Wang, Sophie S‐W, Wu, Deng‐Chyang, Lin, Chang‐Shen, Yokoyama, Kazunari K.

“…The network of stemness genes and oncogenes in human patient‐specific reprogrammed cancer stem cells (CSCs) remains elusive, especially in liver cancer…”
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Vulnerability of Antioxidant Drug Therapies on Targeting the Nrf2-Trp53-Jdp2 Axis in Controlling Tumorigenesis by Lin, Ying-Chu, Ku, Chia-Chen, Wuputra, Kenly, Wu, Deng-Chyang, Yokoyama, Kazunari K

“…Control of oxidation/antioxidation homeostasis is important for cellular protective functions, and disruption of the antioxidation balance by exogenous and…”
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How the Strength of Monsoon Winds Shape Forest Dynamics by Ku, Chen-Chia, Chao, Kuo-Jung, Song, Guo-Zhang M., Lin, Huan-Yu, Fan, Su-Wei, Chao, Wei-Chun

“…Monitoring long-term forest dynamics can improve our understanding of how tree species change under varying environmental conditions over time. The Nanjenshan…”
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Generation of Human Stomach Cancer iPSC-Derived Organoids Induced by Helicobacter pylori Infection and Their Application to Gastric Cancer Research by Ku, Chia-Chen, Wuputra, Kenly, Pan, Jia-Bin, Li, Chia-Pei, Liu, Chung-Jung, Liu, Yi-Chang, Saito, Shigeo, Chan, Te-Fu, Lin, Chang-Shen, Wu, Deng-Chyang, Yokoyama, Kazunari K

“…There is considerable cellular diversity in the human stomach, which has helped to clarify cell plasticity in normal development and tumorigenesis. Thus, the…”
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Deletion of Jdp2 enhances Slc7a11 expression in Atoh-1 positive cerebellum granule cell progenitors in vivo by Ku, Chia-Chen, Wuputra, Kenly, Kato, Kohsuke, Pan, Jia-Bin, Li, Chia-Pei, Tsai, Ming-Ho, Noguchi, Michiya, Nakamura, Yukio, Liu, Chung-Jung, Chan, Te-Fu, Hou, Ming-Feng, Wakana, Shigeharu, Wu, Yang-Chang, Lin, Chang-Shen, Wu, Deng-Chyang, Yokoyama, Kazunari K

“…Abstract Background The cerebellum is the sensitive region of the brain to developmental abnormalities related to the effects of oxidative stresses. Abnormal…”
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Dimethyl sulfoxide stimulates the AhR-Jdp2 axis to control ROS accumulation in mouse embryonic fibroblasts by Wuputra, Kenly, Tsai, Ming-Ho, Kato, Kohsuke, Yang, Ya-han, Pan, Jia-Bin, Ku, Chia-Chen, Noguchi, Michiya, Kishikawa, Shotaro, Nakade, Koji, Chen, Hua-Ling, Liu, Chung-Jung, Nakamura, Yukio, Kuo, Kung-Kai, Lin, Ying-Chu, Chan, Te-Fu, Wu, Deng-Chyang, Hou, Ming-Feng, Huang, Shau-Ku, Lin, Chang-Shen, Yokoyama, Kazunari K.

“…The aryl hydrocarbon receptor (AhR) is a ligand-binding protein that responds to environmental aromatic hydrocarbons and stimulates the transcription of…”
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Therapeutic Strategies Targeting Tumor Suppressor Genes in Pancreatic Cancer by Kuo, Kung-Kai, Hsiao, Pi-Jung, Chang, Wen-Tsan, Chuang, Shih-Chang, Yang, Ya-Han, Wuputra, Kenly, Ku, Chia-Chen, Pan, Jia-Bin, Li, Chia-Pei, Kato, Kohsuke, Liu, Chung-Jung, Wu, Deng-Chyang, Yokoyama, Kazunari K

“…The high mortality of pancreatic cancer is attributed to the insidious progression of this disease, which results in a delayed diagnosis and advanced disease…”
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Jdp2-deficient granule cell progenitors in the cerebellum are resistant to ROS-mediated apoptosis through xCT/Slc7a11 activation by Ku, Chia-Chen, Wuputra, Kenly, Kato, Kohsuke, Lin, Wen-Hsin, Pan, Jia-Bin, Tsai, Shih-Chieh, Kuo, Che-Jung, Lee, Kan-Hung, Lee, Yan-Liang, Lin, Ying-Chu, Saito, Shigeo, Noguchi, Michiya, Nakamura, Yukio, Miyoshi, Hiroyuki, Eckner, Richard, Nagata, Kyosuke, Wu, Deng-Chyang, Lin, Chang-Shen, Yokoyama, Kazunari K.

