Search Results - "Krystek, Stanley R."

AggScore: Prediction of aggregation‐prone regions in proteins based on the distribution of surface patches by Sankar, Kannan, Krystek, Stanley R., Carl, Stephen M., Day, Tyler, Maier, Johannes K. X.

“…Protein aggregation is a phenomenon that has attracted considerable attention within the pharmaceutical industry from both a developability standpoint (to…”
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Isomerization and Oxidation in the Complementarity-Determining Regions of a Monoclonal Antibody: A Study of the Modification–Structure–Function Correlations by Hydrogen–Deuterium Exchange Mass Spectrometry by Yan, Yuetian, Wei, Hui, Fu, Ya, Jusuf, Sutjano, Zeng, Ming, Ludwig, Richard, Krystek, Stanley R, Chen, Guodong, Tao, Li, Das, Tapan K

“…Chemical modifications can potentially change monoclonal antibody’s (mAb) local or global conformation and therefore impact their efficacy as therapeutic…”
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Design for Solubility May Reveal Induction of Amide Hydrogen/Deuterium Exchange by Protein Self-Association by Trainor, Kyle, Doyle, Colleen M., Metcalfe-Roach, Avril, Steckner, Julia, Lipovšek, Daša, Malakian, Heather, Langley, David, Krystek Jr, Stanley R., Meiering, Elizabeth M.

“…[Display omitted] •Adnectin scaffold solubility is improved by combined bioinformatic and CamSol analysis.•Adnectins differing at a single amino acid position…”
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Structures of Adnectin/Protein Complexes Reveal an Expanded Binding Footprint by Ramamurthy, Vidhyashankar, Krystek, Stanley R., Bush, Alexander, Wei, Anzhi, Emanuel, Stuart L., Das Gupta, Ruchira, Janjua, Ahsen, Cheng, Lin, Murdock, Melissa, Abramczyk, Bozena, Cohen, Daniel, Lin, Zheng, Morin, Paul, Davis, Jonathan H., Dabritz, Michael, McLaughlin, Douglas C., Russo, Katie A., Chao, Ginger, Wright, Martin C., Jenny, Victoria A., Engle, Linda J., Furfine, Eric, Sheriff, Steven

“…Adnectins are targeted biologics derived from the tenth type III domain of human fibronectin (10Fn3), a member of the immunoglobulin superfamily…”
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Development and scale-up of the recovery and purification of a domain antibody Fc fusion protein-comparison of a two and three-step approach by Herzer, Sibylle, Bhangale, Atul, Barker, Gregory, Chowdhary, Isha, Conover, Matthew, O'Mara, Brian W., Tsang, Lily, Wang, Shi-Yu, Krystek Jr, Stanley R., Yao, Yan, Rieble, Siegfried

“…ABSTRACT A robust, economical process should leverage proven technology, yet be flexible enough to adopt emerging technologies which show significant benefit…”
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Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and Alanine Shave Mutagenesis by Li, Jing, Wei, Hui, Krystek, Stanley R, Bond, Derek, Brender, Ty M, Cohen, Daniel, Feiner, Jena, Hamacher, Nels, Harshman, Johanna, Huang, Richard Y.-C, Julien, Susan H, Lin, Zheng, Moore, Kristina, Mueller, Luciano, Noriega, Claire, Sejwal, Preeti, Sheppard, Paul, Stevens, Brenda, Chen, Guodong, Tymiak, Adrienne A, Gross, Michael L, Schneeweis, Lumelle A

“…Epitope mapping the specific residues of an antibody/antigen interaction can be used to support mechanistic interpretation, antibody optimization, and epitope…”
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Hydrogen/deuterium exchange mass spectrometry and computational modeling reveal a discontinuous epitope of an antibody/TL1A Interaction by Huang, Richard Y-C, Krystek, Jr, Stanley R, Felix, Nathan, Graziano, Robert F, Srinivasan, Mohan, Pashine, Achal, Chen, Guodong

