Search Results - "Krzych, Urszula"

Identification of a Novel CD8 T Cell Epitope Derived from Plasmodium berghei Protective Liver-Stage Antigen by Pichugin, Alexander, Zarling, Stasya, Perazzo, Leah, Duffy, Patrick Emmet, Ploegh, Hidde Lolke, Krzych, Urszula

“…We recently identified novel (Pb) liver stage (LS) genes that as DNA vaccines significantly reduce Pb LS parasite burden (LPB) in C57Bl/6 (B6) mice through a…”
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Protective immunity induced with the RTS,S/AS vaccine is associated with IL-2 and TNF-α producing effector and central memory CD4 T cells by Lumsden, Joanne M, Schwenk, Robert J, Rein, Lisa E, Moris, Philippe, Janssens, Michel, Ofori-Anyinam, Opokua, Cohen, Joe, Kester, Kent E, Heppner, D Gray, Krzych, Urszula

“…A phase 2a RTS,S/AS malaria vaccine trial, conducted previously at the Walter Reed Army Institute of Research, conferred sterile immunity against a primary…”
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Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design by VanBuskirk, Kelley M, O'Neill, Matthew T, De La Vega, Patricia, Maier, Alexander G, Krzych, Urszula, Williams, Jack, Dowler, Megan G, Sacci, John B. Jr, Kangwanrangsan, Niwat, Tsuboi, Takafumi, Kneteman, Norman M, Heppner, Donald G. Jr, Murdock, Brant A, Mikolajczak, Sebastian A, Aly, Ahmed S.I, Cowman, Alan F, Kappe, Stefan H.I

“…Falciparum malaria is initiated when Anopheles mosquitoes transmit the Plasmodium sporozoite stage during a blood meal. Irradiated sporozoites confer sterile…”
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Identification of Novel Pre-Erythrocytic Malaria Antigen Candidates for Combination Vaccines with Circumsporozoite Protein by Speake, Cate, Pichugin, Alexander, Sahu, Tejram, Malkov, Vlad, Morrison, Robert, Pei, Ying, Juompan, Laure, Milman, Neta, Zarling, Stasya, Anderson, Charles, Wong-Madden, Sharon, Wendler, Jason, Ishizuka, Andrew, MacMillen, Zachary W, Garcia, Valentino, Kappe, Stefan H I, Krzych, Urszula, Duffy, Patrick E

“…Malaria vaccine development has been hampered by the limited availability of antigens identified through conventional discovery approaches, and improvements…”
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Disruption of the Plasmodium falciparum liver‐stage antigen‐1 locus causes a differentiation defect in late liver‐stage parasites by Mikolajczak, Sebastian A., Sacci, Jr, John B., De La Vega, Patricia, Camargo, Nelly, VanBuskirk, Kelly, Krzych, Urszula, Cao, Jun, Jacobs‐Lorena, Marcelo, Cowman, Alan F., Kappe, Stefan H. I.

“…Summary The malaria parasite Plasmodium falciparum infects humans and first targets the liver where liver‐stage parasites undergo pre‐erythrocytic replication…”
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Quantification of sporozoite invasion, migration, and development by microscopy and flow cytometry by Sinnis, Photini, De La Vega, Patricia, Coppi, Alida, Krzych, Urszula, Mota, Maria M

“…There is an important role for in vitro assays to better understand the initial steps of malaria infection. In this section, we describe both microscopy-based…”
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Critical Reviews in Immunology by Krzych, Urszula

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Eli’s Propinquity is Far Reaching, from Escherichia coli β-Galactosidase to the Plasmodium Parasite by Krzych, Urszula

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The Form of an Antigen and Its Molecular Context Do Matter: Infectious versus Attenuated Plasmodium Sporozoites by Krzych, Urszula, Althubaiti, Nouf

“…The physicochemical properties of an antigen (Ag) influence the type, specificity, as well as duration of emerging immune responses. Like immune responses…”
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Critical Reviews in Immunology by Althubaiti, Nouf, Krzych, Urszula

