Misclassification of self‐reported smoking in adult survivors of childhood cancer

We investigated misclassification rates, sensitivity, and specificity of self‐reported cigarette smoking through serum cotinine concentration (liquid chromatography tandem mass spectrometry) among 287 adult survivors of childhood cancer. Overall, 2.5–6.7% and 19.7–36.9% of the self‐reported never an...

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Bibliographic Details
Published in:	Pediatric blood & cancer Vol. 65; no. 9; pp. e27240 - n/a
Main Authors:	Huang, I‐Chan, Klosky, James L., Young, Chelsea M., Murphy, Sharon E., Krull, Kevin K., Srivastava, DeoKumar, Hudson, Melissa M., Robison, Leslie L.
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01-09-2018
Subjects:	Adolescent Adult Biomarkers Cancer Cannabis childhood cancer survivors, cigarette smoking, cotinine Children Cigarette smoking Cotinine Cotinine - blood False Negative Reactions False Positive Reactions Female Health risk assessment Hematology Humans Liquid chromatography Male Marijuana Smoking - blood Marijuana Smoking - epidemiology Mass spectrometry Mass spectroscopy Middle Aged misclassification, tobacco use Oncology Pediatrics Self Report Sensitivity Sensitivity and Specificity Smoking Smoking - blood Smoking - epidemiology Smoking - psychology Surveys and Questionnaires Survivors - psychology Survivors - statistics & numerical data Tobacco Truth Disclosure Young Adult childhood cancer survivors, cigarette smoking, cotinine misclassification, tobacco use
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Summary:	We investigated misclassification rates, sensitivity, and specificity of self‐reported cigarette smoking through serum cotinine concentration (liquid chromatography tandem mass spectrometry) among 287 adult survivors of childhood cancer. Overall, 2.5–6.7% and 19.7–36.9% of the self‐reported never and past smokers had cotinine levels indicative of active smoking. Sensitivity and specificity of self‐reported smoking were 57.5–67.1% and 96.6–99.2%. Misclassification was associated with younger age (OR = 3.2; 95% CI = 1.4–7.4), male (OR = 2.1; 95% CI = 1.1–4.0), and past (OR = 2.7; 95% CI = 1.3–5.8) or current (OR = 2.6; 95% CI = 1.0–6.6) marijuana use. After adjusting for tobacco‐related variables, current marijuana use remained a significant risk for misclassification. Clinicians/researchers should consider bio‐verification to measure smoking status among survivors.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1545-5009 1545-5017
DOI:	10.1002/pbc.27240