Search Results - "Krupina, A. N."

Changes in Sociability and Preference for Social Novelty in Female Rats in Prolonged Social Isolation by Shirenova, S. D., Khlebnikova, N. N., Krupina, N. A.

“…Chronic stress due to social isolation (SI) can lead to distress with negative consequences for both humans and animals. Numerous disorders caused by SI…”
Get full text

Impaired Cognitive Functions in Prolonged Social Isolation: Results of Human Studies and Animal Experiments by Krupina, N. A., Shirenova, S. D.

“…Close social connections are essential for mental and physical health and well-being at any age. A significant proportion of the world’s population has…”
Get full text

Effect of Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Activity of Proline-Specific Peptidases in Brain Structures of Rats with Experimental MPTP-Induced Depressive Syndrome by Khlebnikova, N. N., Krupina, N. A., Bogdanova, N. G., Zolotov, N. N.

“…A noncompetitive synthetic inhibitor of prolyl endopeptidase benzyloxycarbonyl-methionyl- 2(S)-cyanopyrrolidine (1.0 mg/kg intraperitoneally for 2 weeks)…”
Get full text

Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine, a Prolyl Endopeptidase Inhibitor, Modulates Depression-Like Behavior of Rats in Forced Swimming Test and Activities of Proline-Specific Peptidases in the Brain Structures by Krupina, N. A., Bogdanova, N. G., Khlebnikova, N. N., Zolotov, N. N., Kryzhanovskii, G. N.

“…High activities of prolyl endopeptidase and dipeptidylpeptidase IV in the striatum and of prolyl endopeptidase in the frontal cortex were recorded in rats with…”
Get full text

Effect of Imipramine and Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Activity of Proline-Specific Peptidases in the Brain of Rats with Experimental Anxious-Depressive Syndrome by Khlebnikova, N. N., Krupina, N. A., Kushnareva, E. Yu, Zolotov, N. N., Kryzhanovskii, G. N.

“…Activities of prolyl endopeptidase and dipeptidyl peptidase IV in the frontal cortex, hypothalamus, nucleus accumbens, striatum, and hippocampus were measured…”
Get full text

Changes in the Ethogram in Rats Due to Contagion Behavior by Ivanov, D. G., Krupina, N. A.

“…Experiments were performed using a model of contagion behavior based on drinking behavior in rats. Observer rats without the drinking motivation, in the…”
Get full text

The Levels of Monoamines and Their Metabolites in the Brain Structures of Rats Subjected to Two- and Three-Month-Long Social Isolation by Krupina, N. A., Khlebnikova, N. N., Narkevich, V. B., Naplekova, P. L., Kudrin, V. S.

“…The levels of monoamines and their metabolites in the brain structures of adult Wistar rats subjected to post-weaning social isolation for 2 and 3 months were…”
Get full text

Behavioral Changes in Rats Induced by a Dipeptidyl Peptidase IV Inhibitor Methionyl-2(S)-Cyanopyrrolidine: Experimental Model of Anxiety-Depression Disorder by Krupina, N. A, Kushnareva, E. Yu, Khlebnikova, N. N, Zolotov, N. N, Kryzhanovskii, G. N

“…Administration of a synthetic dipeptidyl peptidase IV inhibitor methionyl-2(S)-cyanopyrrolidine (1 mg/kg) to rats during the early postnatal period was…”
Get full text

Experimental Model of Combined Pain and Depression Status in Rats by Krupina, N. A, Khlebnikova, N. N, Orlova, I. N, Grafova, V. N, Smirnova, V. S, Rodina, V. I, Kukushkin, M. L, Kryzhanovsky, G. N

“…Combined pain and depression status in rats was created by inducing experimental depressive syndrome (by subchronic injection of MPTP proneurotoxin) in animals…”
Get full text

Activities of Proline-Specific Peptidases in Brain Structures of Rats with Experimental Anxiety-Depressive State Caused by Administration of Dipeptidyl Peptidase IV Inhibitor in the Early Postnatal Period by Kushnareva, E. Yu, Krupina, N. A., Khlebnikova, N. N., Zolotov, N. N., Kryzhanovskii, G. N.

