Search Results - "Krungkrai, J"

The multiple roles of the mitochondrion of the malarial parasite by Krungkrai, J

“…Mitochondria of the malaria parasite Plasmodium falciparum are morphologically different between the asexual and sexual blood stages (gametocytes). In this…”
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Structural Basis for the Decarboxylation of Orotidine 5'-Monophosphate (OMP) by Plasmodium Falciparum OMP Decarboxylase by Tokuoka, Keiji, Kusakari, Yukiko, Krungkrai, Sudaratana R, Matsumura, Hiroyoshi, Kai, Yasushi, Krungkrai, Jerapan, Horii, Toshihiro, Inoue, Tsuyoshi

“…Orotidine 5'-monophoshate decarboxylase (OMPDC) catalyses the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). Here, we…”
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Ultrastructure and function of mitochondria in gametocytic stage of Plasmodium falciparum by Krungkrai, J, Prapunwattana, P, Krungkrai, S R

“…Morphological properties of the mitochondrial organelles in the asexual and sexual gametocytic stages of Plasmodium falciparum have been analyzed and found to…”
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Mitochondrial cytochrome b gene in two developmental stages of human malarial parasite Plasmodium falciparum by Petmitr, S, Krungkrai, J

“…The cytochrome b gene of the mitochondrial ubiquinol-cytochrome c reductase (complex III of electron transport chain) was characterized in two developmental…”
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Plasmodium berghei: partial purification and characterization of the mitochondrial cytochrome c oxidase by Krungkrai, J, Krungkrai, S R, Bhumiratana, A

“…Mitochondria from a rodent malarial parasite (Plasmodium berghei) were successfully purified by differential centrifugation and 22% Percoll density gradient…”
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Kinetic benefits and thermal stability of orotate phosphoribosyltransferase and orotidine 5′-monophosphate decarboxylase enzyme complex in human malaria parasite Plasmodium falciparum by Kanchanaphum, Panan, Krungkrai, Jerapan

“…We have previously shown that orotate phosphoribosyltransferase (OPRT) and orotidine 5′-monophosphate decarboxylase (OMPDC) in human malaria parasite…”
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Malaria parasite carbonic anhydrase:inhibition of aromatic/heterocyclic sulfonamides and its therapeutic potential by Krungkrai, Sudaratana R, Krungkrai, Jerapan

“…Plasmodium falciparum（P.falciparum） is responsible for the majority of life-threatening cases of human malaria,causing 1.5-2.7 million annual deaths.The global…”
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Carbonic anhydrase inhibitors. Inhibition of Plasmodium falciparum carbonic anhydrase with aromatic sulfonamides: towards antimalarials with a novel mechanism of action? by Krungkrai, Jerapan, Scozzafava, Andrea, Reungprapavut, Sutarnthip, Krungkrai, Sudaratana R., Rattanajak, Roonglawan, Kamchonwongpaisan, Sumalee, Supuran, Claudiu T.

“…[Display omitted] The malarial parasite Plasmodium falciparum encodes for an α-carbonic anhydrase (CA) enzyme possessing catalytic properties distinct of that…”
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Malarial dihydroorotate dehydrogenase mediates superoxide radical production by Krungkrai, J

“…Dihydroorotate dehydrogenase purified from mitochondria of Plasmodium berghei, a rodent malaria parasite, mediates production of superoxide radical during…”
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Dihydroorotase of human malarial parasite Plasmodium falciparum differs from host enzyme by Krungkrai, Sudaratana R., Wutipraditkul, Nuchanat, Krungkrai, Jerapan

“…Plasmodium falciparum, the causative agent of human malaria, is totally dependent on de novo pyrimidine biosynthetic pathway. A gene encoding P. falciparum…”
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Purification, characterization and localization of mitochondrial dihydroorotate dehydrogenase in Plasmodium falciparum, human malaria parasite by Krungkrai, Jerapan

