Search Results - "Krzystek, Thomas J."

Differential mitochondrial roles for α-synuclein in DRP1-dependent fission and PINK1/Parkin-mediated oxidation by Krzystek, Thomas J., Banerjee, Rupkatha, Thurston, Layne, Huang, JianQiao, Swinter, Kelsey, Rahman, Saad Navid, Falzone, Tomas L., Gunawardena, Shermali

“…Mitochondria are highly dynamic organelles with strict quality control processes that maintain cellular homeostasis. Within axons, coordinated cycles of…”
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Excess Rab4 rescues synaptic and behavioral dysfunction caused by defective HTT-Rab4 axonal transport in Huntington's disease by White, 2nd, Joseph A, Krzystek, Thomas J, Hoffmar-Glennon, Hayley, Thant, Claire, Zimmerman, Katherine, Iacobucci, Gary, Vail, Julia, Thurston, Layne, Rahman, Saad, Gunawardena, Shermali

“…Huntington's disease (HD) is characterized by protein inclusions and loss of striatal neurons which result from expanded CAG repeats in the poly-glutamine…”
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HTT (huntingtin) and RAB7 co-migrate retrogradely on a signaling LAMP1-containing late endosome during axonal injury by Krzystek, Thomas J., White, Joseph A., Rathnayake, Rasika, Thurston, Layne, Hoffmar-Glennon, Hayley, Li, Yichen, Gunawardena, Shermali

“…HTT (huntingtin) is a 350-kDa protein of unknown function. While HTT moves bidirectionally within axons and HTT loss/reduction causes axonal transport defects,…”
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