Search Results - "Ksiazek, Krzysztof"

Where does cellular senescence belong in the pathophysiology of ovarian cancer? by Książek, Krzysztof

“…Although ovarian cancer is the leading cause of death from gynecological malignancies, there are still some issues that hamper accurate interpretation of the…”
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The peritoneal “soil” for a cancerous “seed”: a comprehensive review of the pathogenesis of intraperitoneal cancer metastases by Mikuła-Pietrasik, Justyna, Uruski, Paweł, Tykarski, Andrzej, Książek, Krzysztof

“…Various types of tumors, particularly those originating from the ovary and gastrointestinal tract, display a strong predilection for the peritoneal cavity as…”
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Mechanisms and significance of therapy-induced and spontaneous senescence of cancer cells by Mikuła-Pietrasik, Justyna, Niklas, Arkadiusz, Uruski, Paweł, Tykarski, Andrzej, Książek, Krzysztof

“…In contrast to the well-recognized replicative and stress-induced premature senescence of normal somatic cells, mechanisms and clinical implications of…”
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Molecular Biology of Ovarian Cancer: From Mechanisms of Intraperitoneal Metastasis to Therapeutic Opportunities by Książek, Krzysztof

“…Ovarian cancer (OC) is one of the most frequent malignancies of the female genital tract, and is still the leading cause of death from gynecological tumors…”
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The functional multipotency of transforming growth factor β signaling at the intersection of senescence and cancer by Mikuła-Pietrasik, Justyna, Rutecki, Szymon, Książek, Krzysztof

“…The transforming growth factor β (TGF-β) family of cytokines comprises a group of proteins, their receptors, and effector molecules that, in a coordinated…”
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Mitochondrial dysfunction is a possible cause of accelerated senescence of mesothelial cells exposed to high glucose by Ksiazek, Krzysztof, Passos, João F., Olijslagers, Sharon, von Zglinicki, Thomas

“…High glucose has been found to accelerate cell senescence in vitro. The exact mechanism of this effect is, however, still poorly understood. In this paper we…”
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Comprehensive review on how platinum- and taxane-based chemotherapy of ovarian cancer affects biology of normal cells by Mikuła-Pietrasik, Justyna, Witucka, Anna, Pakuła, Martyna, Uruski, Paweł, Begier-Krasińska, Beata, Niklas, Arkadiusz, Tykarski, Andrzej, Książek, Krzysztof

“…One of the most neglected aspects of chemotherapy are changes, and possible consequences of these changes, that occur in normal somatic cells. In this review,…”
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Malignant Ascites Promote Adhesion of Ovarian Cancer Cells to Peritoneal Mesothelium and Fibroblasts by Uruski, Paweł, Mikuła-Pietrasik, Justyna, Pakuła, Martyna, Budkiewicz, Sylwia, Drzewiecki, Marcin, Gaiday, Andrey N, Wierzowiecka, Małgorzata, Naumowicz, Eryk, Moszyński, Rafał, Tykarski, Andrzej, Książek, Krzysztof

“…Although malignant ascites (MAs) are known to contribute to various aspects of ovarian cancer progression, knowledge regarding their role in the adhesion of…”
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Alterations of receptors and insulin-like growth factor binding proteins in senescent cells by Matuszewska, Julia, Krawiec, Adrianna, Radziemski, Artur, Uruski, Paweł, Tykarski, Andrzej, Mikuła-Pietrasik, Justyna, Książek, Krzysztof

“…The knowledge about cellular senescence expands dynamically, providing more and more conclusive evidence of its triggers, mechanisms, and consequences…”
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A comprehensive review on mesenchymal stem cell growth and senescence by Ksiazek, Krzysztof

“…In recent years mesenchymal stem cells (MSCs) have generated a great deal of excitement as an attractive alternative to embryonic stem cells (ESCs) in…”
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L-Carnosine Prevents the Pro-cancerogenic Activity of Senescent Peritoneal Mesothelium Towards Ovarian Cancer Cells by Mikuła-Pietrasik, Justyna, Książek, Krzysztof

“…L-Carnosine inhibits senescence of somatic cells and displays anticancer activity. Here we analyzed if L-carnosine (20 mM) retards senescence of human…”
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Investigating diverse photogrammetric techniques in the hazard assessment of historical sites of the Museum of the Coal Basin Area in Będzin, Poland by Świerczyńska, Ewa, Karsznia, Krzysztof, Książek, Krzysztof, Odziemczyk, Waldemar

