Search Results - "Krynetski, Eugene Y."

Preponderance of Thiopurine S-Methyltransferase Deficiency and Heterozygosity Among Patients Intolerant to Mercaptopurine or Azathioprine by EVANS, William E, YUEN YI HON, MURRAY, Jeffrey, QUINN, John, RAVINDRANATH, Y, RITCHEY, Kim, ROBERTS, William, ROGERS, Zora R, SCHIFF, Deborah, STEUBER, Charles, TUCCI, Fabio, KORNEGAY, Nancy, BOMGAARS, Lisa, KRYNETSKI, Eugene Y, RELLING, Mary V, COUTRE, Steve, HOLDSWORTH, Mark, JANCO, Robert, KALWINSKY, David, KELLER, Frank, KHATIB, Ziad, MARGOLIN, Judy

“…To assess thiopurine S-methyltransferase (TPMT) phenotype and genotype in patients who were intolerant to treatment with mercaptopurine (MP) or azathioprine…”
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Structure and Dynamics of Thioguanine-modified Duplex DNA by Somerville, Lilla, Krynetski, Eugene Y, Krynetskaia, Natalia F, Beger, Richard D, Zhang, Weixing, Marhefka, Craig A, Evans, William E, Kriwacki, Richard W

“…Mercaptopurine and thioguanine, two of the most widely used antileukemic agents, exert their cytotoxic, therapeutic effects by being incorporated into DNA as…”
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A Novel CRM1-mediated Nuclear Export Signal Governs Nuclear Accumulation of Glyceraldehyde-3-phosphate Dehydrogenase following Genotoxic Stress by Brown, Victor M., Krynetski, Eugene Y., Krynetskaia, Natalia F., Grieger, Dara, Mukatira, Suraj T., Murti, Kuruganti G., Slaughter, Clive A., Park, Hee-Won, Evans, William E.

“…Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional protein with glycolytic and non-glycolytic functions, including pro-apoptotic activity…”
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Msh2 deficiency attenuates but does not abolish thiopurine hematopoietic toxicity in msh2-/- mice by Krynetskaia, Natalia F, Brenner, Timothy L, Krynetski, Eugene Y, Du, Weinan, Panetta, John C, Ching-Hon, Pui, Evans, William E

“…The amount of MSH2 protein, a major component of the mismatch repair system, was found to differ >10-fold in leukemia cells from children with newly diagnosed…”
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A nuclear protein complex containing high mobility group proteins B1 and B2, heat shock cognate protein 70, ERp60, and glyceraldehyde-3-phosphate dehydrogenase is involved in the cytotoxic response to DNA modified by incorporation of anticancer nucleoside analogues by KRYNETSKI, Eugene Y, KRYNETSKAIA, Natalia F, BIANCHI, Marco E, EVANS, William E

“…Thiopurine treatment of human leukemia cells deficient in components of the mismatch repair system (Nalm6) initiated apoptosis after incorporation into DNA, as…”
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Polymorphism of the Thiopurine S-Methyltransferase Gene in African-Americans by Hon, Yuen Yi, Fessing, Michael Y., Pui, Ching-Hon, Relling, Mary V., Krynetski, Eugene Y., Evans, William E.

“…The molecular basis for the genetic polymorphism of thiopurine S-methyltransferase (TPMT) has been established for Caucasians, but it remains to be elucidated…”
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Enhanced Proteolysis of Thiopurine S-methyltransferase (TPMT) Encoded by Mutant Alleles in Humans (TPMT3A, TPMT2): Mechanisms for the Genetic Polymorphism of TPMT Activity by Tai, Hung-Liang, Krynetski, Eugene Y., Schuetz, Erin G., Yanishevski, Yuri, Evans, William E.

“…TPMT is a cytosolic enzyme that catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including medications such as mercaptopurine and…”
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Pharmacogenetics as a molecular basis for individualized drug therapy : The thiopurine S-methyltransferase paradigm by KRYNETSKI, E. Y, EVANS, W. E

“…Genetic polymorphism of drug metabolizing enzymes can be the major determinant of inter-individual differences in drug disposition and effects. In this…”
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Genetic polymorphism of thiopurine S-methyltransferase: molecular mechanisms and clinical importance by Krynetski, E Y, Evans, W E

“…The activity of thiopurine S-methyltransferase (TPMT) is inherited as an autosomal co-dominant trait. In most large world populations studied to date,…”
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TPMT genetic variations in populations of the Russian Federation by Samochatova, Elena V., Chupova, Natalia V., Rudneva, Anastassia, Makarova, Olga, Nasedkina, Tatyana V., Fedorova, Olga E., Glotov, Andrei S., Kozhekbaeva, Zh, Maiorova, Olga A., Roumyantsev, Alexander G., Krynetski, Eugene Y., Krynetskaia, Natalia F., Evans, William E., Ribeiro, Raul C.

