Search Results - "Krumm, Stefanie A"

Glycan clustering stabilizes the mannose patch of HIV-1 and preserves vulnerability to broadly neutralizing antibodies by Pritchard, Laura K., Spencer, Daniel I.R., Royle, Louise, Bonomelli, Camille, Seabright, Gemma E., Behrens, Anna-Janina, Kulp, Daniel W., Menis, Sergey, Krumm, Stefanie A., Dunlop, D. Cameron, Crispin, Daniel J., Bowden, Thomas A., Scanlan, Christopher N., Ward, Andrew B., Schief, William R., Doores, Katie J., Crispin, Max

“…The envelope spike of HIV-1 employs a ‘glycan shield’ to protect itself from antibody-mediated neutralization. Paradoxically, however, potent broadly…”
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HIV-1 Glycan Density Drives the Persistence of the Mannose Patch within an Infected Individual by Coss, Karen P, Vasiljevic, Snezana, Pritchard, Laura K, Krumm, Stefanie A, Glaze, Molly, Madzorera, Sharon, Moore, Penny L, Crispin, Max, Doores, Katie J

“…The HIV envelope glycoprotein (Env) is extensively modified with host-derived N-linked glycans. The high density of glycosylation on the viral spike limits…”
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The Measles Virus Nucleocapsid Protein Tail Domain Is Dispensable for Viral Polymerase Recruitment and Activity by Krumm, Stefanie A., Takeda, Makoto, Plemper, Richard K.

“…Paramyxovirus genomes are ribonucleoprotein (RNP) complexes consisting of nucleoprotein (N)-encapsidated viral RNA. Measles virus (MeV) N features an…”
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A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus by Allen, Elizabeth R., Krumm, Stefanie A., Raghwani, Jayna, Halldorsson, Steinar, Elliott, Angela, Graham, Victoria A., Koudriakova, Elina, Harlos, Karl, Wright, Daniel, Warimwe, George M., Brennan, Benjamin, Huiskonen, Juha T., Dowall, Stuart D., Elliott, Richard M., Pybus, Oliver G., Burton, Dennis R., Hewson, Roger, Doores, Katie J., Bowden, Thomas A.

“…The Gn subcomponent of the Gn-Gc assembly that envelopes the human and animal pathogen, Rift Valley fever virus (RVFV), is a primary target of the neutralizing…”
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Contrasting Modes of New World Arenavirus Neutralization by Immunization-Elicited Monoclonal Antibodies by Ng, Weng M, Sahin, Mehmet, Krumm, Stefanie A, Seow, Jeffrey, Zeltina, Antra, Harlos, Karl, Paesen, Guido C, Pinschewer, Daniel D, Doores, Katie J, Bowden, Thomas A

“…Transmission of the New World hemorrhagic fever arenaviruses Junín virus (JUNV) and Machupo virus (MACV) to humans is facilitated, in part, by the interaction…”
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Structural Basis for a Neutralizing Antibody Response Elicited by a Recombinant Hantaan Virus Gn Immunogen by Rissanen, Ilona, Krumm, Stefanie A, Stass, Robert, Whitaker, Annalis, Voss, James E, Bruce, Emily A, Rothenberger, Sylvia, Kunz, Stefan, Burton, Dennis R, Huiskonen, Juha T, Botten, Jason W, Bowden, Thomas A, Doores, Katie J

“…Hantaviruses are a group of emerging pathogens capable of causing severe disease upon zoonotic transmission to humans. The mature hantavirus surface presents…”
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Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein by Rissanen, Ilona, Stass, Robert, Krumm, Stefanie A, Seow, Jeffrey, Hulswit, Ruben Jg, Paesen, Guido C, Hepojoki, Jussi, Vapalahti, Olli, Lundkvist, Åke, Reynard, Olivier, Volchkov, Viktor, Doores, Katie J, Huiskonen, Juha T, Bowden, Thomas A

“…The intricate lattice of Gn and Gc glycoprotein spike complexes on the hantavirus envelope facilitates host-cell entry and is the primary target of the…”
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EGFR Interacts with the Fusion Protein of Respiratory Syncytial Virus Strain 2-20 and Mediates Infection and Mucin Expression by Currier, Michael G, Lee, Sujin, Stobart, Christopher C, Hotard, Anne L, Villenave, Remi, Meng, Jia, Pretto, Carla D, Shields, Michael D, Nguyen, Minh Trang, Todd, Sean O, Chi, Michael H, Hammonds, Jason, Krumm, Stefanie A, Spearman, Paul, Plemper, Richard K, Sakamoto, Kaori, Peebles, Jr, R Stokes, Power, Ultan F, Moore, Martin L

“…Respiratory syncytial virus (RSV) is the major cause of viral lower respiratory tract illness in children. In contrast to the RSV prototypic strain A2,…”
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Probing the Spatial Organization of Measles Virus Fusion Complexes by PAAL, Tanja, BRINDLEY, Melinda A, CLAIR, Courtney St, PRUSSIA, Andrew, GAUS, Dominika, KRUMM, Stefanie A, SNYDER, James P, PLEMPER, Richard K

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Potent host-directed small-molecule inhibitors of myxovirus RNA-dependent RNA-polymerases by Krumm, Stefanie A, Ndungu, J Maina, Yoon, Jeong-Joong, Dochow, Melanie, Sun, Aiming, Natchus, Michael, Snyder, James P, Plemper, Richard K