“…The mitochondrial dihydroorotate dehydrogenase (DHODase), the single redox reaction in the pyrimidine de novo synthetic pathway, was purified to near…”
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A Novel Enzyme Complex of Orotate Phosphoribosyltransferase and Orotidine 5‘-Monophosphate Decarboxylase in Human Malaria Parasite Plasmodium falciparum:  Physical Association, Kinetics, and Inhibition Characterization by Krungkrai, Sudaratana R, DelFraino, Brian J, Smiley, Jeffrey A, Prapunwattana, Phisit, Mitamura, Toshihide, Horii, Toshihiro, Krungkrai, Jerapan

“…Human malaria parasite, Plasmodium falciparum, can only synthesize pyrimidine nucleotides using the de novo pathway, whereas mammalian cells obtain pyrimidine…”
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Antimalarial naphthoquinones from Nepenthes thorelii by Likhitwitayawuid, K, Kaewamatawong, R, Ruangrungsi, N, Krungkrai, J

“…Roots of Nepenthes thorelii yielded plumbagin, 2-methylnaphthazarin, octadecyl caffeate, isoshinanolone, and droserone. In addition, seven derivatives were…”
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Enhanced Ca2+ uptake by mouse erythrocytes in malarial (Plasmodium berghei) infection by Krungkrai, J, Yuthavong, Y

“…Erythrocytes from Plasmodium berghei-infected mice on incubation either in plasma or artificial isotonic media showed an increase in uptake of 45Ca2+ compared…”
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Plasmodium falciparum carbonic anhydrase is a possible target for malaria chemotherapy by Reungprapavut, Sutarnthip, Krungkrai, Sudaratana R, Krungkrai, Jerapan

“…Plasmodiumfalciparum is responsible for the majority of life-threatening cases of human malaria. The global emergence of drug-resistant malarial parasites…”
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Orotate phosphoribosyltransferase and orotidine 5 ′-monophosphate decarboxylase exist as multienzyme complex in human malaria parasite Plasmodium falciparum by Krungkrai, Sudaratana R, Prapunwattana, Phisit, Horii, Toshihiro, Krungkrai, Jerapan

“…Plasmodium falciparum, the causative agent of the most lethal form of human malaria, totally depends on de novo pyrimidine biosynthetic pathway. Orotate…”
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Characterisation of carbonic anhydrase in Plasmodium falciparum by Krungkrai, Sudaratana R, Suraveratum, Nongluk, Rochanakij, Sunant, Krungkrai, Jerapan

“…Here we report the existence, purification and characterisation of carbonic anhydrase in Plasmodium falciparum. The infected red cells contained carbonic…”
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Antimalarial xanthones from Garcinia cowa by Likhitwitayawuid, K, Phadungcharoen, T, Krungkrai, J

“…Five xanthones from the bark of Garcinia cowa, namely 7-O-methylgarcinone E (1), cowanin (2), cowanol (3), cowaxanthone (4), and beta-mangostin (5), were found…”
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Orotate phosphoribosyltransferase and orotidine 5 super()-monophosphate decarboxylase exist as multienzyme complex in human malaria parasite Plasmodium falciparum by Krungkrai, SR, Prapunwattana, P, Horii, T, Krungkrai, J

“…Plasmodium falciparum, the causative agent of the most lethal form of human malaria, totally depends on de novo pyrimidine biosynthetic pathway. Orotate…”
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Human malaria parasite orotate phosphoribosyltransferase: functional expression, characterization of kinetic reaction mechanism and inhibition profile by Krungkrai, Sudaratana R, Aoki, Sayaka, Palacpac, Nirianne Marie Q, Sato, Dan, Mitamura, Toshihide, Krungkrai, Jerapan, Horii, Toshihiro

“…Plasmodium falciparum, the causative agent of the most lethal form of human malaria, relies on de novo pyrimidine biosynthesis. A gene encoding orotate…”
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