“…TL1A, a tumor necrosis factor-like cytokine, is a ligand for the death domain receptor DR3. TL1A, upon binding to DR3, can stimulate lymphocytes and trigger…”
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Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope by Yamniuk, Aaron P., Suri, Anish, Krystek, Stanley R., Tamura, James, Ramamurthy, Vidhyashankar, Kuhn, Robert, Carroll, Karen, Fleener, Catherine, Ryseck, Rolf, Cheng, Lin, An, Yongmi, Drew, Philip, Grant, Steven, Suchard, Suzanne J., Nadler, Steven G., Bryson, James W., Sheriff, Steven

“…Current clinical anti-CD40 biologic agents include both antagonist molecules for the treatment of autoimmune diseases and agonist molecules for…”
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Mapping the Binding Interface in a Noncovalent Size Variant of a Monoclonal Antibody Using Native Mass Spectrometry, Hydrogen-Deuterium Exchange Mass Spectrometry, and Computational Analysis by Yan, Yuetian, Wei, Hui, Jusuf, Sutjano, Krystek, Jr, Stanley R, Chen, Jie, Chen, Guodong, Ludwig, Richard T, Tao, Li, Das, Tapan K

“…Variants of monoclonal antibody containing an extra light chain have been reported in protein products. Due to potential impact on potency and immunogenicity,…”
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Loopholes and missing links in protein modeling by Rossi, Karen A., Weigelt, Carolyn A., Nayeem, Akbar, Krystek, Stanley R.

“…This paper provides an unbiased comparison of four commercially available programs for loop sampling, Prime, Modeler, ICM, and Sybyl, each of which uses a…”
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Discovery of Potent, Orally-Active, and Muscle-Selective Androgen Receptor Modulators Based on an N-Aryl-hydroxybicyclohydantoin Scaffold by Sun, Chongqing, Robl, Jeffrey A, Wang, Tammy C, Huang, Yanting, Kuhns, Joyce E, Lupisella, John A, Beehler, Blake C, Golla, Rajasree, Sleph, Paul G, Seethala, Ramakrishna, Fura, Aberra, Krystek, Stanley R, An, Yongmi, Malley, Mary F, Sack, John S, Salvati, Mark E, Grover, Gary J, Ostrowski, Jacek, Hamann, Lawrence G

“…A novel, N-aryl-bicyclohydantoin selective androgen receptor modulator scaffold was discovered through structure-guided modifications of androgen receptor…”
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Pharmacological and X-Ray Structural Characterization of a Novel Selective Androgen Receptor Modulator: Potent Hyperanabolic Stimulation of Skeletal Muscle with Hypostimulation of Prostate in Rats by Ostrowski, Jacek, Kuhns, Joyce E, Lupisella, John A, Manfredi, Mark C, Beehler, Blake C, Krystek, Stanley R, Bi, Yingzhi, Sun, Chongqing, Seethala, Ramakrishna, Golla, Rajasree, Sleph, Paul G, Fura, Aberra, An, Yongmi, Kish, Kevin F, Sack, John S, Mookhtiar, Kasim A, Grover, Gary J, Hamann, Lawrence G

“…A novel, highly potent, orally active, nonsteroidal tissue selective androgen receptor (AR) modulator (BMS-564929) has been identified, and this compound has…”
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Discovery of Potent and Muscle Selective Androgen Receptor Modulators through Scaffold Modifications by Li, James J, Sutton, James C, Nirschl, Alexandra, Zou, Yan, Wang, Haixia, Sun, Chongqing, Pi, Zulan, Johnson, Rebecca, Krystek, Stanley R, Seethala, Ramakrishna, Golla, Rajasree, Sleph, Paul G, Beehler, Blake C, Grover, Gary J, Fura, Aberra, Vyas, Viral P, Li, Cindy Y, Gougoutas, Jack Z, Galella, Michael A, Zahler, Robert, Ostrowski, Jacek, Hamann, Lawrence G

“…A novel series of imidazolin-2-ones were designed and synthesized as highly potent, orally active and muscle selective androgen receptor modulators (SARMs),…”
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Biotechnology Based Process for Production of a Disulfide-Bridged Peptide by Goswami, Animesh, Goldberg, Steven L, Hanson, Ronald L, Johnston, Robert M, Lyngberg, Olav K, Chan, Yeung, Lo, Ehrlic, Chan, Steven H, de Mas, Nuria, Ramirez, Antonio, Doyle, Richard, Ding, Wei, Gao, Mian, Krystek, Stanley R, Wan, Changhong, Kim, Yeoun jin, Calambur, Deepa, Witmer, Mark, Bryson, James W

