Search Results - "Kruman, Inna I."

Differential sensitivity of prefrontal cortex and hippocampus to alcohol-induced toxicity by Fowler, Anna-Kate, Thompson, Jeremy, Chen, Lixia, Dagda, Marisela, Dertien, Janet, Dossou, Katina Sylvestre S, Moaddel, Ruin, Bergeson, Susan E, Kruman, Inna I

“…The prefrontal cortex (PFC) is a brain region responsible for executive functions including working memory, impulse control and decision making. The loss of…”
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Cell Cycle Activation Linked to Neuronal Cell Death Initiated by DNA Damage by Kruman, Inna I, Wersto, Robert P, Cardozo-Pelaez, Fernando, Smilenov, Lubomir, Chan, Sic L, Chrest, Francis J, Emokpae, Roland, Gorospe, Myriam, Mattson, Mark P

“…Increasing evidence indicates that neurodegeneration involves the activation of the cell cycle machinery in postmitotic neurons. However, the purpose of these…”
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Folic Acid Deficiency and Homocysteine Impair DNA Repair in Hippocampal Neurons and Sensitize Them to Amyloid Toxicity in Experimental Models of Alzheimer's Disease by Kruman, Inna I, Kumaravel, T. S, Lohani, Althaf, Pedersen, Ward A, Cutler, Roy G, Kruman, Yuri, Haughey, Norman, Lee, Jaewon, Evans, Michele, Mattson, Mark P

“…Recent epidemiological and clinical data suggest that persons with low folic acid levels and elevated homocysteine levels are at increased risk of Alzheimer's…”
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Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease by Duan, Wenzhen, Ladenheim, Bruce, Cutler, Roy G., Kruman, Inna I., Cadet, Jean Lud, Mattson, Mark P.

“…Although the cause of Parkinson's disease (PD) is unknown, data suggest roles for environmental factors that may sensitize dopaminergic neurons to age‐related…”
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Folate deficiency inhibits proliferation of adult hippocampal progenitors by Kruman, Inna I, Mouton, Peter R, Emokpae, Roland, Cutler, Roy G, Mattson, Mark P

“…Neurogenesis in the adult hippocampus may play important roles in learning and memory, and in recovery from injury. As recent findings suggest, the perturbance…”
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Cell Cycle Activation in Postmitotic Neurons is Essential for DNA Repair by Schwartz, Elena I., Smilenov, Lubomir B., Price, Mary A., Osredkar, Tracy, Baker, Ronald A., Ghosh, Soma, Shi, Fu-Dong, Vollmer, Timothy L., Lencinas, Alejandro, Stearns, Diane M., Gorospe, Myriam, Kruman, Inna I.

“…Increasing evidence indicates that maintenance of neuronal homeostasis involves theactivation of the cell cycle machinery in postmitotic neurons. Our recent…”
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DNA damage response and neuroprotection by Kruman, Inna I, Schwartz, Elena I

“…The protection of genomic integrity is a major challenge for living cells that are continuously exposed to endogenous and environmental DNA-damaging insults…”
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Impaired one carbon metabolism and DNA methylation in alcohol toxicity by Kruman, Inna I., Fowler, Anna‐Kate

“…Excessive alcohol consumption is a prominent problem and one of the major causes of mortality and morbidity around the world. Long‐term, heavy alcohol…”
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Suppression of Uracil-DNA Glycosylase Induces Neuronal Apoptosis by Kruman, Inna I, Schwartz, Elena, Kruman, Yuri, Cutler, Roy G, Zhu, Xiaoxiang, Greig, Nigel H, Mattson, Mark P

“…A chronic imbalance in DNA precursors, caused by one-carbon metabolism impairment, can result in a deficiency of DNA repair and increased DNA damage. Although…”
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DNA damage and neurotoxicity of chronic alcohol abuse by Kruman, Inna I, Henderson, George I, Bergeson, Susan E

“…Chronic alcohol abuse results in a variety of pathological effects including damage to the brain. The causes of alcohol-induced brain pathology are presently…”
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Why do Neurons Enter the Cell Cycle? by Kruman, Inna I.

