Search Results - "Krystal, C"

RNAi in cell nuclei: potential for a new layer of biological regulation and a new strategy for therapeutic discovery by Johnson, Krystal C, Corey, David R

“…RNA interference is almost always associated with post-transcriptional silencing in the cytoplasm. MicroRNAs (miRNAs) and critical RNAi protein factors like…”
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Argonaute binding within 3′-untranslated regions poorly predicts gene repression by Chu, Yongjun, Kilikevicius, Audrius, Liu, Jing, Johnson, Krystal C, Yokota, Shinnichi, Corey, David R

“…Abstract Despite two decades of study, the full scope of RNAi in mammalian cells has remained obscure. Here we combine: (i) Knockout of argonaute (AGO)…”
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Argonaute binding within human nuclear RNA and its impact on alternative splicing by Chu, Yongjun, Yokota, Shinnichi, Liu, Jing, Kilikevicius, Audrius, Johnson, Krystal C, Corey, David R

“…Mammalian RNA interference (RNAi) is often linked to the regulation of gene expression in the cytoplasm. Synthetic RNAs, however, can also act through the RNAi…”
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Editorial: Nucleic Acids Research virtual issue dedicated to nucleic acid therapeutics, 2018–2023 by Belgrad, Jillian, Fakih, Hassan H, Johnson, Krystal C, Corey, David R

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Nuclear localization of Argonaute 2 is affected by cell density and may relieve repression by microRNAs by Johnson, Krystal C, Kilikevicius, Audrius, Hofman, Cristina, Hu, Jiaxin, Liu, Yang, Aguilar, Selina, Graswich, Jon, Han, Yi, Wang, Tao, Westcott, Jill M, Brekken, Rolf A, Peng, Lan, Karagkounis, Georgios, Corey, David R

“…Abstract Argonaute protein is associated with post-transcriptional control of cytoplasmic gene expression through miRNA-induced silencing complexes (miRISC)…”
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miR‐186 is decreased in aged brain and suppresses BACE1 expression by Kim, Jaekwang, Yoon, Hyejin, Chung, Dah‐eun, Brown, Jennifer L., Belmonte, Krystal C, Kim, Jungsu

“…Accumulation of amyloid β (Aβ) in the brain is a key pathological hallmark of Alzheimer's disease (AD). Because aging is the most prominent risk factor for AD,…”
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miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1) by Kim, Jaekwang, Fiesel, Fabienne C, Belmonte, Krystal C, Hudec, Roman, Wang, Wang-Xia, Kim, Chaeyoung, Nelson, Peter T, Springer, Wolfdieter, Kim, Jungsu

“…Loss-of-function mutations in PINK1 and PARKIN are the most common causes of autosomal recessive Parkinson's disease (PD). PINK1 is a mitochondrial…”
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Need satisfaction and need frustration as distinct and potentially co-occurring constructs: Need profiles examined in physical education and sport by Warburton, Victoria E., Wang, John C. K., Bartholomew, Kimberley J., Tuff, Rebecca L., Bishop, Krystal C. M.

“…We explored the combined relationships between need satisfaction and need frustration and their simultaneous associations with motivation, well-being, and…”
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The inferiority of a virtual subinternship compared with in-person training by Maloni, Krystal C., Calligaro, Keith D.

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Consequences of depleting TNRC6, AGO, and DROSHA proteins on expression of microRNAs by Johnson, Krystal C, Johnson, Samantha T, Liu, Jing, Chu, Yongjun, Arana, Carlos, Han, Yi, Wang, Tao, Corey, David R

“…The potential for microRNAs (miRNAs) to regulate gene expression remains incompletely understood. DROSHA initiates the biogenesis of miRNAs while variants of…”
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Intra- and Inter-individual Variability of microRNA Levels in Human Cerebrospinal Fluid: Critical Implications for Biomarker Discovery by Yoon, Hyejin, Belmonte, Krystal C., Kasten, Tom, Bateman, Randall, Kim, Jungsu

“…MicroRNAs are emerging as promising biomarkers for diagnosis of various diseases. Notably, cerebrospinal fluid (CSF) contains microRNAs that may serve as…”
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Risk of congenital malformations associated with first-trimester exposure to antipsychotics: A propensity score-weighted population-based cohort study by Chan, Joe K N, Lee, Krystal C K, Wong, Corine S M, Chang, Wing C

“…There is growing concern regarding teratogenic effect of antipsychotics. Previous research assessing association between antipsychotics and congenital…”
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A Scoping Review of Definitions of Success in Endovascular Aortic Arch Repair by Rossi, Matthew J, Ilyas, Sadia, Abramowitz, Steven D, De Freitas, Simon, Hockstein, Maxwell A, Maloni, Krystal C, Shults, Christian, Fatima, Javairiah

“…The present standard of care to treat aortic arch pathologies is open surgical repair with cardiopulmonary bypass and deep hypothermic arrest. With approaches…”
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Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription by Hicks, Jessica A., Li, Liande, Matsui, Masayuki, Chu, Yongjun, Volkov, Oleg, Johnson, Krystal C., Corey, David R.

“…In the cytoplasm, small RNAs can control mammalian translation by regulating the stability of mRNA. In the nucleus, small RNAs can also control transcription…”
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Quick Response Codes: An Innovative Approach to Just-in-Time Education by Hirsch, Sonya M., Bueno, Elyse, Tenure, Krystal C.

“…Many nurses are digital natives who have grown up with advanced technology. Bedside competence is essential, and written policies and procedures guide our…”
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Reading Reshapes Stimulus Selectivity in the Visual Word Form Area by Chauhan, Vassiki S, McCook, Krystal C, White, Alex L

“…Reading depends on a brain region known as the "visual word form area" (VWFA) in the left ventral occipitotemporal cortex. This region's function is debated…”
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Outcomes of Kidney Transplantation Among COVID-19 Recovered Patients in a Single Transplant Center by Cervantes, Krystal C., Danguilan, Romina A., Arakama, Mel-Hatra I., Chua, Eric, Abad, Cybele Lara R., Rosete-Liquete, Rose Marie O.

“…The COVID-19 pandemic significantly lowered kidney transplantation (KT) rates worldwide, and studies regarding outcomes of patients who developed COVID-19…”
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Characterization of early communicative behavior in mouse models of neurofibromatosis type 1 by Maloney, Susan E., Chandler, Krystal C., Anastasaki, Corina, Rieger, Michael A., Gutmann, David H., Dougherty, Joseph D.

“…Neurofibromatosis type 1 (NF1) is a monogenic neurodevelopmental disease caused by germline loss‐of‐function mutations in the NF1 tumor suppressor gene…”
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Moyamoya Disease: A Review of Current Literature by Gupta, Apurv, Tyagi, Anshika, Romo, Moises, Amoroso, Krystal C, Sonia, FNU

“…Moyamoya disease (MMD) is an infrequent disease of cerebral vasculature characterized by long-standing and progressive occlusion of large intracranial…”
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Pre-adolescent children's understanding of health and being healthy: a multidimensional perspective from the UK by Warburton, Victoria E., Beaumont, Lee C., Bishop, Krystal C.M.

“…PurposeThe authors applied a multidimensional conceptual lens that incorporated physical, emotional, social, intellectual and spiritual health dimensions to…”
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