“…A disulfide-bridged peptide drug development candidate contained two oligopeptide chains with 11 and 12 natural amino acids joined by a disulfide bond at the…”
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N-Aryl-oxazolidin-2-imine Muscle Selective Androgen Receptor Modulators Enhance Potency through Pharmacophore Reorientation by Nirschl, Alexandra A, Zou, Yan, Krystek, Stanley R, Sutton, James C, Simpkins, Ligaya M, Lupisella, John A, Kuhns, Joyce E, Seethala, Ramakrishna, Golla, Rajasree, Sleph, Paul G, Beehler, Blake C, Grover, Gary J, Egan, Donald, Fura, Aberra, Vyas, Viral P, Li, Yi-Xin, Sack, John S, Kish, Kevin F, An, Yongmi, Bryson, James A, Gougoutas, Jack Z, DiMarco, John, Zahler, Robert, Ostrowski, Jacek, Hamann, Lawrence G

“…A novel selective androgen receptor modulator (SARM) scaffold was discovered as a byproduct obtained during synthesis of our earlier series of…”
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Closing the side-chain gap in protein loop modeling by Rossi, Karen A., Nayeem, Akbar, Weigelt, Carolyn A., Krystek, Stanley R.

“…The success of structure-based drug design relies on accurate protein modeling where one of the key issues is the modeling and refinement of loops. This study…”
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Chemical genetics reveals an RGS/G-protein role in the action of a compound by Fitzgerald, Kevin, Tertyshnikova, Svetlana, Moore, Lisa, Bjerke, Lynn, Burley, Ben, Cao, Jian, Carroll, Pamela, Choy, Robert, Doberstein, Steve, Dubaquie, Yves, Franke, Yvonne, Kopczynski, Jenny, Korswagen, Hendrik, Krystek, Stanley R, Lodge, Nicholas J, Plasterk, Ronald, Starrett, John, Stouch, Terry, Thalody, George, Wayne, Honey, van der Linden, Alexander, Zhang, Yongmei, Walker, Stephen G, Cockett, Mark, Wardwell-Swanson, Judi, Ross-Macdonald, Petra, Kindt, Rachel M

“…We report here on a chemical genetic screen designed to address the mechanism of action of a small molecule. Small molecules that were active in models of…”
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Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry by Huang, Richard Y.-C., Iacob, Roxana E., Krystek, Stanley R., Jin, Mi, Wei, Hui, Tao, Li, Das, Tapan K., Tymiak, Adrienne A., Engen, John R., Chen, Guodong

“…Aggregation of protein therapeutics has long been a concern across different stages of manufacturing processes in the biopharmaceutical industry. It is often…”
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Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators by Hamann, Lawrence G., Manfredi, Mark C., Sun, Chongqing, Krystek, Stanley R., Huang, Yanting, Bi, Yingzhi, Augeri, David J., Wang, Tammy, Zou, Yan, Betebenner, David. A., Fura, Aberra, Seethala, Ramakrishna, Golla, Rajasree, Kuhns, Joyce E., Lupisella, John A., Darienzo, Celia J., Custer, Laura L., Price, Jennifer L., Johnson, James M., Biller, Scott A., Zahler, Robert, Ostrowski, Jacek

“…SAR relating to the optimization of androgen receptor agonist activity and elimination of mutagenic potential is reported. Pharmacokinetic studies in…”
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The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgen receptor antagonists by Balog, Aaron, Salvati, Mark E., Shan, Weifang, Mathur, Arvind, Leith, Leslie W., Wei, Donna D., Attar, Ricardo M., Geng, Jieping, Rizzo, Cheryl A., Wang, Chihuei, Krystek, Stanley R., Tokarski, John S., Hunt, John T., Gottardis, Marco, Weinmann, Roberto

“…A novel series of [2.2.1]-bicycloazahydantoins has been designed and synthesized in an enantiospecific manner. Several of these compounds were found to act as…”
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