Differential Diagnosis of Rare Subtypes of Progressive Supranuclear Palsy and PSP-Like Syndromes-Infrequent Manifestations of the Most Common Form of Atypical Parkinsonism

Differential Diagnosis of Rare Subtypes of Progressive Supranuclear Palsy and PSP-Like Syndromes-Infrequent Manifestations of the Most Common Form of Atypical Parkinsonism

Presently, there is increasing interest in rare PSP (progressive supranuclear palsy) variants, including PSP-PGF (PSP-progressive gait freezing), PSP-PI (PSP-postural instability), PSP-OM (PSP-ocular motor dysfunction), PSP-C (PSP-predominant cerebellar ataxia), PSP-CBS (PSP-corticobasal syndrome),...

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Bibliographic Details
Published in:Frontiers in aging neuroscience Vol. 14; p. 804385
Main Authors: Krzosek, Patrycja, Madetko, Natalia, Migda, Anna, Migda, Bartosz, Jaguś, Dominika, Alster, Piotr
Format: Journal Article
Language:English
Published: Switzerland Frontiers Research Foundation 09-02-2022
Frontiers Media S.A
Subjects:
Aging
Alzheimer's disease
Ataxia
Atrophy
Basal ganglia
Brain diseases
Central nervous system diseases
Differential diagnosis
differentiation
Gait
Magnetic resonance imaging
Medical diagnosis
Metabolism
Mimicry
Movement disorders
Neurodegenerative diseases
Neuroscience
Older people
Paralysis
Parkinson's disease
Patients
Phenotypes
Posture
Progressive supranuclear palsy
Proteins
PSP-like syndrome
subtypes
variants
differentiation
variants
PSP-like syndrome
progressive supranuclear palsy
subtypes
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Summary:Presently, there is increasing interest in rare PSP (progressive supranuclear palsy) variants, including PSP-PGF (PSP-progressive gait freezing), PSP-PI (PSP-postural instability), PSP-OM (PSP-ocular motor dysfunction), PSP-C (PSP-predominant cerebellar ataxia), PSP-CBS (PSP-corticobasal syndrome), PSP-SL (PSP-speech/language disorders), and PSP-PLS (PSP-primary lateral sclerosis). Diagnosis of these subtypes is usually based on clinical symptoms, thus thorough examination with anamnesis remains a major challenge for clinicians. The individual phenotypes often show great similarity to various neurodegenerative diseases and other genetic, autoimmune, or infectious disorders, manifesting as PSP-mimicking syndromes. At the current stage of knowledge, it is not possible to isolate a specific marker to make a definite ante-mortem diagnosis. The purpose of this review is to discuss recent developments in rare PSP phenotypes and PSP-like syndromes.
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This article was submitted to Parkinson’s Disease and Aging-related Movement Disorders, a section of the journal Frontiers in Aging Neuroscience
Reviewed by: Philip Wade Tipton, Mayo Clinic Florida, United States; Shan Ali, Mayo Clinic Florida, United States
Edited by: Wenquan Zou, Case Western Reserve University, United States
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2022.804385