Search Results - "Krupitza Georg"

Initial steps of metastasis: Cell invasion and endothelial transmigration by van Zijl, Franziska, Krupitza, Georg, Mikulits, Wolfgang

“…Metastasis is the leading cause of cancer mortality. The metastatic cascade represents a multi-step process which includes local tumor cell invasion, entry…”
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Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT-mTOR-S6K signaling and drug responses by Riedl, Angelika, Schlederer, Michaela, Pudelko, Karoline, Stadler, Mira, Walter, Stefanie, Unterleuthner, Daniela, Unger, Christine, Kramer, Nina, Hengstschläger, Markus, Kenner, Lukas, Pfeiffer, Dagmar, Krupitza, Georg, Dolznig, Helmut

“…Three-dimensional (3D) cancer models are used as preclinical systems to mimic physiologic drug responses. We provide evidence for strong changes of…”
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The microRNA-200 family: still much to discover by Senfter Daniel, Madlener Sibylle, Krupitza Georg, Mader Robert M.

“…In the last decade, microRNAs (miRs or miRNAs) became of great interest in cancer research due to their multifunctional and active regulation in a variety of…”
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Isolation and NMR Scaling Factors for the Structure Determination of Lobatolide H, a Flexible Sesquiterpene from Neurolaena lobata by Kovács, Tibor, Lajter, Ildikó, Kúsz, Norbert, Schelz, Zsuzsanna, Bózsity-Faragó, Noémi, Borbás, Anikó, Zupkó, István, Krupitza, Georg, Frisch, Richard, Hohmann, Judit, Vasas, Andrea, Mándi, Attila

“…A new flexible germacranolide ( , lobatolide H) was isolated from the aerial parts of . The structure elucidation was performed by classical NMR experiments…”
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Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse by Kerjaschki, Dontscho, Bago-Horvath, Zsuzsanna, Rudas, Margaretha, Sexl, Veronika, Schneckenleithner, Christine, Wolbank, Susanne, Bartel, Gregor, Krieger, Sigurd, Kalt, Romana, Hantusch, Brigitte, Keller, Thomas, Nagy-Bojarszky, Katalin, Huttary, Nicole, Raab, Ingrid, Lackner, Karin, Krautgasser, Katharina, Schachner, Helga, Kaserer, Klaus, Rezar, Sandra, Madlener, Sybille, Vonach, Caroline, Davidovits, Agnes, Nosaka, Hitonari, Hämmerle, Monika, Viola, Katharina, Dolznig, Helmut, Schreiber, Martin, Nader, Alexander, Mikulits, Wolfgang, Gnant, Michael, Hirakawa, Satoshi, Detmar, Michael, Alitalo, Kari, Nijman, Sebastian, Offner, Felix, Maier, Thorsten J, Steinhilber, Dieter, Krupitza, Georg

“…In individuals with mammary carcinoma, the most relevant prognostic predictor of distant organ metastasis and clinical outcome is the status of axillary lymph…”
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Flavonoids Distinctly Stabilize Lymph Endothelial- or Blood Endothelial Disintegration Induced by Colon Cancer Spheroids SW620 by Berenda, Julia, Smöch, Claudia, Stadlbauer, Christa, Mittermair, Eva, Taxauer, Karin, Huttary, Nicole, Krupitza, Georg, Krenn, Liselotte

“…The health effects of plant phenolics in vegetables and other food and the increasing evidence of the preventive potential of flavonoids in "Western Diseases"…”
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Mesothelioma-associated fibroblasts enhance proliferation and migration of pleural mesothelioma cells via c-Met/PI3K and WNT signaling but do not protect against cisplatin by Ries, Alexander, Flehberger, Daniela, Slany, Astrid, Pirker, Christine, Mader, Johanna C, Mohr, Thomas, Schelch, Karin, Sinn, Katharina, Mosleh, Berta, Hoda, Mir Alireza, Dome, Balazs, Dolznig, Helmut, Krupitza, Georg, Müllauer, Leonhard, Gerner, Christopher, Berger, Walter, Grusch, Michael

