Search Results - "Kruszewski, F H"

Regulation of intracellular free calcium in normal murine keratinocytes by Kruszewski, F H, Hennings, H, Yuspa, S H, Tucker, R W

“…Cultured normal murine keratinocytes maintain a basal cell phenotype in medium with a Ca2+ concentration of 0.05 mM and differentiate when exposed for 28-48 h…”
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Intracellular calcium alterations in response to increased external calcium in normal and neoplastic keratinocytes by Hennings, H, Kruszewski, F H, Yuspa, S H, Tucker, R W

“…Normal keratinocytes proliferate when cultured in medium with 0.02-0.10 mM calcium and terminally differentiate when medium calcium is increased to greater…”
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A comparison of three cytotoxicity endpoints in the corneal HCE-T model by CLOTHIER, R, ORME, A, WALKER, T. L, WARD, S. L, KRUSZEWSKI, F. H, DIPASQUALE, L. C, BROADHEAD, C. L

“…The prediction of ocular irritation potential from in vitro assays still presents a problem, despite a number of validation trials. A study with coded cosmetic…”
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Inhibition of chrysarobin skin tumor promotion in SENCAR mice by antioxidants by Battalora, M S, Kruszewski, F H, DiGiovanni, J

“…The present study was designed to further investigate the role of reactive oxygen species in the mechanism of action of anthrone tumor promoters. To accomplish…”
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Human corneal epithelial cultures and cell lines by Ward, S L, Walker, T L, Kruszewski, F H, DiPasquale, L C

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Alterations in epidermal polyamine levels and DNA synthesis following topical treatment with chrysarobin in SENCAR mice by KRUSZEWSKI, F. H, DIGIOVANNI, J

“…A single topical application of chrysarobin (220 nmol) to SENCAR mouse skin produced alterations in epidermal polyamine levels distinctly different from that…”
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Tumor progression in Sencar mouse skin as a function of initiator dose and promoter dose, duration, and type by EWING, M. W, CONTI, C. J, KRUSZEWSKI, F. H, SLAGA, T. J, DIGIOVANNI, J

“…The influence of initiator dose and promoter dose, duration, and type on the progression of papillomas to carcinomas was examined in Sencar mice. A good…”
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Characterization of skin tumor promotion and progression by chrysarobin in SENCAR mice by KRUSZEWSKI, F. H, CONTI, C. J, DIGIOVANNI, J

“…The characteristics of the skin tumor promotion response with anthrone derivatives has been further examined in SENCAR mice. Chrysarobin…”
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Differences in the regulation of intracellular calcium in normal and neoplastic keratinocytes are not caused by ras gene mutations by KRUSZEWSKI, F. H, HENNINGS, H, TUCKER, R. W, YUSPA, S. H

“…The development of resistance to terminal differentiation is an early event in epidermal neoplasia. Altered differentiation can be detected in vitro since…”
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Evaluation of a human corneal epithelial cell line as an in vitro model for assessing ocular irritation by KRUSZEWSKI, F. H, WALKER, T. L, DIPASQUALE, L. C

“…A human corneal epithelial cell line, 10.014 pRSV-T (HCR-T cells), has been used to develop a three-dimensional in vitro model of the human corneal epithelium…”
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Histologic Alterations Produced by Chrysarobin (1,8-dihydroxy-3-methyl-9-anthrone) in SENCAR Mouse Skin: Relationship to Skin Tumor Promoting Activity by Kruszewski, Francis H., Naito, Masashi, Naito, Yukiko, DiGiovanni, John

“…Histologic changes induced in SENCAR skin following a single treatment with chrysarobin (1,8-dihydroxy-3-methyl-9-anthrone) exhibited differences in time…”
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Structure-activity relationships for epidermal ornithine decarboxylase induction and skin tumor promotion by anthrones by DiGiovanni, J, Kruszewski, F H, Coombs, M M, Bhatt, T S, Pezeshk, A

“…The present study was designed to compare the skin tumor promoting and epidermal ornithine decarboxylase (ODC) inducing activities of various structural…”
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Modulation of chrysarobin skin tumor promotion by DiGiovanni, J, Kruszewski, F H, Chenicek, K J

“…The present study examined the effect of several prototypic inhibitors of phorbol ester skin tumor promotion on skin tumor promotion by chrysarobin, an…”
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Presence of a functionally altered ornithine decarboxylase activity in chrysarobin-promoted mouse epidermal papillomas by O'Brien, T G, O'Donnell, K, Kruszewski, F H, DiGiovanni, J

“…Recent work from this laboratory has demonstrated the presence of a structurally and functionally different ornithine decarboxylase (ODC) in mouse epidermal…”
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Effect of application frequency on epidermal ornithine decarboxylase induction by chrysarobin in SENCAR mice by Kruszewski, F H, Chenicek, K J, Digiovanni, J

“…Ornithine decarboxylase (ODC EC 4.1.1.17) induction in mouse epidermis after single or multiple topical applications of chrysarobin differed from that…”
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Other assays by Curren, R D, Sina, J F, Feder, P, Kruszewski, F H, Osborne, R, Regnier, J-F

“…As part of the Interagency Regulatory Alternatives Group (IRAG) program to evaluate the state of the art in the development of alternative (non-whole animal)…”
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Strontium induces murine keratinocyte differentiation in vitro in the presence of serum and calcium by Li, L, Kruszewski, F H, Punnonen, K, Tucker, R W, Yuspa, S H, Hennings, H

“…Primary mouse keratinocytes in culture are induced to terminally differentiate by increasing extracellular Ca2+ concentrations (Cao) from 0.05 mM to > or = 0.1…”
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IRAG Working Group 5: Other assays by Curren, R.D., Sina, J.F., Feder, P., Kruszewski, F.H., Osborne, R., Régnier, J.-F.

“…As part of the Interagency Regulatory Alternatives Group (IRAG) program to evaluate the state of the art in the development of alternative (non-whole animal)…”
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Proposed new classification scheme for chemical injury to the human eye by Bagley, Daniel M., Casterton, Phillip L., Dressler, William E., Edelhauser, Henry F., Kruszewski, Francis H., McCulley, James P., Nussenblatt, Robert B., Osborne, Rosemarie, Rothenstein, Arthur, Stitzel, Katherine A., Thomas, Karluss, Ward, Sherry L.

“…Various ocular alkali burn classification schemes have been published and used to grade human chemical eye injuries for the purpose of identifying treatments…”
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Kinetics of Haemophilus influenzae type B infection in normal and ribosome-immunized mice using intraperitoneal and intracerebral routes of inoculation by Burans, J P, Kruszewski, F H, Lynn, M, Solotorovsky, M

“…The kinetics of infection was studied in normal and ribosome-immunized mice challenged with Haemophilus influenzae Type b organisms. Ribosomal preparations…”
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