Search Results - "Krumm, Brian"

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor by Kim, Kuglae, Che, Tao, Panova, Ouliana, DiBerto, Jeffrey F., Lyu, Jiankun, Krumm, Brian E., Wacker, Daniel, Robertson, Michael J., Seven, Alpay B., Nichols, David E., Shoichet, Brian K., Skiniotis, Georgios, Roth, Bryan L.

“…Hallucinogens like lysergic acid diethylamide (LSD), psilocybin, and substituted N-benzyl phenylalkylamines are widely used recreationally with psilocybin…”
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TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome by Olsen, Reid H. J., DiBerto, Jeffrey F., English, Justin G., Glaudin, Alexis M., Krumm, Brian E., Slocum, Samuel T., Che, Tao, Gavin, Ariana C., McCorvy, John D., Roth, Bryan L., Strachan, Ryan T.

“…G-protein-coupled receptors (GPCRs) remain major drug targets, despite our incomplete understanding of how they signal through 16 non-visual G-protein signal…”
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Molecular glues as potential GPCR therapeutics by Roth, Bryan L., Krumm, Brian E.

“…[Display omitted] “Molecular Glues” are defined as small molecules that can either be endogenous or synthetic which promote interactions between proteins at…”
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Molecular mechanism of biased signaling at the kappa opioid receptor by El Daibani, Amal, Paggi, Joseph M., Kim, Kuglae, Laloudakis, Yianni D., Popov, Petr, Bernhard, Sarah M., Krumm, Brian E., Olsen, Reid H. J., Diberto, Jeffrey, Carroll, F. Ivy, Katritch, Vsevolod, Wünsch, Bernhard, Dror, Ron O., Che, Tao

“…The κ-opioid receptor (KOR) has emerged as an attractive drug target for pain management without addiction, and biased signaling through particular pathways of…”
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Structural prerequisites for G-protein activation by the neurotensin receptor by Krumm, Brian E., White, Jim F., Shah, Priyanka, Grisshammer, Reinhard

“…We previously determined the structure of neurotensin receptor NTSR1 in an active-like conformation with six thermostabilizing mutations bound to the peptide…”
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Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor by Che, Tao, Majumdar, Susruta, Zaidi, Saheem A., Ondachi, Pauline, McCorvy, John D., Wang, Sheng, Mosier, Philip D., Uprety, Rajendra, Vardy, Eyal, Krumm, Brian E., Han, Gye Won, Lee, Ming-Yue, Pardon, Els, Steyaert, Jan, Huang, Xi-Ping, Strachan, Ryan T., Tribo, Alexandra R., Pasternak, Gavril W., Carroll, F. Ivy, Stevens, Raymond C., Cherezov, Vadim, Katritch, Vsevolod, Wacker, Daniel, Roth, Bryan L.

“…The κ-opioid receptor (KOP) mediates the actions of opioids with hallucinogenic, dysphoric, and analgesic activities. The design of KOP analgesics devoid of…”
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Structure, function and pharmacology of human itch GPCRs by Cao, Can, Kang, Hye Jin, Singh, Isha, Chen, He, Zhang, Chengwei, Ye, Wenlei, Hayes, Byron W., Liu, Jing, Gumpper, Ryan H., Bender, Brian J., Slocum, Samuel T., Krumm, Brian E., Lansu, Katherine, McCorvy, John D., Kroeze, Wesley K., English, Justin G., DiBerto, Jeffrey F., Olsen, Reid H. J., Huang, Xi-Ping, Zhang, Shicheng, Liu, Yongfeng, Kim, Kuglae, Karpiak, Joel, Jan, Lily Y., Abraham, Soman N., Jin, Jian, Shoichet, Brian K., Fay, Jonathan F., Roth, Bryan L.

“…The MRGPRX family of receptors (MRGPRX1–4) is a family of mas-related G-protein-coupled receptors that have evolved relatively recently 1 . Of these, MRGPRX2…”
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Nanobody-enabled monitoring of kappa opioid receptor states by Che, Tao, English, Justin, Krumm, Brian E., Kim, Kuglae, Pardon, Els, Olsen, Reid H. J., Wang, Sheng, Zhang, Shicheng, Diberto, Jeffrey F., Sciaky, Noah, Carroll, F. Ivy, Steyaert, Jan, Wacker, Daniel, Roth, Bryan L.

“…Recent studies show that GPCRs rapidly interconvert between multiple states although our ability to interrogate, monitor and visualize them is limited by a…”
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Molecular basis for selective activation of DREADD-based chemogenetics by Zhang, Shicheng, Gumpper, Ryan H., Huang, Xi-Ping, Liu, Yongfeng, Krumm, Brian E., Cao, Can, Fay, Jonathan F., Roth, Bryan L.

