Search Results - "Krykbaev, Rustem"

Triad of polar residues implicated in pH specificity of acidic mammalian chitinase by Olland, Andrea M., Strand, James, Presman, Eleonora, Czerwinski, Robert, Joseph‐McCarthy, Diane, Krykbaev, Rustem, Schlingmann, Gerhard, Chopra, Rajiv, Lin, Laura, Fleming, Margaret, Kriz, Ron, Stahl, Mark, Somers, William, Fitz, Lori, Mosyak, Lidia

“…Acidic mammalian chitinase (AMCase) is a mammalian chitinase that has been implicated in allergic asthma. One of only two active mammalian chinases, AMCase, is…”
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IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys by Bree, Andrea, BS, Schlerman, Franklin J., BS, Wadanoli, Michael, DVM, Tchistiakova, Lioudmila, PhD, Marquette, Kimberly, BS, Tan, Xiang-Yang, MD, PhD, Jacobson, Bruce A., PhD, Widom, Angela, MS, Cook, Timothy A., BS, Wood, Nancy, BS, Vunnum, Suresh, PhD, Krykbaev, Rustem, PhD, Xu, Xin, PhD, Donaldson, Debra D., MD, Goldman, Samuel J., PhD, Sypek, Joseph, PhD, Kasaian, Marion T., PhD

“…Background Airway inflammation is a hallmark feature of asthma and a driver of airway hyperresponsiveness. IL-13 is a key inducer of airway inflammation in…”
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Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD) by Wu, Yuchuan, Li, Jianchang, Wu, Junjun, Morgan, Paul, Xu, Xin, Rancati, Fabio, Vallese, Stefania, Raveglia, Luca, Hotchandani, Rajeev, Fuller, Nathan, Bard, Joel, Cunningham, Kristina, Fish, Susan, Krykbaev, Rustem, Tam, Steve, Goldman, Samuel J., Williams, Cara, Mansour, Tarek S., Saiah, Eddine, Sypek, Joseph, Li, Wei

“…X-ray co-structure of compound 26. Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease associated with irreversible progressive…”
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Evolutionary and biochemical differences between human and monkey acidic mammalian chitinases by Krykbaev, Rustem, Fitz, Lori J., Reddy, Padmalatha S., Winkler, Aaron, Xuan, Dejun, Yang, Xiaoke, Fleming, Margaret, Wolf, Stanley F.

“…Acidic mammalian chitinase (AMCase), an enzyme implicated in the pathology of asthma, is capable of chitin cleavage at a low pH optimum. The corresponding gene…”
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Kinetic Characterization of Recombinant Human Acidic Mammalian Chitinase by Chou, Yi-Te, Yao, Shihua, Czerwinski, Robert, Fleming, Margaret, Krykbaev, Rustem, Xuan, Dejun, Zhou, Huanfang, Brooks, Jonathan, Fitz, Lori, Strand, James, Presman, Eleonora, Lin, Laura, Aulabaugh, Ann, Huang, Xinyi

“…Human acidic mammalian chitinase (AMCase), a member of the family 18 glycosyl hydrolases, is one of the important proteins involved in Th2-mediated…”
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DEPCOD: a tool to detect and visualize co-evolution of protein domains by Ji, Fei, Bonilla, Gracia, Krykbaev, Rustem, Ruvkun, Gary, Tabach, Yuval, Sadreyev, Ruslan I

“…Abstract Proteins with similar phylogenetic patterns of conservation or loss across evolutionary taxa are strong candidates to work in the same cellular…”
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Modifying specificity of antidigoxin antibodies using insertional mutagenesis by Krykbaev, Rustem A., Tsantili, Panayota, Jeffrey, Philip D., Margolies, Michael N.

“…Certain antibodies (Abs) elicited using the cardiac glycoside digoxin (digoxigenin tridigitoxoside) bind preferentially to analogs that differ from digoxin by…”
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Complementary Combining Site Contact Residue Mutations of the Anti-digoxin Fab 26–10 Permit High Affinity Wild-type Binding by Short, Mary K., Krykbaev, Rustem A., Jeffrey, Philip D., Margolies, Michael N.