“…Pleural mesothelioma (PM) is an aggressive malignancy with poor prognosis. Unlike many other cancers, PM is mostly characterized by inactivation of tumor…”
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Apigenin and Luteolin Attenuate the Breaching of MDA-MB231 Breast Cancer Spheroids Through the Lymph Endothelial Barrier in Vitro by Hong, Junli, Fristiohady, Adryan, Nguyen, Chi H, Milovanovic, Daniela, Huttary, Nicole, Krieger, Sigurd, Hong, Junqiang, Geleff, Silvana, Birner, Peter, Jäger, Walter, Özmen, Ali, Krenn, Liselotte, Krupitza, Georg

“…Flavonoids, present in fruits, vegetables and traditional medicinal plants, show anticancer effects in experimental systems and are reportedly non-toxic. This…”
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Antiproliferative and antimetastatic characterization of an exo-heterocyclic androstane derivative against human breast cancer cell lines by Kulmány, Ágnes E., Frank, Éva, Kovács, Dóra, Kirisits, Kerstin, Krupitza, Georg, Neuperger, Patrícia, Alföldi, Róbert, Puskás, László G., Szebeni, Gábor J., Zupkó, István

“…Cancer in general, and specifically gynaecological neoplasms, represents a major public health issue worldwide. Based on the effect of sex hormones on breast…”
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Colorectal cancer cell-derived microRNA200 modulates the resistance of adjacent blood endothelial barriers in vitro by Holzner, Silvio, Senfter, Daniel, Stadler, Serena, Staribacher, Anna, Nguyen, Chi Huu, Gaggl, Anna, Geleff, Silvana, Huttary, Nicole, Krieger, Sigurd, Jäger, Walter, Dolznig, Helmut, Mader, Robert M, Krupitza, Georg

“…Since cancer cells, when grown as spheroids, display drug sensitivity and radiation resistance patterns such as seen in vivo we recently established a…”
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Fibroblast growth factor receptor 4: a putative key driver for the aggressive phenotype of hepatocellular carcinoma by Gauglhofer, Christine, Paur, Jakob, Schrottmaier, Waltraud C, Wingelhofer, Bettina, Huber, Daniela, Naegelen, Isabelle, Pirker, Christine, Mohr, Thomas, Heinzle, Christine, Holzmann, Klaus, Marian, Brigitte, Schulte-Hermann, Rolf, Berger, Walter, Krupitza, Georg, Grusch, Michael, Grasl-Kraupp, Bettina

“…Recently, we found upregulation of fibroblast growth factor receptor 4 (FGFR4) in a subset of hepatocellular carcinoma (HCC). Here, we provide mechanistic…”
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Chemical Composition of Scrophularia lucida and the Effects on Tumor Invasiveness in Vitro by Lewenhofer, Verena, Schweighofer, Lisa, Ledermüller, Tobias, Eichsteininger, Julia, Kählig, Hanspeter, Zehl, Martin, Nguyen, Chi H, Krupitza, Georg, Özmen, Ali, Krenn, Liselotte

“…A detannified methanolic extract of L. attenuated the formation of cancer cell-induced circular chemorepellent induced defects (CCIDs) in the lymph endothelial…”
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Isolation, Structure Determination of Sesquiterpenes from Neurolaena lobata and Their Antiproliferative, Cell Cycle Arrest-Inducing and Anti-Invasive Properties against Human Cervical Tumor Cells by Vasas, Andrea, Lajter, Ildikó, Kúsz, Norbert, Király, Sándor Balázs, Kovács, Tibor, Kurtán, Tibor, Bózsity, Noémi, Nagy, Nikolett, Schelz, Zsuzsanna, Zupkó, István, Krupitza, Georg, Frisch, Richard, Mándi, Attila, Hohmann, Judit

