Search Results - "Krumsiek, Jan"

Multi-omics integration in biomedical research – A metabolomics-centric review by Wörheide, Maria A., Krumsiek, Jan, Kastenmüller, Gabi, Arnold, Matthias

“…Recent advances in high-throughput technologies have enabled the profiling of multiple layers of a biological system, including DNA sequence data (genomics),…”
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Gepard: a rapid and sensitive tool for creating dotplots on genome scale by Krumsiek, Jan, Arnold, Roland, Rattei, Thomas

“…Gepard provides a user-friendly, interactive application for the quick creation of dotplots. It utilizes suffix arrays to reduce the time complexity of dotplot…”
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Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome by Arnold, Matthias, Nho, Kwangsik, Kueider-Paisley, Alexandra, Massaro, Tyler, Huynh, Kevin, Brauner, Barbara, MahmoudianDehkordi, Siamak, Louie, Gregory, Moseley, M. Arthur, Thompson, J. Will, John-Williams, Lisa St, Tenenbaum, Jessica D., Blach, Colette, Chang, Rui, Brinton, Roberta D., Baillie, Rebecca, Han, Xianlin, Trojanowski, John Q., Shaw, Leslie M., Martins, Ralph, Weiner, Michael W., Trushina, Eugenia, Toledo, Jon B., Meikle, Peter J., Bennett, David A., Krumsiek, Jan, Doraiswamy, P. Murali, Saykin, Andrew J., Kaddurah-Daouk, Rima, Kastenmüller, Gabi

“…Late-onset Alzheimer’s disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex and APOE ε4 genotype represent strong risk factors…”
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The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice by Kindt, Alida, Liebisch, Gerhard, Clavel, Thomas, Haller, Dirk, Hörmannsperger, Gabriele, Yoon, Hongsup, Kolmeder, Daniela, Sigruener, Alexander, Krautbauer, Sabrina, Seeliger, Claudine, Ganzha, Alexandra, Schweizer, Sabine, Morisset, Rosalie, Strowig, Till, Daniel, Hannelore, Helm, Dominic, Küster, Bernhard, Krumsiek, Jan, Ecker, Josef

“…Interactions between the gut microbial ecosystem and host lipid homeostasis are highly relevant to host physiology and metabolic diseases. We present a…”
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Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans by Sachs, Stephan, Zarini, Simona, Kahn, Darcy E, Harrison, Kathleen A, Perreault, Leigh, Phang, Tzu, Newsom, Sean A, Strauss, Allison, Kerege, Anna, Schoen, Jonathan A, Bessesen, Daniel H, Schwarzmayr, Thomas, Graf, Elisabeth, Lutter, Dominik, Krumsiek, Jan, Hofmann, Susanna M, Bergman, Bryan C

“…Intermuscular adipose tissue (IMAT) is negatively related to insulin sensitivity, but a causal role of IMAT in the development of insulin resistance is…”
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Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies by Do, Kieu Trinh, Wahl, Simone, Raffler, Johannes, Molnos, Sophie, Laimighofer, Michael, Adamski, Jerzy, Suhre, Karsten, Strauch, Konstantin, Peters, Annette, Gieger, Christian, Langenberg, Claudia, Stewart, Isobel D., Theis, Fabian J., Grallert, Harald, Kastenmüller, Gabi, Krumsiek, Jan

“…Background Untargeted mass spectrometry (MS)-based metabolomics data often contain missing values that reduce statistical power and can introduce bias in…”
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Statistical methods for the analysis of high-throughput metabolomics data by Bartel, Jörg, Krumsiek, Jan, Theis, Fabian J

“…Metabolomics is a relatively new high-throughput technology that aims at measuring all endogenous metabolites within a biological sample in an unbiased…”
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Hierarchical differentiation of myeloid progenitors is encoded in the transcription factor network by Krumsiek, Jan, Marr, Carsten, Schroeder, Timm, Theis, Fabian J

