Search Results - "Kryshtal, Dmytro O"

RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT by Kryshtal, Dmytro O., Blackwell, Daniel J., Egly, Christian L., Smith, Abigail N., Batiste, Suzanne M., Johnston, Jeffrey N., Laver, Derek R., Knollmann, Bjorn C.

“…The class Ic antiarrhythmic drug flecainide prevents ventricular tachyarrhythmia in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT),…”
Get full text

Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension by Barbaro, Natalia R., Foss, Jason D., Kryshtal, Dmytro O., Tsyba, Nikita, Kumaresan, Shivani, Xiao, Liang, Mernaugh, Raymond L., Itani, Hana A., Loperena, Roxana, Chen, Wei, Dikalov, Sergey, Titze, Jens M., Knollmann, Bjorn C., Harrison, David G., Kirabo, Annet

“…Sodium accumulates in the interstitium and promotes inflammation through poorly defined mechanisms. We describe a pathway by which sodium enters dendritic…”
Get full text

Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories by Hwang, Hyun Seok, Kryshtal, Dmytro O, Feaster, T.K, Sánchez-Freire, Verónica, Zhang, Jianhua, Kamp, Timothy J, Hong, Charles C, Wu, Joseph C, Knollmann, Björn C

“…Abstract Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) are being increasingly used to model human heart diseases. hiPSC-CMs…”
Get full text

Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic by Batiste, Suzanne M., Blackwell, Daniel J., Kim, Kyungsoo, Kryshtal, Dmytro O., Gomez-Hurtado, Nieves, Rebbeck, Robyn T., Cornea, Razvan L., Johnston, Jeffrey N., Knollmann, Bjorn C.

“…Ca2+ leak via ryanodine receptor type 2 (RyR2) can cause potentially fatal arrhythmias in a variety of heart diseases and has also been implicated in…”
Get full text

Coordinated regulation of murine cardiomyocyte contractility by nanomolar (-)-epigallocatechin-3-gallate, the major green tea catechin by Feng, Wei, Hwang, Hyun Seok, Kryshtal, Dmytro O, Yang, Tao, Padilla, Isela T, Tiwary, Asheesh K, Puschner, Birgit, Pessah, Isaac N, Knollmann, Björn C

“…Green tea polyphenolic catechins exhibit biological activity in a wide variety of cell types. Although reports in the lay and scientific literature suggest…”
Get more information

Thyroid and Glucocorticoid Hormones Promote Functional T-Tubule Development in Human-Induced Pluripotent Stem Cell–Derived Cardiomyocytes by Parikh, Shan S., Blackwell, Daniel J., Gomez-Hurtado, Nieves, Frisk, Michael, Wang, Lili, Kim, Kyungsoo, Dahl, Christen P., Fiane, Arnt, Tønnessen, Theis, Kryshtal, Dmytro O., Louch, William E., Knollmann, Bjorn C.

“…Human-induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CM) are increasingly being used for modeling heart disease and are under development for…”
Get full text

Hypertrophic cardiomyopathy-linked mutation in troponin T causes myofibrillar disarray and pro-arrhythmic action potential changes in human iPSC cardiomyocytes by Wang, Lili, Kim, Kyungsoo, Parikh, Shan, Cadar, Adrian Gabriel, Bersell, Kevin R., He, Huan, Pinto, Jose R., Kryshtal, Dmytro O., Knollmann, Bjorn C.

“…Mutations in cardiac troponin T (TnT) are linked to increased risk of ventricular arrhythmia and sudden death despite causing little to no cardiac hypertrophy…”
Get full text

Impaired Dynamic Sarcoplasmic Reticulum Ca Buffering in Autosomal Dominant CPVT2 by Wleklinski, Matthew J., Kryshtal, Dmytro O., Kim, Kyungsoo, Parikh, Shan S., Blackwell, Daniel J., Marty, Isabelle, Iyer, V. Ramesh, Knollmann, Bjӧrn C.

“…Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal cardiac arrhythmia syndrome triggered by catecholamines released during…”
Get full text

Eicosanoid-Regulated Myeloid ENaC and Isolevuglandin Formation in Human Salt-Sensitive Hypertension by Ertuglu, Lale A, Pitzer Mutchler, Ashley, Jamison, Sydney, Laffer, Cheryl L, Elijovich, Fernando, Saleem, Mohammad, Blackwell, Daniel J, Kryshtal, Dmytro O, Egly, Christian L, Sahinoz, Melis, Sheng, Quanhu, Wanjalla, Celestine N, Pakala, Suman, Yu, Justin, Gutierrez, Orlando M, Kleyman, Thomas R, Knollmann, Björn C, Ikizler, T Alp, Kirabo, Annet

“…The mechanisms by which salt increases blood pressure in people with salt sensitivity remain unclear. Our previous studies found that high sodium enters…”
Get full text

Patient-independent human induced pluripotent stem cell model: A new tool for rapid determination of genetic variant pathogenicity in long QT syndrome by Chavali, Nikhil V., Kryshtal, Dmytro O., Parikh, Shan S., Wang, Lili, Glazer, Andrew M., Blackwell, Daniel J., Kroncke, Brett M., Shoemaker, Moore Benjamin, Knollmann, Bjorn C.