“…Increasing evidence indicates that postmitotic, terminally differentiated neurons activate the cell cycle before death. The purpose of this cell cycle…”
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Homocysteine Elicits a DNA Damage Response in Neurons That Promotes Apoptosis and Hypersensitivity to Excitotoxicity by Kruman, Inna I, Culmsee, Carsten, Chan, Sic L, Kruman, Yuri, Guo, Zhihong, Penix, LaRoy, Mattson, Mark P

“…Elevated plasma levels of the sulfur-containing amino acid homocysteine increase the risk for atherosclerosis, stroke, and possibly Alzheimer's disease, but…”
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Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes by Myung, Na-Hye, Zhu, Xiongwei, Kruman, Inna I., Castellani, Rudy J., Petersen, Robert B., Siedlak, Sandra L., Perry, George, Smith, Mark A., Lee, Hyoung-gon

“…Phosphorylation of the histone family is not only a response to cell signaling stimuli, but also an important indicator of DNA damage preceding apoptotic…”
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Alcohol-induced One-carbon Metabolism Impairment Promotes Dysfunction of DNA Base Excision Repair in Adult Brain by Fowler, Anna-Kate, Hewetson, Aveline, Agrawal, Rajiv G., Dagda, Marisela, Dagda, Raul, Moaddel, Ruin, Balbo, Silvia, Sanghvi, Mitesh, Chen, Yukun, Hogue, Ryan J., Bergeson, Susan E., Henderson, George I., Kruman, Inna I.

“…The brain is one of the major targets of chronic alcohol abuse. Yet the fundamental mechanisms underlying alcohol-mediated brain damage remain unclear. The…”
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Pivotal Role of Mitochondrial Calcium Uptake in Neural Cell Apoptosis and Necrosis by Kruman, Inna I., Mattson, Mark P.

“…: Perturbed cellular calcium homeostasis has been implicated in both apoptosis and necrosis, but the role of altered mitochondrial calcium handling in the cell…”
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Folic acid and homocysteine in age-related disease by Mattson, Mark P, Kruman, Inna I, Duan, Wenzhen

“…It has been known for decades that babies born to women that have a dietary deficiency in folic acid (folate) are at increased risk for birth defects, and that…”
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ALS-Linked Cu/Zn–SOD Mutation Increases Vulnerability of Motor Neurons to Excitotoxicity by a Mechanism Involving Increased Oxidative Stress and Perturbed Calcium Homeostasis by Kruman, Inna I., Pedersen, Ward A., Springer, Joe E., Mattson, Mark P.

“…We employed a mouse model of ALS, in which overexpression of a familial ALS-linked Cu/Zn–SOD mutation leads to progressive MN loss and a clinical phenotype…”
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Evidence that Par-4 Participates in the Pathogenesis of HIV Encephalitis by Kruman, Inna I., Nath, Avindra, Maragos, William F., Chan, Sic L., Jones, Melina, Rangnekar, Vivek M., Jakel, Rebekah J., Mattson, Mark P.

“…Progressive neuronal degeneration in brain regions involved in learning and memory processes is a common occurrence in patients infected with human…”
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Why do neurons enter the cell cycle? by Kruman, Inna I

“…Increasing evidence indicates that postmitotic, terminally differentiated neurons activate the cell cycle before death. The purpose of this cell cycle…”
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HIV-1 Protein Tat Induces Apoptosis of Hippocampal Neurons by a Mechanism Involving Caspase Activation, Calcium Overload, and Oxidative Stress by Kruman, Inna I., Nath, Avindra, Mattson, Mark P.

“…Patients infected with HIV-1 often exhibit cognitive deficits that are related to progressive neuronal degeneration and cell death. The protein Tat, which is…”
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