Evaluation of wound healing activity of ferulic acid in diabetic rats

Evaluation of wound healing activity of ferulic acid in diabetic rats

In diabetic patients, there is impairment in angiogenesis, neovascularisation and failure in matrix metalloproteineases (MMPs), keratinocyte and fibroblast functions, which affects wound healing mechanism. Hence, diabetic patients are more prone to infections and ulcers, which finally result in gang...

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Bibliographic Details
Published in:International wound journal Vol. 11; no. 5; pp. 523 - 532
Main Authors: Ghaisas, Mahesh M, Kshirsagar, Shashank B, Sahane, Rajkumari S
Format: Journal Article
Language:English
Published: Oxford, UK Blackwell Publishing Ltd 01-10-2014
Subjects:
Animals
Antioxidants - pharmacology
Coumaric Acids - pharmacology
Diabetes Mellitus, Experimental - chemically induced
Diabetic wound healing
Disease Models, Animal
Excision wound model
Female
Ferulic acid
Hexosamine
Hydroxyproline
Male
Original
Rats
Rats, Wistar
Skin - injuries
Streptozocin
Wound Healing - drug effects
Wounds and Injuries - drug therapy
Hexosamine
Excision wound model
Hydroxyproline
Diabetic wound healing
Ferulic acid
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Summary:In diabetic patients, there is impairment in angiogenesis, neovascularisation and failure in matrix metalloproteineases (MMPs), keratinocyte and fibroblast functions, which affects wound healing mechanism. Hence, diabetic patients are more prone to infections and ulcers, which finally result in gangrene. Ferulic acid (FA) is a natural antioxidant found in fruits and vegetables, such as tomatoes, rice bran and sweet corn. In this study, wound healing activity of FA was evaluated in streptozotocin‐induced diabetic rats using excision wound model. FA‐treated wounds were found to epithelise faster as compared with diabetic wound control group. The hydroxyproline and hexosamine content increased significantly when compared with diabetic wound control. FA effectively inhibited the lipid peroxidation and elevated the catalase, superoxide dismutase, glutathione and nitric oxide levels along with the increase in the serum zinc and copper levels probably aiding the wound healing process. Hence, the results indicate that FA significantly promotes wound healing in diabetic rats.
Bibliography:ArticleID:IWJ1119
istex:D561E687C191E6BF42306E3110B7564273C25172
ark:/67375/WNG-TC398P81-6
ISSN:1742-4801
1742-481X
DOI:10.1111/j.1742-481X.2012.01119.x