Search Results - "Krutzsch, Henry C"

Inhibition of angiogenesis by thrombospondin-1 is mediated by 2 independent regions within the type 1 repeats by IRUELA-ARISPE, M. L, LOMBARDO, M, KRUTZSCH, H. C, LAWLER, J, ROBERTS, D. D

“…Suppression of tumor growth by thrombospondin-1 (TSP-1) has been associated with its ability to inhibit neovascularization. The antiangiogenic activity of…”
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Thrombospondin-1 is a major activator of TGF-β in fibrotic renal disease in the rat in vivo by Daniel, Christoph, Wiede, Julia, Krutzsch, Henry C., Ribeiro, Solange M.F., Roberts, David D., Murphy-Ullrich, Joanne E., Hugo, Christian

“…Thrombospondin-1 is a major activator of TGF-β in fibrotic renal disease in the rat in vivo. Transforming growth factor-β (TGF-β), a profibrotic cytokine…”
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Semenogelins Are Ectopically Expressed in Small Cell Lung Carcinoma by RODRIGUES, Rui G, PANIZO-SANTOS, Angel, CASHEL, Joanne A, KRUTZSCH, Henry C, MERINO, Maria J, ROBERTS, David D

“…Two proteins recovered from cell surface adhesion complexes in a small cell lung carcinoma (SCLC) cell line were identified as fragments of the seminal plasma…”
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Angiogenesis inhibitors target the endothelial cell cytoskeleton through altered regulation of heat shock protein 27 and cofilin by KEEZER, Susan M, IVIE, Susan E, KRUTZSCH, Henry C, TANDLE, Anita, LIBUTTI, Steven K, ROBERTS, David D

“…Inhibition of angiogenesis has emerged as a key focus for the treatment of cancer, necessitating a better understanding of the downstream molecular targets of…”
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α4β1 Integrin Mediates Selective Endothelial Cell Responses to Thrombospondins 1 and 2 In Vitro and Modulates Angiogenesis In Vivo by Calzada, Maria J, Zhou, Longen, Sipes, John M, Zhang, Jane, Krutzsch, Henry C, Iruela-Arispe, M Luisa, Annis, Douglas S, Mosher, Deane F, Roberts, David D

“…ABSTRACT—We examined the function of α4β1 integrin in angiogenesis and in mediating endothelial cell responses to the angiogenesis modulators, thrombospondin-1…”
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Recognition of the N-terminal Modules of Thrombospondin-1 and Thrombospondin-2 by α6β1 Integrin by Calzada, Maria J., Sipes, John M., Krutzsch, Henry C., Yurchenco, Peter D., Annis, Douglas S., Mosher, Deane F., Roberts, David D.

“…In addition to its recognition by α3β1 and α4β1 integrins, the N-terminal pentraxin module of thrombospondin-1 is a ligand for α6β1 integrin. α6β1 integrin…”
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Cell Contact–dependent Activation of α3β1 Integrin Modulates Endothelial Cell Responses to Thrombospondin-1 by Chandrasekaran, Lakshmi, He, Chao-Zhen, Al-Barazi, Hebah, Krutzsch, Henry C., Iruela-Arispe, M. Luisa, Roberts, David D.

“…Thrombospondin-1 (TSP1) can inhibit angiogenesis by interacting with endothelial cell CD36 or proteoglycan receptors. We have now identified α3β1 integrin as…”
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Thrombospondin 1 and type I repeat peptides of thrombospondin 1 specifically induce apoptosis of endothelial cells by GUO, N.-H, KRUTZSCH, H. C, INMAN, J. K, ROBERTS, D. D

“…Thrombospondin 1 (TSP1) inhibits angiogenesis and modulates endothelial cell adhesion, motility, and growth. The antiproliferative activity of TSP1 is mimicked…”
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Identification of an α3β1 Integrin Recognition Sequence in Thrombospondin-1 by Krutzsch, Henry C., Choe, Bertrand J., Sipes, John M., Guo, Neng-hua, Roberts, David D.