“…Background Polymorphisms that reduce the activity of thiopurine S‐methyltransferase (TPMT) cause adverse reactions to conventional doses of thiopurines,…”
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A Single Point Mutation Leading to Loss of Catalytic Activity in Human Thiopurine S-Methyltransferase by Krynetski, Eugene Y., Schuetz, John D., Galpin, Amy J., Pui, Ching-Hon, Relling, Mary V., Evans, William E.

“…Thiopurine S-methyltransferase (TPMT; S-adenosyl-L-methionine:thiopurine S-methyltransferase, EC 2.1.1.67) activity exhibits genetic polymorphism, with ≈0.33%…”
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A novel protein complex distinct from mismatch repair binds thioguanylated DNA by Krynetski, E Y, Krynetskaia, N F, Gallo, A E, Murti, K G, Evans, W E

“…To elucidate molecular mechanism(s) of cellular response to mercaptopurine, a widely used antileukemic agent, we assessed mercaptopurine (MP) sensitivity in…”
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Human RNase H-mediated RNA cleavage from DNA-RNA duplexes is inhibited by 6-deoxythioguanosine incorporation into DNA by Krynetskaia, N F, Krynetski, E Y, Evans, W E

“…Mercaptopurine and thioguanine are anticancer and immunosuppressive agents that exert their primary cytotoxic effects via incorporation of deoxythioguanosine…”
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Thioguanine substitution alters DNA cleavage mediated by topoisomerase II by Krynetskaia, Natalia F., Cai, Xiangjun, Nitiss, John L., Krynetski, Eugene Y., Relling, Mary V.

“…Thiopurines and topoisomerase II‐targeted drugs (e.g., etoposide) are widely used anticancer drugs. However, topoisomerase II‐targeted drugs can cause acute…”
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Molecular haplotyping of genomic DNA for multiple single-nucleotide polymorphisms located kilobases apart using long-range polymerase chain reaction and intramolecular ligation by MCDONALD, Oliver G, KRYNETSKI, Eugene Y, EVANS, William E

“…Genetic polymorphisms are well-recognized causes of interindividual differences in disease risk and treatment response in humans. For genes containing multiple…”
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Promoter and intronic sequences of the human thiopurine S-methyltransferase (TPMT) gene isolated from a human PAC1 genomic library by KRYNETSKI, E. Y, FESSING, M. Y, YATES, C. R, SUN, D, SCHUETZ, J. D, EVANS, W. E

“…To isolate and characterize the polymorphic human thiopurine S-methyltransferase (TPMT) gene. The human TPMT gene was isolated by PCR screening of a phage…”
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Deoxythioguanosine triphosphate impairs HIV replication: a new mechanism for an old drug by KRYNETSKAIA, NATALIA F., FENG, JOY Y., KRYNETSKI, EUGENE Y., GARCIA, J. VICTOR, PANETTA, JOHN C., ANDERSON, KAREN S., EVANS, WILLIAM E.

“…Inhibition of HIV‐1 reverse transcriptase (RT) and HIV protease are effective mechanisms for anti‐retroviral agents, and the combined use of mechanistically…”
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Molecular cloning and functional characterization of the cDNA encoding the murine thiopurine S-methyltransferase (TPMT) by Fessing, Michael Y, Belkov, Vladimir M, Krynetski, Eugene Y, Evans, William E

“…Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyzes S-methylation of aromatic and heterocyclic sulfhydryl compounds, including…”
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Mercaptopurine Therapy Intolerance and Heterozygosity at the Thiopurine S-Methyltransferase Gene Locus by Relling, Mary V., Hancock, Michael L., Rivera, Gaston K., Sandlund, John T., Ribeiro, Raul C., Krynetski, Eugene Y., Pui, Ching-Hon, Evans, William E.

“…BACKGROUND: Patients with acute lymphoblastic leukemia are often treated with 6-mercaptopurine, and those with homozygous deficiency in thiopurine…”
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Molecular diagnosis of thiopurine S-methyltransferase deficiency : Genetic basis for azathioprine and mercaptopurine intolerance by YATES, C. R, KRYNETSKI, E. Y, LOENNECHEN, T, FESSING, M. Y, TAI, H.-L, PUI, C.-H, RELLING, M. V, EVANS, W. E

“…Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation (that is, inactivation) of mercaptopurine, azathioprine, and thioguanine and exhibits genetic…”
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