“…We studied the dynamics of activity of dipeptidyl peptidase IV (DP-IV) and prolyl endopeptidase (PEP) in the frontal cortex, hypothalamus, striatum, nucleus…”
Get full text

The Effect of Aqueous Solution of Silver Nanoparticles on Rat Behavior by Egorova, E M, Krupina, N A, Kaba, S I, Khlebnikova, N N, Shirenova, S D, Sviridkina, N B, Paltsyn, A A

“…Silver nanoparticles (AgNP) are known to penetrate the brain and cause pathological changes in central nervous system (CNS) functions. Still, it remains…”
Get full text

Post-Weaning Social Isolation Disturbs Gene Expression in Rat Brain Structures by Zubkov, E. A., Zorkina, Ya. A., Orshanskaya, E. V., Khlebnikova, N. N., Krupina, N. A., Chekhonin, V. P.

“…Post-weaning social isolation of male Wistar rats for 10 weeks led to an increase of their aggressiveness, sensorimotor reactivity, and cognitive deficiency,…”
Get full text

Effects of Prolylendopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Experimental Depressive Syndrome Development in Rats by Khlebnikova, N. N., Krupina, N. A., Bogdanova, N. G., Zolotov, N. N., Kryzhanovskii, G. N.

“…Model of experimental depressive syndrome in rats induced by repeated systemic injection of proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine showed…”
Get full text

Emotional Motivational Disorders in Rats as a Result of Diprotin A and Sitagliptin Administration in the First Postnatal Week by Krupina, N A, Khlebnikova, N N, Orlova, I N

“…The inhibitors of proline specific peptidase dipeptidyl peptidase-IV (DPP-IV, CD 26; EC 3.4.14.5) diprotin A (2 mg/kg) and sitagliptin (4 mg/kg) upon daily…”
Get more information

Dipeptidyl Peptidase 4 Inhibitors Diprotin A and Sitagliptin Administered on Weeks 2-3 of Postnatal Development Modulate Monoamine Metabolism in the Striatum of Adult Rats by Khlebnikova, N. N., Orshanskaya, E. V., Narkevich, V. B., Kudrin, V. S., Krupina, N. A.

“…The levels of monoamines and their metabolites in brain structures of adult (3-month-old) rats with emotional and motivational disorders induced by inhibitors…”
Get full text

Involvement of brain dopaminergic systems in the development of an MPTP-induced depressive state in rats by Pankova, N. B., Krupina, N. A., Orlova, I. N., Khlebnikova, N. N., Kryzhanovskii, G. N.

“…A depressive state was induced in Wistar rats by repeated i.p. injections of the proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which…”
Get full text

Early social isolation increases aggression and impairs a short-term habituation in acoustic startle reflex in rats by Krupina, N A, Khlebnikova, N N, Orlova, I N

“…Prolonged social isolation in early ontogeny leads to various changes in behavior and cognitive dysfunction in adult rats; however, data on the disorders are…”
Get more information

Activities of prolyl endopeptidase and dipeptidyl peptidase IV in brain structures of rats with dopamine deficiency-dependent MPTP-induced depressive syndrome by Krupina, N A, Zolotov, N N, Bogdanova, N G, Orlova, I N, Khlebnikova, N N, Kryzhanovskii, G N

“…The development of MPTP-induced depressive syndrome in rats was accompanied by activation of prolyl endopeptidase and dipeptidyl peptidase IV in the brain…”
Get full text

Inflammatory bowel disease with a very early onset by Kornienko, E. A., Krupina, A. N., Gabrusskaya, T. V., Kalinina, N. M.

“…Inflammatory bowel disease (Crohn's disease and ulcerative colitis) has a tendency to manifest at earlier age. In childhood (< 6 years of age) it has an…”
Get full text

The contagious behavior model on the basis of rat drinking behavior by Ivanov, D G, Semenov, A N, Krupina, N A

“…In work, the attempt of contagious behavior modeling on the basis of rat drinking behavior was made. Rats' behavior was observed in home cage with two bottles…”
Get more information