Search Results - "Kruth, H.S"

Apolipoprotein E Produced by Human Monocyte-derived Macrophages Mediates Cholesterol Efflux That Occurs in the Absence of Added Cholesterol Acceptors by Zhang, Wei-Yang, Gaynor, Paulette M., Kruth, Howard S.

“…Human monocyte-derived macrophages can efflux accumulated cholesterol without exogenously added cholesterol acceptors (Kruth, H. S., Skarlatos, S. I., Gaynor,…”
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Macrophage reversal of LDL aggregation by plasminogen activation by Kruth, H.S., Zhang, W.-Y., Ishii, I.

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Aggregated low density lipoprotein induces and enters surface-connected compartments of human monocyte-macrophages. Uptake occurs independently of the low density lipoprotein receptor by Zhang, W.Y, Gaynor, P.M, Kruth, H.S

“…Aggregation of low density lipoprotein (LDL) stimulates its uptake by macrophages. We have now shown by electron microscopic and chemical experiments that…”
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3.P.168 Aggregated LDL induces and enters surface-connected compartments of human monocyte-macrophages: A process independent of the LDL receptor by Kruth, H.S., Zhang, W.Y., Gaynor, P.M.

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Sequestration of acetylated LDL and cholesterol crystals by human monocyte-derived macrophages by Kruth, H.S. (National Institutes of Health, Bethesda, MD.), Skarlatos, S.I, Lilly, K, Chang, J, Ifrim, I

“…Monocyte-derived macrophages accumulate and process cholesterol in atherosclerotic lesions. Because of the importance of this process, we examined the…”
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Production of cholesterol-enriched nascent high density lipoproteins by human monocyte-derived macrophages is a mechanism that contributes to macrophage cholesterol efflux by Kruth, H S, Skarlatos, S I, Gaynor, P M, Gamble, W

“…Atherosclerotic lesions have a lipid core containing crystals and liposomes enriched in unesterified cholesterol as well as numerous monocyte-macrophages…”
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Apolipoprotein B Stimulates Formation of Monocyte-Macrophage Surface-connected Compartments and Mediates Uptake of Low Density Lipoprotein-derived Liposomes into these Compartments by Kruth, Howard S., Zhang, Wei-Yang, Skarlatos, Sonia I., Chao, Fei-Fei

“…Much of the cholesterol that accumulates in atherosclerotic plaques is found within monocyte-macrophages transforming these cells into “foam cells.” Native low…”
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130 MURINE BONE MARROW-DERIVED MACROPHAGES DIFFERENTIATED WITH GM-CSF BECOME FOAM CELLS BY PI 3-KINASE GAMMA-DEPENDENT FLUID-PHASE PINOCYTOSIS OF NATIVE LDL by Anzinger, J.J., Chang, J., Xu, Q., Bohnacker, T., Wymann, M.P., Kruth, H.S.

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A defect in cholesterol esterification in Niemann-Pick disease (type C) patients by Pentchev, Peter G., Comly, Marcella E., Kruth, Howard S., Vanier, Marie T., Wenger, David A., Patel, Shutish, Brady, Roscoe O.

“…The demonstration of a defect of cholesterol esterification in a mutant strain of BALB/c mice with an attendant reduction of sphingomyelinase activity…”
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Type-C Niemann-Pick Disease: Low Density Lipoprotein Uptake is Associated with Premature Cholesterol Accumulation in the Golgi Complex and Excessive Cholesterol Storage in Lysosomes by Blanchette-Mackie, E. Joan, Dwyer, Nancy K., Amende, Lynn M., Kruth, Howard S., Butler, Jean D., Sokol, Jacob, Comly, Marcella E., Vanier, Marie T., August, J. Thomas, Brady, Roscoe O., Pentchev, Peter G.

“…Incubation of fibroblasts derived from patients with type-C Niemann-Pick disease with low density lipoprotein results in excessive intracellular accumulation…”
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Hydrolysis of cholesteryl ester in low density lipoprotein converts this lipoprotein to a liposome by Chao, F F, Blanchette-Mackie, E J, Tertov, V V, Skarlatos, S I, Chen, Y J, Kruth, H S

“…Previously, we isolated and characterized unique liposomal-like, cholesterol-rich lipid particles that accumulate in human atherosclerotic lesions. Human…”
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Development of unesterified cholesterol-rich lipid particles in atherosclerotic lesions of WHHL and cholesterol-fed NZW rabbits by Chao, F.F, Blanchette-Mackie, E.J, Dickens, B.F, Gamble, W, Kruth, H.S

“…Previously, we isolated and characterized unesterified cholesterol-rich lipid particles (UCLP) that accumulate in extracellular spaces of atherosclerotic…”
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Subcellular localization and quantification of cholesterol in cultured human fibroblasts exposed to human low density lipoprotein by Kruth, H.S, Blanchette-Mackie, J, Avigan, J, Gamble, W, Vaughan, M

“…Subcellular localization of nonesterified cholesterol has been determined in normal human fibroblasts from cultures incubated with human low density…”
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2,4,5,2',4',5'-Hexachlorobiphenyl-lipoprotein (LDL, HDL, VLDL) interaction and induced lipidosis in cultured skin fibroblasts by Kling, D, Becker, M M, Kruth, H S, Gamble, W

“…2,4,5,2',4',5'-Hexachlorobiphenyl (HCB) induced cytoplasmic inclusions and lipidosis in normal ( AG1437 ) and hypercholesterolemic ( GM488 ) human skin…”
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Correlated analysis of cellular DNA, membrane antigens and light scatter of human lymphoid cells by Braylan, Raul C., Benson, Neal A., Nourse, Virginia, Kruth, Howard S.

“…Flow cytometric correlated analysis of membrane antigens, DNA, and light scatter was performed on human lymphoid cells using fluorescein (FITC)‐conjugated…”
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