“…Therapeutic targeting of host cell factors required for virus replication rather than of pathogen components opens new perspectives to counteract virus…”
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Dual Myxovirus Screen Identifies a Small-Molecule Agonist of the Host Antiviral Response by Yan, Dan, Krumm, Stefanie A, Sun, Aiming, Steinhauer, David A, Luo, Ming, Moore, Martin L, Plemper, Richard K

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Tunable and reversible drug control of protein production via a self-excising degron by Chung, Hokyung K, Jacobs, Conor L, Huo, Yunwen, Yang, Jin, Krumm, Stefanie A, Plemper, Richard K, Tsien, Roger Y, Lin, Michael Z

“…SMASh is a strategy for regulating protein stability, in which treatment with a small molecule targets a protein tagged with a self-removing degron that…”
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Target Analysis of the Experimental Measles Therapeutic AS-136A by YOON, Jeong-Joong, KRUMM, Stefanie A, NDUNGU, J. Maina, HOFFMAN, Vanessa, BANKAMP, Bettina, ROTA, Paul A, AIMING SUN, SNYDER, James P, PLEMPER, Richard K

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The T-cell-directed vaccine BNT162b4 encoding conserved non-spike antigens protects animals from severe SARS-CoV-2 infection by Arieta, Christina M., Xie, Yushu Joy, Rothenberg, Daniel A., Diao, Huitian, Harjanto, Dewi, Meda, Shirisha, Marquart, Krisann, Koenitzer, Byron, Sciuto, Tracey E., Lobo, Alexander, Zuiani, Adam, Krumm, Stefanie A., Cadima Couto, Carla Iris, Hein, Stephanie, Heinen, André P., Ziegenhals, Thomas, Liu-Lupo, Yunpeng, Vogel, Annette B., Srouji, John R., Fesser, Stephanie, Thanki, Kaushik, Walzer, Kerstin, Addona, Theresa A., Türeci, Özlem, Şahin, Uğur, Gaynor, Richard B., Poran, Asaf

“…T cell responses play an important role in protection against beta-coronavirus infections, including SARS-CoV-2, where they associate with decreased COVID-19…”
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Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope by Doores, Katie J, Kong, Leopold, Krumm, Stefanie A, Le, Khoa M, Sok, Devin, Laserson, Uri, Garces, Fernando, Poignard, Pascal, Wilson, Ian A, Burton, Dennis R

“…The high-mannose patch of human immunodeficiency virus (HIV) envelope (Env) elicits broadly neutralizing antibodies (bnAbs) during natural infection relatively…”
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Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein by Behrens, Anna-Janina, Vasiljevic, Snezana, Pritchard, Laura K., Harvey, David J., Andev, Rajinder S., Krumm, Stefanie A., Struwe, Weston B., Cupo, Albert, Kumar, Abhinav, Zitzmann, Nicole, Seabright, Gemma E., Kramer, Holger B., Spencer, Daniel I.R., Royle, Louise, Lee, Jeong Hyun, Klasse, Per J., Burton, Dennis R., Wilson, Ian A., Ward, Andrew B., Sanders, Rogier W., Moore, John P., Doores, Katie J., Crispin, Max

“…The HIV-1 envelope glycoprotein trimer is covered by an array of N-linked glycans that shield it from immune surveillance. The high density of glycans on the…”
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Glycan Microheterogeneity at the PGT135 Antibody Recognition Site on HIV-1 gp120 Reveals a Molecular Mechanism for Neutralization Resistance by Pritchard, Laura K, Spencer, Daniel I R, Royle, Louise, Vasiljevic, Snezana, Krumm, Stefanie A, Doores, Katie J, Crispin, Max

“…Broadly neutralizing antibodies have been isolated that bind the glycan shield of the HIV-1 envelope spike. One such antibody, PGT135, contacts the intrinsic…”
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Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization by Zeltina, Antra, Krumm, Stefanie A., Sahin, Mehmet, Struwe, Weston B., Harlos, Karl, Nunberg, Jack H., Crispin, Max, Pinschewer, Daniel D., Doores, Katie J., Bowden, Thomas A.

“…Transmission of hemorrhagic fever New World arenaviruses from their rodent reservoirs to human populations poses substantial public health and economic…”
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The Tetrameric Plant Lectin BanLec Neutralizes HIV through Bidentate Binding to Specific Viral Glycans by Hopper, Jonathan T.S., Ambrose, Stephen, Grant, Oliver C., Krumm, Stefanie A., Allison, Timothy M., Degiacomi, Matteo T., Tully, Mark D., Pritchard, Laura K., Ozorowski, Gabriel, Ward, Andrew B., Crispin, Max, Doores, Katie J., Woods, Robert J., Benesch, Justin L.P., Robinson, Carol V., Struwe, Weston B.

“…Select lectins have powerful anti-viral properties that effectively neutralize HIV-1 by targeting the dense glycan shield on the virus. Here, we reveal the…”
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Mechanisms of escape from the PGT128 family of anti-HIV broadly neutralizing antibodies by Krumm, Stefanie A, Mohammed, Hajer, Le, Khoa M, Crispin, Max, Wrin, Terri, Poignard, Pascal, Burton, Dennis R, Doores, Katie J

“…Broadly neutralizing antibodies (bnAbs) directed against the mannose-patch on the HIV envelope glycoprotein gp120 have several features that make them…”
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