Search Results - "Krzyścik, Mateusz Adam"

Intrinsically Fluorescent Oligomeric Cytotoxic Conjugates Toxic for FGFR1-Overproducing Cancers by Porębska, Natalia, Knapik, Agata, Poźniak, Marta, Krzyścik, Mateusz Adam, Zakrzewska, Małgorzata, Otlewski, Jacek, Opaliński, Łukasz

“…Fibroblast growth factor receptor 1 (FGFR1) is an integral membrane protein that transmits prolife signals through the plasma membrane. Overexpression of FGFR1…”
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The cytotoxic conjugate of highly internalizing tetravalent antibody for targeting FGFR1-overproducing cancer cells by Poźniak, Marta, Porębska, Natalia, Krzyścik, Mateusz Adam, Sokołowska-Wędzina, Aleksandra, Jastrzębski, Kamil, Sochacka, Martyna, Szymczyk, Jakub, Zakrzewska, Małgorzata, Otlewski, Jacek, Opaliński, Łukasz

“…Antibody drug conjugates (ADCs) represent one of the most promising approaches in the current immuno-oncology research. The precise delivery of cytotoxic drugs…”
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The Significance of Cell Surface N-Glycosylation for Internalization and Potency of Cytotoxic Conjugates Targeting Receptor Tyrosine Kinases by Poźniak, Marta, Żukowska, Dominika, Gędaj, Aleksandra, Krzyścik, Mateusz Adam, Porębska, Natalia, Zakrzewska, Małgorzata, Otlewski, Jacek, Opaliński, Łukasz

“…Precise anticancer therapies employing cytotoxic conjugates constitute a side-effect-limited, highly attractive alternative to commonly used cancer treatment…”
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Modular self-assembly system for development of oligomeric, highly internalizing and potent cytotoxic conjugates targeting fibroblast growth factor receptors by Poźniak, Marta, PorÄbska, Natalia, JastrzÄbski, Kamil, KrzyÅcik, Mateusz Adam, KuciÅska, Marika, Zarzycka, Weronika, Barbach, Agnieszka, Zakrzewska, MaÅgorzata, Otlewski, Jacek, MiÄczyÅska, Marta, OpaliÅski, Åukasz

“…Background Overexpression of FGFR1 is observed in numerous tumors and therefore this receptor constitutes an attractive molecular target for selective cancer…”
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Methotrexate and epirubicin conjugates as potential antitumor drugs by Kmiecik, Szymon Wojciech, Krzyścik, Mateusz Adam, Filip-Psurska, Beata, Wietrzyk, Joanna, Boratyński, Janusz, Goszczyński, Tomasz Marek

“…The use of hybrid molecules has become one of the most significant approaches in new cytotoxic drug design. This study describes synthesis and characterization…”
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Dual-Warhead Conjugate Based on Fibroblast Growth Factor 2 Dimer Loaded with α-Amanitin and Monomethyl Auristatin E Exhibits Superior Cytotoxicity towards Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1 by Nawrocka, Daria, Krzyscik, Mateusz Adam, Sluzalska, Katarzyna Dominika, Otlewski, Jacek

“…Targeting fibroblast growth factor receptor 1 (FGFR1) is a promising therapeutic strategy for various cancers associated with alterations in the FGFR1 gene. In…”
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Stable Fibroblast Growth Factor 2 Dimers with High Pro-Survival and Mitogenic Potential by Nawrocka, Daria, Krzyscik, Mateusz Adam, Opaliński, Łukasz, Zakrzewska, Malgorzata, Otlewski, Jacek

“…Fibroblast growth factor 2 (FGF2) is a heparin-binding growth factor with broad mitogenic and cell survival activities. Its effector functions are induced upon…”
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Peptibody Based on FGFR1-Binding Peptides From the FGF4 Sequence as a Cancer-Targeting Agent by Jendryczko, Karolina, Rzeszotko, Jakub, Krzyscik, Mateusz Adam, Szymczyk, Jakub, Otlewski, Jacek, Szlachcic, Anna

“…Targeted therapies are a promising alternative to conventional chemotherapy, with an increasing number of therapeutics targeting specific molecular aberrancies…”
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FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization by Pozniak, Marta, Sokolowska‐Wedzina, Aleksandra, Jastrzebski, Kamil, Szymczyk, Jakub, Porebska, Natalia, Krzyscik, Mateusz Adam, Zakrzewska, Malgorzata, Miaczynska, Marta, Otlewski, Jacek, Opalinski, Lukasz

“…Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility,…”
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Cytotoxic Conjugates of Fibroblast Growth Factor 2 (FGF2) with Monomethyl Auristatin E for Effective Killing of Cells Expressing FGF Receptors by Krzyscik, Mateusz Adam, Zakrzewska, Malgorzata, Sørensen, Vigdis, Sokolowska-Wedzina, Aleksandra, Lobocki, Michal, Swiderska, Karolina Weronika, Krowarsch, Daniel, Wiedlocha, Antoni, Otlewski, Jacek