“…Commercial genetic testing for long QT syndrome (LQTS) has rapidly expanded, but the inability to accurately predict whether a rare variant is pathogenic has…”
Get full text

Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization by Bersell, Kevin R., Yang, Tao, Mosley, Jonathan D., Glazer, Andrew M., Hale, Andrew T., Kryshtal, Dmytro O., Kim, Kyungsoo, Steimle, Jeffrey D., Brown, Jonathan D., Salem, Joe-Elie, Campbell, Courtney C., Hong, Charles C., Wells, Quinn S., Johnson, Amanda N., Short, Laura, Blair, Marcia A., Behr, Elijah R., Petropoulou, Evmorfia, Jamshidi, Yalda, Benson, Mark D., Keyes, Michelle J., Ngo, Debby, Vasan, Ramachandran S., Yang, Qiong, Gerszten, Robert E., Shaffer, Christian, Parikh, Shan, Sheng, Quanhu, Kannankeril, Prince J., Moskowitz, Ivan P., York, John D., Wang, Thomas J., Knollmann, Bjorn C., Roden, Dan M.

“…Brugada syndrome (BrS) is an inherited arrhythmia syndrome caused by loss-of-function variants in the cardiac sodium channel gene (sodium voltage-gated channel…”
Get full text

Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks by Gomez-Hurtado, Nieves, Boczek, Nicole J, Kryshtal, Dmytro O, Johnson, Christopher N, Sun, Jennifer, Nitu, Florentin R, Cornea, Razvan L, Chazin, Walter J, Calvert, Melissa L, Tester, David J, Ackerman, Michael J, Knollmann, Björn C

“…BACKGROUND—Calmodulin (CaM) mutations are associated with severe forms of long QT syndrome and catecholaminergic polymorphic ventricular tachycardia (CPVT)…”
Get full text

Myofilament Calcium-Buffering Dependent Action Potential Triangulation in Human-Induced Pluripotent Stem Cell Model of Hypertrophic Cardiomyopathy by Wang, Lili, Kryshtal, Dmytro O., Kim, Kyungsoo, Parikh, Shan, Cadar, Adrian Gabriel, Bersell, Kevin Richard, He, Huan, Pinto, Jose R., Knollmann, Bjorn C.

“…[...]the unedited line was the isogenic control line. Pre-treatment with the Ca desensitizer blebbistatin (3 μmol/l) or excess cytosolic buffering (by adding…”
Get full text

Spectrum and Prevalence of CALM1-, CALM2-, and CALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome–Associated Calmodulin Missense Variant, E141G by Boczek, Nicole J, Gomez-Hurtado, Nieves, Ye, Dan, Calvert, Melissa L, Tester, David J, Kryshtal, Dmytro O, Hwang, Hyun Seok, Johnson, Christopher N, Chazin, Walter J, Loporcaro, Christina G, Shah, Maully, Papez, Andrew L, Lau, Yung R, Kanter, Ronald, Knollmann, Björn C, Ackerman, Michael J

“…BACKGROUND—Calmodulin (CaM) is encoded by 3 genes, CALM1, CALM2, and CALM3, all of which harbor pathogenic variants linked to long QT syndrome (LQTS) with…”
Get full text

In Vitro Studies Indicate Intravenous Lipid Emulsion Acts as Lipid Sink in Verapamil Poisoning by Kryshtal, Dmytro O., Dawling, Sheila, Seger, Donna, Knollmann, Bjorn C.

“…Intravenous lipid emulsion (ILE), a component of parenteral nutrition, consists of a fat emulsion of soy bean oil, egg phospholipids, and glycerin. Case…”
Get full text

Impaired calcium-calmodulin-dependent inactivation of Cav1.2 contributes to loss of sarcoplasmic reticulum calcium release refractoriness in mice lacking calsequestrin 2 by Kryshtal, Dmytro O., Gryshchenko, Oleksiy, Gomez-Hurtado, Nieves, Knollmann, Bjorn C.

“…In cardiac muscle, Ca2+ release from sarcoplasmic reticulum (SR) is reduced with successively shorter coupling intervals of premature stimuli, a phenomenon…”
Get full text

Calsequestrin Mutations and Catecholaminergic Polymorphic Ventricular Tachycardia by Faggioni, Michela, Kryshtal, Dmytro O., Knollmann, Björn C.

“…Cardiac calsequestrin (Casq2) is the major Ca 2+ binding protein in the sarcoplasmic reticulum, which is the principle Ca 2+ storage organelle of cardiac…”
Get full text

Human induced pluripotent stem cell (hiPSC) derived cardiomyocytes to understand and test cardiac calcium handling: A glass half full by Hwang, Hyun Seok, Kryshtal, Dmytro O, Feaster, Tromondae K, Sánchez-Freire, Verónica, Zhang, Jianhua, Kamp, Timothy J, Hong, Charles C, Wu, Joseph C, Knollmann, Björn C

Get full text

Autosomal dominant CPVT2 is caused by impaired dynamic calcium buffering in the sarcoplasmic reticulum by Wleklinski, Matthew, Parikh, Shan, Kryshtal, Dmytro O., Knollmann, Bjorn C.

Get full text

Voltage-gated potassium currents in rat vas deferens smooth muscle cells by Harhun, Maksym I, Jurkiewicz, Aron, Jurkiewicz, Neide H, Kryshtal, Dmytro O, Shuba, Michael F, Vladimirova, Irina A

“…Voltage-gated components of the outward current in single smooth muscle cells isolated from the epididymal part of the rat vas deferens were studied using…”
Get full text