“…Hematopoiesis is an ideal model system for stem cell biology with advanced experimental access. A systems view on the interactions of core transcription…”
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Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data by Krumsiek, Jan, Suhre, Karsten, Illig, Thomas, Adamski, Jerzy, Theis, Fabian J

“…With the advent of high-throughput targeted metabolic profiling techniques, the question of how to interpret and analyze the resulting vast amount of data…”
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A metabolome-wide association study in the general population reveals decreased levels of serum laurylcarnitine in people with depression by Zacharias, Helena U., Hertel, Johannes, Johar, Hamimatunnisa, Pietzner, Maik, Lukaschek, Karoline, Atasoy, Seryan, Kunze, Sonja, Völzke, Henry, Nauck, Matthias, Friedrich, Nele, Kastenmüller, Gabi, Grabe, Hans J., Gieger, Christian, Krumsiek, Jan, Ladwig, Karl-Heinz

“…Depression constitutes a leading cause of disability worldwide. Despite extensive research on its interaction with psychobiological factors, associated…”
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A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population by Sekula, Peggy, Goek, Oemer-Necmi, Quaye, Lydia, Barrios, Clara, Levey, Andrew S, Römisch-Margl, Werner, Menni, Cristina, Yet, Idil, Gieger, Christian, Inker, Lesley A, Adamski, Jerzy, Gronwald, Wolfram, Illig, Thomas, Dettmer, Katja, Krumsiek, Jan, Oefner, Peter J, Valdes, Ana M, Meisinger, Christa, Coresh, Josef, Spector, Tim D, Mohney, Robert P, Suhre, Karsten, Kastenmüller, Gabi, Köttgen, Anna

“…Small molecules are extensively metabolized and cleared by the kidney. Changes in serum metabolite concentrations may result from impaired kidney function and…”
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Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children by Bonifacio, Ezio, Beyerlein, Andreas, Hippich, Markus, Winkler, Christiane, Vehik, Kendra, Weedon, Michael N, Laimighofer, Michael, Hattersley, Andrew T, Krumsiek, Jan, Frohnert, Brigitte I, Steck, Andrea K, Hagopian, William A, Krischer, Jeffrey P, Lernmark, Åke, Rewers, Marian J, She, Jin-Xiong, Toppari, Jorma, Akolkar, Beena, Oram, Richard A, Rich, Stephen S, Ziegler, Anette-G

“…Around 0.3% of newborns will develop autoimmunity to pancreatic beta cells in childhood and subsequently develop type 1 diabetes before adulthood. Primary…”
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Software tools for single-cell tracking and quantification of cellular and molecular properties by Hilsenbeck, Oliver, Schwarzfischer, Michael, Skylaki, Stavroula, Schauberger, Bernhard, Hoppe, Philipp S, Loeffler, Dirk, Kokkaliaris, Konstantinos D, Hastreiter, Simon, Skylaki, Eleni, Filipczyk, Adam, Strasser, Michael, Buggenthin, Felix, Feigelman, Justin S, Krumsiek, Jan, van den Berg, Adrianus J J, Endele, Max, Etzrodt, Martin, Marr, Carsten, Theis, Fabian J, Schroeder, Timm

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Discovery of sexual dimorphisms in metabolic and genetic biomarkers by Mittelstrass, Kirstin, Ried, Janina S, Yu, Zhonghao, Krumsiek, Jan, Gieger, Christian, Prehn, Cornelia, Roemisch-Margl, Werner, Polonikov, Alexey, Peters, Annette, Theis, Fabian J, Meitinger, Thomas, Kronenberg, Florian, Weidinger, Stephan, Wichmann, Heinz Erich, Suhre, Karsten, Wang-Sattler, Rui, Adamski, Jerzy, Illig, Thomas