“…Designer receptors exclusively activated by designer drugs (DREADDs) represent a powerful chemogenetic technology for the remote control of neuronal activity…”
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Structures of the human dopamine D3 receptor-Gi complexes by Xu, Peiyu, Huang, Sijie, Mao, Chunyou, Krumm, Brian E., Zhou, X. Edward, Tan, Yangxia, Huang, Xi-Ping, Liu, Yongfeng, Shen, Dan-Dan, Jiang, Yi, Yu, Xuekui, Jiang, Hualiang, Melcher, Karsten, Roth, Bryan L., Cheng, Xi, Zhang, Yan, Xu, H. Eric

“…The dopamine system, including five dopamine receptors (D1R–D5R), plays essential roles in the central nervous system (CNS), and ligands that activate dopamine…”
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Structural biology of the IL‐1 superfamily: Key cytokines in the regulation of immune and inflammatory responses by Krumm, Brian, Xiang, Yan, Deng, Junpeng

“…Interleukin‐1 superfamily of cytokines (IL‐1, IL‐18, IL‐33) play key roles in inflammation and regulating immunity. The mechanisms of agonism and antagonism in…”
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Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD by Cao, Can, Barros-Álvarez, Ximena, Zhang, Shicheng, Kim, Kuglae, Dämgen, Marc A, Panova, Ouliana, Suomivuori, Carl-Mikael, Fay, Jonathan F, Zhong, Xiaofang, Krumm, Brian E, Gumpper, Ryan H, Seven, Alpay B, Robertson, Michael J, Krogan, Nevan J, Hüttenhain, Ruth, Nichols, David E, Dror, Ron O, Skiniotis, Georgios, Roth, Bryan L

“…Serotonin (5-hydroxytryptamine [5-HT]) 5-HT2-family receptors represent essential targets for lysergic acid diethylamide (LSD) and all other psychedelic drugs…”
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Ligand and G-protein selectivity in the κ-opioid receptor by Han, Jianming, Zhang, Jingying, Nazarova, Antonina L., Bernhard, Sarah M., Krumm, Brian E., Zhao, Lei, Lam, Jordy Homing, Rangari, Vipin A., Majumdar, Susruta, Nichols, David E., Katritch, Vsevolod, Yuan, Peng, Fay, Jonathan F., Che, Tao

“…The κ-opioid receptor (KOR) represents a highly desirable therapeutic target for treating not only pain but also addiction and affective disorders 1 . However,…”
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Structure and dynamics of a constitutively active neurotensin receptor by Krumm, Brian E., Lee, Sangbae, Bhattacharya, Supriyo, Botos, Istvan, White, Courtney F., Du, Haijuan, Vaidehi, Nagarajan, Grisshammer, Reinhard

“…Many G protein-coupled receptors show constitutive activity, resulting in the production of a second messenger in the absence of an agonist; and naturally…”
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Ligand recognition and allosteric modulation of the human MRGPRX1 receptor by Liu, Yongfeng, Cao, Can, Huang, Xi-Ping, Gumpper, Ryan H., Rachman, Moira M., Shih, Sheng-Luen, Krumm, Brian E., Zhang, Shicheng, Shoichet, Brian K., Fay, Jonathan F., Roth, Bryan L.

“…The human MAS-related G protein–coupled receptor X1 (MRGPRX1) is preferentially expressed in the small-diameter primary sensory neurons and involved in the…”
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Bitter taste receptor activation by cholesterol and an intracellular tastant by Kim, Yoojoong, Gumpper, Ryan H., Liu, Yongfeng, Kocak, D. Dewran, Xiong, Yan, Cao, Can, Deng, Zhijie, Krumm, Brian E., Jain, Manish K., Zhang, Shicheng, Jin, Jian, Roth, Bryan L.

“…Bitter taste sensing is mediated by type 2 taste receptors (TAS2Rs (also known as T2Rs)), which represent a distinct class of G-protein-coupled receptors 1 …”
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Identification of small molecule inhibitors of Interleukin-18 by Krumm, Brian, Meng, Xiangzhi, Xiang, Yan, Deng, Junpeng

“…Interleukin-18 (IL-18) is a pleiotropic pro-inflammatory cytokine belonging to the IL-1 superfamily. IL-18 plays an important role in host innate and adaptive…”
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Inactive and active state structures template selective tools for the human 5-HT5A receptor by Zhang, Shicheng, Chen, He, Zhang, Chengwei, Yang, Ying, Popov, Petr, Liu, Jing, Krumm, Brian E., Cao, Can, Kim, Kuglae, Xiong, Yan, Katritch, Vsevolod, Shoichet, Brian K., Jin, Jian, Fay, Jonathan F., Roth, Bryan L.

“…Serotonin receptors are important targets for established therapeutics and drug development as they are expressed throughout the human body and play key roles…”
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Structural genomics of the human dopamine receptor system by Xu, Peiyu, Huang, Sijie, Krumm, Brian E., Zhuang, Youwen, Mao, Chunyou, Zhang, Yumu, Wang, Yue, Huang, Xi-Ping, Liu, Yong-Feng, He, Xinheng, Li, Huadong, Yin, Wanchao, Jiang, Yi, Zhang, Yan, Roth, Bryan L., Xu, H. Eric

“…The dopaminergic system, including five dopamine receptors (D1R to D5R), plays essential roles in the central nervous system (CNS); and ligands that activate…”
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Author Correction: Bitter taste receptor activation by cholesterol and an intracellular tastant by Kim, Yoojoong, Gumpper, Ryan H., Liu, Yongfeng, Kocak, D. Dewran, Xiong, Yan, Cao, Can, Deng, Zhijie, Krumm, Brian E., Jain, Manish K., Zhang, Shicheng, Jin, Jian, Roth, Bryan L.

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