“…Antibody 26–10, obtained in a secondary immune response, binds digoxin with high affinity (Ka = 1.3 × 1010m−1) because of extensive shape complementarity. We…”
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Selective functional inhibition of JAK‐3 is sufficient for efficacy in collagen‐induced arthritis in mice by Lin, Tsung H., Hegen, Martin, Quadros, Elizabeth, Nickerson‐Nutter, Cheryl L., Appell, Kenneth C., Cole, Andrew G., Shao, Yuefei, Tam, Steve, Ohlmeyer, Michael, Wang, Bojing, Goodwin, Debra G., Kimble, Earl F., Quintero, Jorge, Gao, Min, Symanowicz, Peter, Wrocklage, Christopher, Lussier, Jennifer, Schelling, Scott H., Hewet, Amha G., Xuan, Dejun, Krykbaev, Rustem, Togias, Jenny, Xu, Xin, Harrison, Richard, Mansour, Tarek, Collins, Mary, Clark, James D., Webb, Maria L., Seidl, Katherine J.

“…Objective All γ‐chain cytokines signal through JAK‐3 and JAK‐1 acting in tandem. We undertook this study to determine whether the JAK‐3 selective inhibitor…”
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Phage Display-selected Sequences of the Heavy-chain CDR3 Loop of the Anti-digoxin Antibody 26-10 Define a High Affinity Binding Site for Position 16-substituted Analogs of Digoxin by Krykbaev, Rustem A., Liu, W.Robert, Jeffrey, Philip D., Margolies, Michael N.

“…The heavy-chain CDR3 region of the high affinity (Ka = 1.3 × 1010m−1) anti-digoxin monoclonal antibody 26-10 was modified previously to shift its specificity,…”
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A fluorescent assay suitable for inhibitor screening and vanin tissue quantification by Ruan, Benfang H., Cole, Derek C., Wu, Paul, Quazi, Amira, Page, Karen, Wright, Jill F., Huang, Nelson, Stock, Joseph R., Nocka, Karl, Aulabaugh, Ann, Krykbaev, Rustem, Fitz, Lori J., Wolfman, Neil M., Fleming, Margaret L.

“…Vanin-1 is a pantetheinase that catalyzes the hydrolysis of pantetheine to produce pantothenic acid (vitamin B5) and cysteamine. Reported here is a highly…”
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Identification of an Orally Efficacious Matrix Metalloprotease 12 Inhibitor for Potential Treatment of Asthma by Li, Wei, Li, Jianchang, Wu, Yuchuan, Rancati, Fabio, Vallese, Stefania, Raveglia, Luca, Wu, Junjun, Hotchandani, Rajeev, Fuller, Nathan, Cunningham, Kristina, Morgan, Paul, Fish, Susan, Krykbaev, Rustem, Xu, Xin, Tam, Steve, Goldman, Samuel J, Abraham, William, Williams, Cara, Sypek, Joseph, Mansour, Tarek S

“…MMP-12 plays a significant role in airway inflammation and remodeling. Increased expression and production of MMP-12 have been observed in the lungs of…”
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The novel and selective JAK3 inhibitor WYE-152038 is highly efficacious in a mouse model of rheumatoid arthritis by Seidl, Katherine J., Lin, Tsung H., Hegen, Martin, Quadros, Elizabeth, Nickerson-Nutter, Cheryl L., Appell, Kenneth C., Cole, Andrew G., Shao, Yuefei, Tam, Steve, Ohlmeyer, Michael, Wang, Bojing, Goodwin, Debra G., Kimble, Earl F., Quintero, Jorge, Gao, Min, Symanowicz, Peter, Wrocklage, Christopher, Lussier, Jennifer, Schelling, Scott H., Hewet, Amha G., Xuan, Dejun, Krykbaev, Rustem, Togias, Jennifer, Harrison, Richard, Xu, Xin, Collins, Mary, Clark, James D., Webb, Maria L.

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Mutant CD4 Molecules with Improved Binding to HIV Envelope Protein gp120 Selected by Phage Display by Krykbaev, Rustem, McKeating, Jane, Jones, Ian

“…Phage-display methodology has been used to select variant CD4 proteins exhibiting increased binding to the surface envelope glycoprotein, gp120, of Human…”
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Complementary Combining Site Contact Residue Mutations of the Anti-digoxin Fab 26–10 Permit High Affinity Wild-type Binding by Mary K. Short, Rustem A. Krykbaev, Philip D. Jeffrey, Michael N. Margolies

“…Antibody 26–10, obtained in a secondary immune response, binds digoxin with high affinity ( K a = 1.3 × 10 10 m −1 ) because of extensive shape…”
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