“…Metabolomic profiling and the integration of whole-genome genetic association data has proven to be a powerful tool to comprehensively explore gene regulatory…”
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Gender-specific pathway differences in the human serum metabolome by Krumsiek, Jan, Mittelstrass, Kirstin, Do, Kieu Trinh, Stückler, Ferdinand, Ried, Janina, Adamski, Jerzy, Peters, Annette, Illig, Thomas, Kronenberg, Florian, Friedrich, Nele, Nauck, Matthias, Pietzner, Maik, Mook-Kanamori, Dennis O., Suhre, Karsten, Gieger, Christian, Grallert, Harald, Theis, Fabian J., Kastenmüller, Gabi

“…The susceptibility for various diseases as well as the response to treatments differ considerably between men and women. As a basis for a gender-specific…”
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The dynamic range of the human metabolome revealed by challenges by Krug, Susanne, Kastenmüller, Gabi, Stückler, Ferdinand, Rist, Manuela J., Skurk, Thomas, Sailer, Manuela, Raffler, Johannes, Römisch‐Margl, Werner, Adamski, Jerzy, Prehn, Cornelia, Frank, Thomas, Engel, Karl‐Heinz, Hofmann, Thomas, Luy, Burkhard, Zimmermann, Ralf, Moritz, Franco, Schmitt‐Kopplin, Philippe, Krumsiek, Jan, Kremer, Werner, Huber, Fritz, Oeh, Uwe, Theis, Fabian J., Szymczak, Wilfried, Hauner, Hans, Suhre, Karsten, Daniel, Hannelore

“…Metabolic challenge protocols, such as the oral glucose tolerance test, can uncover early alterations in metabolism preceding chronic diseases. Nevertheless,…”
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The Human Blood Metabolome-Transcriptome Interface by Bartel, Jörg, Krumsiek, Jan, Schramm, Katharina, Adamski, Jerzy, Gieger, Christian, Herder, Christian, Carstensen, Maren, Peters, Annette, Rathmann, Wolfgang, Roden, Michael, Strauch, Konstantin, Suhre, Karsten, Kastenmüller, Gabi, Prokisch, Holger, Theis, Fabian J

“…Biological systems consist of multiple organizational levels all densely interacting with each other to ensure function and flexibility of the system…”
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Multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDS by Batra, Richa, Whalen, William, Alvarez-Mulett, Sergio, Gomez-Escobar, Luis G, Hoffman, Katherine L, Simmons, Will, Harrington, John, Chetnik, Kelsey, Buyukozkan, Mustafa, Benedetti, Elisa, Choi, Mary E, Suhre, Karsten, Schenck, Edward, Choi, Augustine M K, Schmidt, Frank, Cho, Soo Jung, Krumsiek, Jan

“…Acute respiratory distress syndrome (ARDS), a life-threatening condition characterized by hypoxemia and poor lung compliance, is associated with high…”
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Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight by Houerbi, Nadia, Kim, JangKeun, Overbey, Eliah G., Batra, Richa, Schweickart, Annalise, Patras, Laura, Lucotti, Serena, Ryon, Krista A., Najjar, Deena, Meydan, Cem, Damle, Namita, Chin, Christopher, Narayanan, S. Anand, Guarnieri, Joseph W., Widjaja, Gabrielle, Beheshti, Afshin, Tobias, Gabriel, Vatter, Fanny, Hirschberg, Jeremy Wain, Kleinman, Ashley, Afshin, Evan E., MacKay, Matthew, Chen, Qiuying, Miller, Dawson, Gajadhar, Aaron S., Williamson, Lucy, Tandel, Purvi, Yang, Qiu, Chu, Jessica, Benz, Ryan, Siddiqui, Asim, Hornburg, Daniel, Gross, Steven, Shirah, Bader, Krumsiek, Jan, Mateus, Jaime, Mao, Xiao, Matei, Irina, Mason, Christopher E.

“…As spaceflight becomes more common with commercial crews, blood-based measures of crew health can guide both astronaut biomedicine and countermeasures. By…”
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Odefy--from discrete to continuous models by Krumsiek, Jan, Pölsterl, Sebastian, Wittmann, Dominik M, Theis, Fabian J

“…Phenomenological information about regulatory interactions is frequently available and can be readily converted to Boolean models. Fully quantitative models,…”
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