“…Antibody–drug conjugates (ADCs) are a new class of anticancer therapeutics that combine the selectivity of targeted treatment, ensured by monoclonal…”
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Abstract 1917: HER2-FGFR1 interaction induced by bispecific molecules: A novel strategy for treating breast cancer by Krzyscik, Mateusz Adam, Hristova, Kalina

“…Breast cancer poses a significant global health challenge, demanding effective therapies targeting specific receptors. In our prior study, we engineered…”
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Site-Specific, Stoichiometric-Controlled, PEGylated Conjugates of Fibroblast Growth Factor 2 (FGF2) with Hydrophilic Auristatin Y for Highly Selective Killing of Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1 (FGFR1) by Krzyscik, Mateusz Adam, Zakrzewska, Małgorzata, Otlewski, Jacek

“…In spite of significant progress in the field of targeted anticancer therapy, the FDA has approved only five ADC-based drugs. Hence the search for new targeted…”
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Novel Method for Preparation of Site-Specific, Stoichiometric-Controlled Dual Warhead Conjugate of FGF2 via Dimerization Employing Sortase A‑Mediated Ligation by Krzyscik, Mateusz Adam, Opaliński, Łukasz, Otlewski, Jacek

“…Targeted therapies are rapidly evolving modalities of cancer treatment. The largest group of currently developed biopharmaceuticals is antibody–drug conjugates…”
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Drug Conjugation via Maleimide–Thiol Chemistry Does Not Affect Targeting Properties of Cysteine-Containing Anti-FGFR1 Peptibodies by Jendryczko, Karolina, Rzeszotko, Jakub, Krzyscik, Mateusz Adam, Kocyła, Anna, Szymczyk, Jakub, Otlewski, Jacek, Szlachcic, Anna

“…With a wide range of available cytotoxic therapeutics, the main focus of current cancer research is to deliver them specifically to the cancer cells,…”
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Dissecting biological activities of fibroblast growth factor receptors by the coiled-coil-mediated oligomerization of FGF1 by Porebska, Natalia, Pozniak, Marta, Krzyscik, Mateusz Adam, Knapik, Agata, Czyrek, Aleksandra, Kucinska, Marika, Jastrzebski, Kamil, Zakrzewska, Malgorzata, Otlewski, Jacek, Opalinski, Lukasz

“…Fibroblast growth factor receptors (FGFRs) are integral membrane proteins involved in various biological processes including proliferation, migration and…”
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Nanodiamonds as “artificial proteins”: Regulation of a cell signalling system using low nanomolar solutions of inorganic nanocrystals by Balek, Lukas, Buchtova, Marcela, Kunova Bosakova, Michaela, Varecha, Miroslav, Foldynova-Trantirkova, Silvie, Gudernova, Iva, Vesela, Iva, Havlik, Jan, Neburkova, Jitka, Turner, Stuart, Krzyscik, Mateusz Adam, Zakrzewska, Malgorzata, Klimaschewski, Lars, Claus, Peter, Trantirek, Lukas, Cigler, Petr, Krejci, Pavel

“…The blocking of specific protein-protein interactions using nanoparticles is an emerging alternative to small molecule-based therapeutic interventions…”
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Fibroblast growth factor 2 conjugated with monomethyl auristatin E inhibits tumor growth in a mouse model by Krzyscik, Mateusz Adam, Zakrzewska, Malgorzata, Sørensen, Vigdis, Øy, Geir Frode, Bruheim, Skjalg, Haugsten, Ellen Margrethe, Mælandsmo, Gunhild Mari, Wiedlocha, Antoni, Otlewski, Jacek

“…Worldwide, cancer is the second leading cause of death. Regardless of the continuous progress in medicine, we still do not have a fully effective anti-cancer…”
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Fibroblast Growth Factor 2 Conjugated with Monomethyl Auristatin E Inhibits Tumor Growth in a Mouse Model by Krzyscik, Mateusz A, Zakrzewska, Malgorzata, Sørensen, Vigdis, Øy, Geir Frode, Brunheim, Skjalg, Haugsten, Ellen M, Mælandsmo, Gunhild M, Wiedlocha, Antoni, Otlewski, Jacek

“…Worldwide, cancer is the second leading cause of death. Regardless of the continuous progress in medicine, we still do not have a fully effective anti-cancer…”
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Preparation of Site-Specific Cytotoxic Protein Conjugates via Maleimide-thiol Chemistry and Sortase A-Mediated Ligation by Krzyscik, Mateusz Adam, Sokolowska-Wedzina, Aleksandra, Jendryczko, Karolina, Pozniak, Marta, Nawrocka, Daria, Porebska, Natalia, Zakrzewska, Malgorzata, Otlewski, Jacek, Szlachcic, Anna, Opalinski, Lukasz

“…Cancer is currently the second most common cause of death worldwide. The hallmark of cancer cells is the presence of specific marker proteins such as growth…”
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