“…The physicochemical properties of an antigen (Ag) influence the type, specificity, as well as duration of emerging immune responses. Like immune responses…”
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Characterization of Liver CD8 T Cell Subsets that are Associated with Protection Against Pre-erythrocytic Plasmodium Parasites by Zarling, Stasya, Krzych, Urszula

“…Murine models of malaria, such as Plasmodium berghei (Pb) and Plasmodium yoelii (Py), have been used for decades to identify correlates of protection…”
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Detection of Plasmodium berghei and Plasmodium yoelii Liver-Stage Parasite Burden by Quantitative Real-Time PCR by Pichugin, Alexander, Krzych, Urszula

“…Direct detection and quantification of liver-stage Plasmodium parasites became possible with the development of quantitative real-time PCR (qPCR). Here we…”
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Increased apoptosis of intrahepatic central memory CD8 T cells in the absence of IL-15 is attributed to the loss of long-lasting protection against malaria infection (P3334) by Zarling, Stasya, Krzych, Urszula

“…Abstract Ag-specific memory T cell responses elicited by infections or vaccinations are inextricably linked to long-lasting protective immunity. Studies of…”
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Memory T cells maintain protracted protection against malaria by Krzych, Urszula, Zarling, Stasya, Pichugin, Alexander

“…Highlights • The mammalian liver serves as the venue for Plasmodium parasite development. • Sterile and lasting protection is inducible by exposure to…”
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Prime-Trap immunization with protective liver stage antigen, MIF-4G and Kb17 peptide, induces liver CD8 TRM cells and protection against Plasmodium berghei malaria by Krzych, Urszula, Althubaiti, Nouf, Pichugin, Alexander V, Duffy, Patrick E, Zarling, Stasya N

“…Abstract Exposure to Plasmodium sporozoites (spz), the causative agent of malaria, induces anti-disease immunity, but fails to protect against repeated…”
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Induction of T Helper Type 1 and 2 Responses to 19-Kilodalton Merozoite Surface Protein 1 in Vaccinated Healthy Volunteers and Adults Naturally Exposed to Malaria by LEE, Edwin A. M, PALMER, Dupeh R, DIGGS, Carter, KASLOW, David, APOSTOLOPOULOS, V, BALLOU, W. Ripley, HILL, Adrian V. S, KRZYCH, Urszula, PLEBANSKI, Magdalena, FLANAGAN, Katie L, REECE, William H. H, ODHIAMBO, Kennedy, MARSH, Kevin, PINDER, Margaret, GRAVENOR, Michael B, KEITEL, Wendy A, KESTER, Kent E

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Plasmodium falciparum mRNA liver stage antigens induce antibody and liver CD8 TRM and CD8 T Ecell responses in mice by Tan, Steven, Alameh, Mohamad-Gabriel, Renn, Jonathan P, Allen, Joselyn Natasha, Pichugin, Alexander V, Duffy, Patrick E, Weissman, Drew, Krzych, Urszula

“…Abstract Plasmodium spp. cause more than half a million malaria deaths annually and the only approved vaccine, RTS,S, based on P.falciparum (Pf)…”
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Immunization with radiation-attenuated Plasmodium berghei sporozoites induces liver cCD8alpha+DC that activate CD8+T cells against liver-stage malaria by Jobe, Ousman, Donofrio, Gina, Sun, Guangping, Liepinsh, Dmitry, Schwenk, Robert, Krzych, Urszula

“…Immunization with radiation (gamma)-attenuated Plasmodia sporozoites (gamma-spz) confers sterile and long-lasting immunity against malaria liver-stage…”
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Plasmodium cellular effector mechanisms and the hepatic microenvironment by Frevert, Ute, Krzych, Urszula

“…Plasmodium falciparum malaria remains one of the most serious health problems globally. Immunization with attenuated parasites elicits multiple cellular…”
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The survival of memory CD8 T cells that is mediated by IL-15 correlates with sustained protection against malaria by Zarling, Stasya, Berenzon, Dmitriy, Dalai, Sarat, Liepinsh, Dmitry, Steers, Nick, Krzych, Urszula

“…Ag-specific memory T cell responses elicited by infections or vaccinations are inextricably linked to long-lasting protective immunity. Studies of protective…”
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