“…The Jun dimerization protein 2 (Jdp2) is expressed predominantly in granule cell progenitors (GCPs) in the cerebellum, as was shown in Jdp2 -promoter-Cre…”
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Biomarkers of Cancer Stem Cells for Experimental Research and Clinical Application by Saito, Shigeo, Ku, Chia-Chen, Wuputra, Kenly, Pan, Jia-Bin, Lin, Chang-Shen, Lin, Ying-Chu, Wu, Deng-Chyang, Yokoyama, Kazunari K

“…The use of biomarkers in cancer diagnosis, therapy, and prognosis has been highly effective over several decades. Studies of biomarkers in cancer patients pre-…”
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Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery by Wuputra, Kenly, Tsai, Ming-Ho, Kato, Kohsuke, Ku, Chia-Chen, Pan, Jia-Bin, Yang, Ya-Han, Saito, Shigeo, Wu, Chun-Chieh, Lin, Ying-Chu, Cheng, Kuang-Hung, Kuo, Kung-Kai, Noguchi, Michiya, Nakamura, Yukio, Yoshioka, Tohru, Wu, Deng-Chyang, Lin, Chang-Shen, Yokoyama, Kazunari K

“…BACKGROUNDCrosstalk between the aryl hydrocarbon receptor (AhR) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling is called the "AhR-Nrf2 gene…”
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Stem Cell Biomarkers and Tumorigenesis in Gastric Cancer by Wuputra, Kenly, Ku, Chia-Chen, Pan, Jia-Bin, Liu, Chung-Jung, Liu, Yi-Chang, Saito, Shigeo, Kato, Kohsuke, Lin, Ying-Chu, Kuo, Kung-Kai, Chan, Te-Fu, Chong, Inn-Wen, Lin, Chang-Shen, Wu, Deng-Chyang, Yokoyama, Kazunari K.

“…Stomach cancer has a high mortality, which is partially caused by an absence of suitable biomarkers to allow detection of the initiation stages of cancer…”
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Bovine induced pluripotent stem cells are more resistant to apoptosis than testicular cells in response to mono-(2-ethylhexyl) phthalate by Lin, Ying-Chu, Kuo, Kung-Kai, Wuputra, Kenly, Lin, Shih-Han, Ku, Chia-Chen, Yang, Ya-Han, Wang, Shin-Wei, Wang, Sheng-Wen, Wu, Deng-Chyang, Wu, Chun-Chien, Chai, Chee-Yin, Lin, Cheng-Lung, Lin, Chang-Shen, Kajitani, Masayuki, Miyoshi, Hiroyuki, Nakamura, Yukio, Hashimoto, Shinichi, Matsushima, Kouji, Jin, Chunyuan, Huang, Shau-Ku, Saito, Shigeo, Yokoyama, Kazunari K

“…Although the androgen receptor (AR) has been implicated in the promotion of apoptosis in testicular cells (TSCs), the molecular pathway underlying AR-mediated…”
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Cancer cell reprogramming to identify the genes competent for generating liver cancer stem cells by Wuputra, Kenly, Lin, Chang-Shen, Tsai, Ming-Ho, Ku, Chia-Chen, Lin, Wen-Hsin, Yang, Ya-Han, Kuo, Kung-Kai, Yokoyama, Kazunari K

“…The cancer stem cell (CSC) hypothesis postulates that cancer originates from the malignant transformation of stem/progenitor cells and is considered to apply…”
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Jun Dimerization Protein 2 Controls Senescence and Differentiation via Regulating Histone Modification by Hasegawa, Hitomi, Huang, Yu-Chang, Wang, Shin-Wei, Ku, Chia-Chen, Lin, Ying-Chu, Chiou, Shyh-Shin, Hou, Ming-Feng, Wu, Deng-Chyang, Tsai, Eing-Mei, Saito, Shigeo, Yamaguchi, Naoto, Yokoyama, Kazunari K.

“…Transcription factor, Jun dimerization protein 2 (JDP2), binds directly to histones and DNAs and then inhibits the p300-mediated acetylation both of core…”
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