“…A synthetic peptide containing amino acid residues 190–201 of thrombospondin-1 (TSP1) promoted adhesion of MDA-MB-435 breast carcinoma cells when immobilized…”
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Inhibition of Retinal Angiogenesis by Peptides Derived from Thrombospondin-1 by Shafiee, Afshin, Penn, John S, Krutzsch, Henry C, Inman, John K, Roberts, David D, Blake, Diane A

“…Thrombospondin (TSP)1 is a tumor suppressor with activity that is associated with its ability to inhibit neovascularization. Previous studies have mapped this…”
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Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development by Rosengard, Ariella M, Krutzsch, Henry C, Shearn, Allen, Biggs, Joseph R, Barker, Edward, Margulies, Inger M. K, King, C. Richter, Liotta, Lance A, Steeg, Patricia S

“…Tumour metastasis is the principal cause of death for cancer patients. We have identified the nm23 gene, for which RNA levels are reduced in tumour cells of…”
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Structural Requirements for Hemoglobin To Induce Fibronectin Receptor Expression in Candida albicans by Pendrak, Michael L, Krutzsch, Henry C, Roberts, David D

“…Hemoglobin (Hb) is a host factor that induces expression of a promiscuous receptor on Candida albicans for fibronectin (FN) and several other extracellular…”
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Heparin- and Sulfatide-Binding Peptides from the Type I Repeats of Human Thrombospondin Promote Melanoma Cell Adhesion by Guo, Neng-Hua, Krutzsch, Henry C., Negre, Eric, Vogel, Tikva, Blake, Diane A., Roberts, David D.

“…Peptides from the three type I repeats of human endothelial cell thrombospondin, containing the consensus sequence-Trp-Ser-Xaa-Trp-, bind to sulfated…”
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Modulation of endothelial cell proliferation, adhesion, and motility by recombinant heparin-binding domain and synthetic peptides from the type I repeats of thrombospondin by Vogel, T, Guo, N H, Krutzsch, H C, Blake, D A, Hartman, J, Mendelovitz, S, Panet, A, Roberts, D D

“…Thrombospondin is an inhibitor of angiogenesis that modulates endothelial cell adhesion, proliferation, and motility. Synthetic peptides from the second type I…”
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Differential Expression of S100C in Thyroid Lesions by Torres-Cabala, Carlos, Panizo-Santos, Angel, Krutzsch, Henry C., Barazi, Heba, Namba, Masayoshi, Sakaguchi, Masakiyo, Roberts, David D., Merino, Maria J.

“…Identification of new potential markers that may help in the diagnosis of benign and malignant thyroid lesions is needed. By comparative 2-dimensional gel…”
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Apolipoprotein E: a potent inhibitor of endothelial and tumor cell proliferation by Vogel, T, Guo, N H, Guy, R, Drezlich, N, Krutzsch, H C, Blake, D A, Panet, A, Roberts, D D

“…Recombinant human apolipoprotein E3 (apoE), purified from E. coli, inhibited the proliferation of several cell types, including endothelial cells and tumor…”
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Differential roles of protein kinase C and pertussis toxin-sensitive G-binding proteins in modulation of melanoma cell proliferation and motility by thrombospondin 1 by GUO, N.-H, ZABRENETZKY, V. S, CHANDRASEKARAN, L, SIPES, J. M, LAWLER, J, KRUTZSCH, H. C, ROBERTS, D. D

“…Thrombospondin 1 (TSP1) is an angiogenesis inhibitor that decreases tumor growth. We now report that TSP1 directly inhibits the proliferation of human melanoma…”
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Regulation of Integrin Function by CD47 Ligands by Barazi, Heba O., Li, Zhuqing, Cashel, Jo Anne, Krutzsch, Henry C., Annis, Douglas S., Mosher, Deane F., Roberts, David D.

“…We examined the regulation of α 4 β 1 integrin function in melanoma cells and T cells by ligands of CD47. A CD47 antibody (B6H12) that inhibited α v β 3…”
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Myristyl Amino-Terminal Acylation of Murine Retrovirus Proteins: An Unusual Post-Translational Protein Modification by Henderson, Louis E., Krutzsch, Henry C., Oroszlan, Stephen

“…The primary structure of the NH2-terminal region of the gag gene encoded internal membrane-associated protein p15 has been determined for both Rauscher and…”
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Higher-order complex formation between the 72-kilodalton type IV collagenase and tissue inhibitor of metalloproteinases-2 by Kleiner, David E, Unsworth, Edward J, Krutzsch, Henry C, Stetler-Stevenson, William G

“…The collagenases are a class of matrix degradative enzymes whose actions are important in physiological and pathological processes. The human 72-kDa type IV…”
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