“…Assessing the condition of historical sites at risk requires an interdisciplinary approach based on combining multiple measurement technologies. Due to the…”
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Mesothelial cell: A multifaceted model of aging by KSIAZEK, Krzysztof

“…Graphical abstract Highlights ► Primary cultures of HPMCs display extremely short replicative lifespan in vitro . ► Young HPMCs are highly vulnerable to…”
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Nontraditional systems in aging research: an update by Mikuła-Pietrasik, Justyna, Pakuła, Martyna, Markowska, Małgorzata, Uruski, Paweł, Szczepaniak-Chicheł, Ludwina, Tykarski, Andrzej, Książek, Krzysztof

“…Research on the evolutionary and mechanistic aspects of aging and longevity has a reductionist nature, as the majority of knowledge originates from experiments…”
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The double-edged sword of long non-coding RNA: The role of human brain-specific BC200 RNA in translational control, neurodegenerative diseases, and cancer by Sosińska, Patrycja, Mikuła-Pietrasik, Justyna, Książek, Krzysztof

“…The complexity of eukaryotic organisms involves the regulation of gene expression through DNA–protein, RNA–DNA, RNA–RNA, and RNA–protein interactions. The role…”
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Primary high-grade serous ovarian cancer cells are sensitive to senescence induced by carboplatin and paclitaxel in vitro by Uruski, Paweł, Sepetowska, Agnieszka, Konieczna, Corinna, Pakuła, Martyna, Wyrwa, Michał, Tussupkaliyev, Akylbek, Tykarski, Andrzej, Mikuła-Pietrasik, Justyna, Książek, Krzysztof

“…Various types of normal and cancer cells undergo senescence in response to carboplatin and paclitaxel, which are considered the gold standard treatments in…”
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Malignant ascites determine the transmesothelial invasion of ovarian cancer cells by Mikuła-Pietrasik, Justyna, Uruski, Paweł, Szubert, Sebastian, Szpurek, Dariusz, Sajdak, Stefan, Tykarski, Andrzej, Książek, Krzysztof

“…[Display omitted] •Malignant ascites promote invasion of ovarian cancer cells.•Ascites from type II tumors are more proinvasive than those from type I…”
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Impact of chronic HCV treatment on quality of life of patients with metabolic disorders in context of immunological disturbances by Kierepa, Agata, Witkowska, Aleksandra, Kaczmarek, Mariusz, Książek, Krzysztof, Mikuła-Pietrasik, Justyna, Żeromski, Jan, Kowala-Piaskowska, Arleta, Mozer-Lisewska, Iwona

“…Chronic viral hepatitis C (CHC) and its complications have a negative effect on patient’s quality of life. We evaluated the impact of a successful…”
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Mechanisms of carboplatin- and paclitaxel-dependent induction of premature senescence and pro-cancerogenic conversion of normal peritoneal mesothelium and fibroblasts by Rutecki, Szymon, Pakuła-Iwańska, Martyna, Leśniewska-Bocianowska, Agnieszka, Matuszewska, Julia, Rychlewski, Daniel, Uruski, Paweł, Stryczyński, Łukasz, Naumowicz, Eryk, Szubert, Sebastian, Tykarski, Andrzej, Mikuła-Pietrasik, Justyna, Książek, Krzysztof

“…Carboplatin (CPT) and paclitaxel (PCT) are the optimal non-surgical treatment of epithelial ovarian cancer (EOC). Although their growth-restricting influence…”
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Senescence-related deterioration of intercellular junctions in the peritoneal mesothelium promotes the transmesothelial invasion of ovarian cancer cells by Pakuła, Martyna, Witucka, Anna, Uruski, Paweł, Radziemski, Artur, Moszyński, Rafał, Szpurek, Dariusz, Maksin, Konstantin, Woźniak, Aldona, Sajdak, Stefan, Tykarski, Andrzej, Mikuła-Pietrasik, Justyna, Książek, Krzysztof

“…Mechanisms of transmesothelial invasion of ovarian cancer are still poorly understood. Here we examined whether this phenomenon may be determined by an…”
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