“…Seven new germacranolides ( - , - ), among them a heterodimer ( ), and known germacranolide ( ), eudesmane ( ) and isodaucane ( ) sesquiterpenes were isolated…”
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Gallic acid inhibits ribonucleotide reductase and cyclooxygenases in human HL-60 promyelocytic leukemia cells by Madlener, Sibylle, Illmer, Christoph, Horvath, Zsuzsanna, Saiko, Philipp, Losert, Annemarie, Herbacek, Irene, Grusch, Michael, Elford, Howard L, Krupitza, Georg, Bernhaus, Astrid, Fritzer-Szekeres, Monika, Szekeres, Thomas

“…Abstract Gallic acid (GA) is a naturally occurring polyhydroxyphenolic compound and an excellent free radical scavenger. In this study, we examined its…”
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Altered expression of organic anion transporter polypeptide (OATP) genes in human breast carcinoma by Wlcek, Katrin, Svoboda, Martin, Sellner, Franz, Krupitza, Georg, Jaeger, Walter, Thalhammer, Theresia

“…Organic anion transporter polypeptides (OATPs) mediate the transmembrane uptake of endogenous compounds and clinically important drugs in various tissues…”
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Primary and hTERT-Transduced Mesothelioma-Associated Fibroblasts but Not Primary or hTERT-Transduced Mesothelial Cells Stimulate Growth of Human Mesothelioma Cells by Ries, Alexander, Slany, Astrid, Pirker, Christine, Mader, Johanna C, Mejri, Doris, Mohr, Thomas, Schelch, Karin, Flehberger, Daniela, Maach, Nadine, Hashim, Muhammad, Hoda, Mir Alireza, Dome, Balazs, Krupitza, Georg, Berger, Walter, Gerner, Christopher, Holzmann, Klaus, Grusch, Michael

“…Pleural mesothelioma (PM) is an aggressive malignancy that develops in a unique tumor microenvironment (TME). However, cell models for studying the TME in PM…”
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Structural Insight into the In Vitro Anti-Intravasative Properties of Flavonoids by Eichsteininger, Julia, Kirisits, Kerstin, Smöch, Claudia, Stadlbauer, Christa, Nguyen, Chi Huu, Jäger, Walter, Özmen, Ali, Ecker, Gerhard, Krupitza, Georg, Krenn, Liselotte

“…We investigated the effect of 21 flavonoids in a three-dimensional in vitro system for their ability to inhibit gap formation by MCF-7 breast cancer spheroids…”
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Comparison of cancer cells cultured in 2D vs 3D reveals differences in AKT/mTOR/S6-kinase signaling and drug response by Riedl, Angelika, Schlederer, Michaela, Pudelko, Karoline, Stadler, Mira, Walter, Stefanie, Unterleuthner, Daniela, Unger, Christine, Kramer, Nina, Hengstschläger, Markus, Kenner, Lukas, Pfeiffer, Dagmar, Krupitza, Georg, Dolznig, Helmut

“…3D cancer models are used as preclinical systems to mimic physiologic drug response. We provide evidence for robust changes of proliferation and metabolic…”
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Effects on inflammatory responses by the sphingoid base 4,8-sphingadienine by ROZEMA, EVELIEN, BINDER, MARKUS, BULUSU, MURTY, BOCHKOV, VALERY, KRUPITZA, GEORG, KOPP, BRIGITTE

“…Sphingolipids (SLs) are a class of lipids, which are structural cell components involved in the regulation of cellular processes such as cell proliferation,…”
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Characterization of Glucocerebrosides and the Active Metabolite 4,8-Sphingadienine from Arisaema amurense and Pinellia ternata by NMR and CD Spectroscopy and ESI-MS/CID-MS by Rozema, Evelien, Popescu, Ruxandra, Sonderegger, Harald, Huck, Christian W, Winkler, Johannes, Krupitza, Georg, Urban, Ernst, Kopp, Brigitte

“…Sphingolipid metabolites regulate cellular processes such as cell proliferation, differentiation, and apoptosis. In this study, glucocerebrosides (GluCer) from…”
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