Search Results - "Kruse, Carol A"

Rasmussen's encephalitis: clinical features, pathobiology, and treatment advances by Varadkar, Sophia, Dr, Bien, Christian G, Prof, Kruse, Carol A, Prof, Jensen, Frances E, Prof, Bauer, Jan, Prof, Pardo, Carlos A, MD, Vincent, Angela, Prof, Mathern, Gary W, Prof, Cross, J Helen, Prof

“…Summary Rasmussen's encephalitis is a rare chronic neurological disorder, characterised by unilateral inflammation of the cerebral cortex, drug-resistant…”
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Retroviral replicating vector-mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity by Hiraoka, Kei, Inagaki, Akihito, Kato, Yuki, Huang, Tiffany T, Mitchell, Leah A, Kamijima, Shuichi, Takahashi, Masamichi, Matsumoto, Hiroshi, Hacke, Katrin, Kruse, Carol A, Ostertag, Derek, Robbins, Joan M, Gruber, Harry E, Jolly, Douglas J, Kasahara, Noriyuki

“…Prodrug-activator gene therapy with Toca 511, a tumor-selective retroviral replicating vector (RRV) encoding yeast cytosine deaminase, is being evaluated in…”
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Efficacy of systemic adoptive transfer immunotherapy targeting NY-ESO-1 for glioblastoma by Everson, Richard G, Antonios, Joseph P, Lisiero, Dominique N, Soto, Horacio, Scharnweber, Rudi, Garrett, Matthew C, Yong, William H, Li, Ning, Li, Gang, Kruse, Carol A, Liau, Linda M, Prins, Robert M

“…Immunotherapy is an ideal treatment modality to specifically target the diffusely infiltrative tumor cells of malignant gliomas while sparing the normal brain…”
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Antigenic Profiling of Glioma Cells to Generate Allogeneic Vaccines or Dendritic Cell–Based Therapeutics by JIAN GANG ZHANG, EGUCHI, Junichi, WEPSIC, H. Terry, OKADA, Hideho, JADUS, Martin R, KRUSE, Carol A, GOMEZ, German G, FAKHRAI, Habib, SCHROTER, Stephanie, WENXUE MA, HOA, Neil, MINEV, Boris, DELGADO, Christina

“…Purpose: Allogeneic glioma cell lines that are partially matched to the patient at class I human leukocyte antigen (HLA) loci and that display tumor-associated…”
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Cellular and vaccine therapeutic approaches for gliomas by Hickey, Michelle J, Malone, Colin C, Erickson, Kate L, Jadus, Martin R, Prins, Robert M, Liau, Linda M, Kruse, Carol A

“…Despite new additions to the standard of care therapy for high grade primary malignant brain tumors, the prognosis for patients with this disease is still…”
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Passive Immunotherapeutic Strategies for the Treatment of Malignant Gliomas by Nagasawa, Daniel T., MD, Fong, Christina, BS, Yew, Andrew, MD, Spasic, Marko, BA, Garcia, Heather M., BS, Kruse, Carol A., PhD, Yang, Isaac, MD

“…This review provides historical and recent perspectives related to passive immunotherapy for high-grade gliomas. The authors discuss approaches that use…”
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Temozolomide induces the expression of the glioma Big Potassium (gBK) ion channel, while inhibiting fascin-1 expression: possible targets for glioma therapy by Hoa, Neil T, Ge, Lisheng, Martini, Filippo, Chau, Vincent, Ahluwalia, Amrita, Kruse, Carol A, Jadus, Martin R

“…Temozolomide (TMZ) improves Glioblastoma Multiforme (GBM) patient survival. The invasive behavior of the glioma cells is the cause of GBM relapse. The glioma…”
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Evidence for the involvement of gamma delta T cells in the immune response in Rasmussen encephalitis by Owens, Geoffrey C, Erickson, Kate L, Malone, Colin C, Pan, Calvin, Huynh, My N, Chang, Julia W, Chirwa, Thabiso, Vinters, Harry V, Mathern, Gary W, Kruse, Carol A

“…Rasmussen encephalitis (RE) is a rare neuroinflammatory disease characterized by intractable seizures and progressive atrophy on one side of the cerebrum…”
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Differential expression of interferon-γ and chemokine genes distinguishes Rasmussen encephalitis from cortical dysplasia and provides evidence for an early Th1 immune response by Owens, Geoffrey C, Huynh, My N, Chang, Julia W, McArthur, David L, Hickey, Michelle J, Vinters, Harry V, Mathern, Gary W, Kruse, Carol A

“…Rasmussen encephalitis (RE) is a rare complex inflammatory disease, primarily seen in young children, that is characterized by severe partial seizures and…”
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Tumor antigen precursor protein profiles of adult and pediatric brain tumors identify potential targets for immunotherapy by Zhang, Jian Gang, Kruse, Carol A., Driggers, Lara, Hoa, Neil, Wisoff, Jeffrey, Allen, Jeffrey C., Zagzag, David, Newcomb, Elizabeth W., Jadus, Martin R.

“…Objectives We evaluated and compared tumor antigen precursor protein (TAPP) profiles in adult and pediatric brain tumors of 31 genes related to tumor…”
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Glioma big potassium channel expression in human cancers and possible T cell epitopes for their immunotherapy by Ge, Lisheng, Hoa, Neil T, Cornforth, Andrew N, Bota, Daniela A, Mai, Anthony, Kim, Dong In, Chiou, Shiun-Kwei, Hickey, Michelle J, Kruse, Carol A, Jadus, Martin R

“…Big potassium (BK) ion channels have several spliced variants. One spliced variant initially described within human glioma cells is the glioma BK (gBK)…”
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Fascin-1 knock-down of human glioma cells reduces their microvilli/filopodia while improving their susceptibility to lymphocyte-mediated cytotoxicity by Hoa, Neil T, Ge, Lisheng, Erickson, Kate L, Kruse, Carol A, Cornforth, Andrew N, Kuznetsov, Yurii, McPherson, Alex, Martini, Filippo, Jadus, Martin R

“…Cancer cells derived from Glioblastoma multiforme possess membranous protrusions allowing these cells to infiltrate surrounding tissue, while resisting…”
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Combined Alloreactive CTL Cellular Therapy with Prodrug Activator Gene Therapy in a Model of Breast Cancer Metastatic to the Brain by HICKEY, Michelle J, MALONE, Colin C, KASAHARA, Noriyuki, MUELLER, Barbara M, KRUSE, Carol A, ERICKSON, Kate L, LIN, Amy, SOTO, Horacio, HA, Edward T, KAMIJIMA, Shuichi, INAGAKI, Akihito, TAKAHASHI, Masamichi, KATO, Yuki

“…Individual or combined strategies of cellular therapy with alloreactive CTLs (alloCTL) and gene therapy using retroviral replicating vectors (RRV) encoding a…”
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Rasmussen encephalitis tissue transfer program by Kruse, Carol A., Pardo, Carlos A., Hartman, Adam L., Jallo, George, Vining, Eileen P. G., Voros, Joe, Gaillard, William D., Liu, Judy, Oluigbo, Chima, Malone, Stephen, Bleasel, Andrew F., Dexter, Mark, Micati, Alex, Velasco, Tonicarlo R., Machado, Helio R., Martino, Anthony M., Huang, Adam, Wheatley, B. M., Grant, Gerald A., Granata, Tiziana, Freri, Elena, Garbelli, Rita, Koh, Sookyong, Nordli, Douglas R., Campos, Alexandre R., O'Neill, Brent, Handler, Michael H., Chapman, Kevin E., Wilfong, Angus A., Curry, Daniel J., Yaun, Amanda, Madsen, Joseph R., Smyth, Matthew D., Mercer, Deanna, Bingaman, William, Harvey, A. S., Leventer, Richard J., Lockhart, Paul J., Gillies, Greta, Pope, Kate, Giller, Cole A., Park, Yong D., Rojiani, Amyn M., Sharma, Suash J., Jenkins, Patrick, Tung, Spencer, Huynh, My N., Chirwa, Thabiso W., Cepeda, Carlos, Levine, Michael S., Chang, Julia W., Owens, Geoffrey C., Vinters, Harry V., Mathern, Gary W.

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Combining cellular and gene therapy approaches for treatment of intracranial tumors by Hickey, Michelle J, Kasahara, Noriyuki, Mueller, Barbara M, Kruse, Carol A

“…New treatments are needed for brain metastasis, which is associated with high morbidity and mortality. Two novel cellular and gene therapy modalities were…”
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Small cell lung cancer cells express the late stage gBK tumor antigen: a possible immunotarget for the terminal disease by Hoa, Neil T, Ge, Lisheng, Tajhya, Rajeev B, Beeton, Christine, Cornforth, Andrew N, Abolhoda, Amir, Lambrecht, Nils, DaCosta-Iyer, Maria, Ouyang, Yi, Mai, Anthony P, Hong, Erin, Shon, Judy, Hickey, Michelle J, Erickson, Kate L, Kruse, Carol A, Jadus, Martin R

“…Big Potassium (BK) ion channels have several splice variants. One splice variant initially described within human glioma cells is called the glioma BK channel…”
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Cellular and functional characterization of immunoresistant human glioma cell clones selected with alloreactive cytotoxic t lymphocytes reveals their up-regulated synthesis of biologically active TGF-β by GOMEZ, German G, KRUSE, Carol A

“…Two immunoresistant (IR) glioma cell variants, 13-06-IR29 and 13-06-IR30, were cloned from 13-06-MG glioma cell populations after receiving continuous…”
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Reduced glioma infiltration in Src-deficient mice by LUND, Caren V, NGUYEN, Mai T. N, OWENS, Geoffrey C, PAKCHOIAN, Andrew J, SHATERIAN, Ashkaun, KRUSE, Carol A, ELICEIRI, Brian P

“…Malignant brain tumors, such as glioblastoma, are characterized by extensive angiogenesis and permeability of the blood-brain barrier (BBB). The infiltration…”
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Radial mobility and cytotoxic function of retroviral replicating vector transduced, non-adherent alloresponsive T lymphocytes by Erickson, Kate L, Hickey, Michelle J, Kato, Yuki, Malone, Colin C, Owens, Geoffrey C, Prins, Robert M, Liau, Linda M, Kasahara, Noriyuki, Kruse, Carol A

“…We report a novel adaptation of the Radial Monolayer Cell Migration assay, first reported to measure the radial migration of adherent tumor cells on…”
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FAPP2 gene downregulation increases tumor cell sensitivity to Fas-induced apoptosis by Tritz, Richard, Hickey, Michelle J., Lin, Amy H., Hadwiger, Philipp, Sah, Dinah W.Y., Neuwelt, Edward A., Mueller, Barbara M., Kruse, Carol A.

“…The gene for phosphatidylinositol-4-phosphate adaptor-2 (FAPP2) encodes a cytoplasmic lipid transferase with a plekstrin homology domain that has been…”
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