Search Results - "Krull, I S"

Characterization of Noncovalent Complexes of Recombinant Human Monoclonal Antibody and Antigen Using Cation Exchange, Size Exclusion Chromatography, and BIAcore by Santora, L.C., Kaymakcalan, Z., Sakorafas, P., Krull, I.S., Grant, K.

“…The binding of fully human monoclonal antibodies (MAbs) D2E7 and 2SD4 to their antigen, human tumor necrosis factor-α (TNFα), was investigated by BIAcore,…”
Get full text

Characterization of Recombinant Human Monoclonal Tissue Necrosis Factor-α Antibody Using Cation-Exchange HPLC and Capillary Isoelectric Focusing by Santora, L.C., Krull, I.S., Grant, K.

“…Cation-exchange liquid chromatography (CIEX) and capillary isoelectric focusing (cIEF) methods have been developed for the routine analysis of a recombinant,…”
Get full text

Specific applications of capillary electrochromatography to biopolymers, including proteins, nucleic acids, peptide mapping, antibodies, and so forth by Krull, I.S., Sebag, A., Stevenson, R.

“…Separation of biopolymers is an obvious application of capillary electrochromatography (CEC) technology, since speed and resolution should increase…”
Get full text

Labeling reactions applicable to chromatography and electrophoresis of minute amounts of proteins by Krull, I.S., Strong, R., Sosic, Z., Cho, B.-Y., Beale, S.C., Wang, C.-C., Cohen, S.

“…Chromatography and electrophoresis have become extremely valuable and important methods for the separation, purification, detection and analysis of biopolymers…”
Get full text

Capillary isoelectric focusing as a tool in the examination of antibodies, peptides and proteins of pharmaceutical interest by Liu, X., Sosic, Z., Krull, I.S.

“…This paper describes the recent history and development of capillary isoelectric focusing (cIEF), as it has evolved over the past 10 years forming a distinct…”
Get full text

Characterization of antigen-antibody complexes by size-exclusion chromatography coupled with low-angle light-scattering photometry and viscometry by Qian, R.L., Mhatre, R., Krull, I.S.

“…In this paper, the molecular masses ( M rs) of the complexes of monoclonal anti-BSA (antibody to bovine serum albumin) (clone: 33) and monomer BSA were…”
Get full text

HPCE methods for the identification and quantitation of antibodies, their conjugates and complexes by Krull, I.S., Liu, X., Dai, J., Gendreau, C., Li, G.

“…We review here much of the existing literature that deals with analysis, resolution, characterization, and (at times) quantitation of antibodies in capillary…”
Get full text

Thermal stability studies of immunoglobulins using capillary isoelectric focusing and capillary zone electrophoretic methods by Dai, H.J., Krull, I.S.

“…The affinity of an antibody towards its antigen is highly specific to its conformation, in order to have optimal antibody–antigen interaction. The increase of…”
Get full text

Coated capillaries and additives for the separation of proteins by capillary zone electrophoresis and capillary isoelectric focusing by Mazzeo, J R, Krull, I S

“…Strategies reported for the separation of proteins in capillary zone electrophoresis and capillary isoelectric focusing are reviewed. The strategies are…”
Get more information

Improved detection and derivatization in capillary electrophoresis by Szulc, M E, Krull, I S

“…Capillary electrophoresis is well known for its low mass detectabilities, but suffers from poor concentration detection limits. This review will discuss…”
Get more information

Homogeneous Preparation of Fluorescent-Derivatized Insulin and Its Application to Competitive Chromatographic Immunoassays by Liu, H.-J., Strong, R.E., Krull, I.S., Cohen, S.A.

“…A homogeneously labeled insulin sample was prepared using 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) as the fluorescent-labeling reagent, and this…”
Get full text

Peptide mapping using EOF-driven capillary isoelectric focusing by Mazzeo, J R, Martineau, J A, Krull, I S

“…Capillary isoelectric focusing (CIEF) in uncoated and commercially available coated capillaries was applied to the separation of tryptic peptides from bovine…”
Get more information

9-Fluoreneacetyl-tagged, solid-phase reagent for derivatization in direct plasma injection by Zhou, F X, Krull, I S, Feibush, B

“…We describe here a resin-based derivatization reagent, containing a 9-fluoreneacetyl tag on a controlled-pore substrate, for direct injection analysis of…”
Get more information

Separation and quantitation of monoclonal antibodies in cell growth medium using capillary zone electrophoresis by Dai, H.J, Li, G, Krull, I.S

“…IgG1 is separated from its impurities in cell growth medium under simple CZE conditions without specific sample pretreatment. Linearity, limit of quantitation,…”
Get full text

Electrochemical activity of 6-aminoquinolyl urea derivatives of amino acids and peptides. Application to high-performance liquid chromatography with electrochemical detection by Li, G.-D., Krull, I.S., Cohen, S.A.

“…6-Aminoquinolyl-N-hydroxysuccinimidyl carbamate (6-AQC) is a reagent used to increase the detection-sensitivity of amino acids and peptides in high-performance…”
Get full text

Direct enantiomeric analysis of amphetamine in plasma by simultaneous solid phase extraction and chiral derivatization by ZHOU, F.-X, KRULL, I. S

“…An analytical approach has been developed for the one step determination of enantiomeric amphetamine composition in plasma, using on-line, pre-column solid…”
Get full text

Stabilization of reactive species within polystyrene divinylbenzene polymer networks by Bourque, A. J, Krull, I. S, Feibush, B

“…The effect of cross-linking, surface area, and porous nature of modified polystyrene-divinylbenzene (STY-DVB) reagents has been investigated. The supports were…”
Get full text

Determination of aromatic and sulfur-containing amino acids, peptides, and proteins using high-performance liquid chromatography with photolytic electrochemical detection by Dou, Lin, Krull, Ira S

“…Aromatic amino acids, sulfur-containing amino acids, peptides containing such constituents, and proteins can now be detected in high-performance liquid…”
Get full text

Characterization of maleuric acid derivatives on transgenic human monoclonal antibody due to post-secretional modifications in goat milk by Santora, L. C., Stanley, K., Krull, I. S., Grant, K.

“…A fully human antibody to tumor necrosis factor‐α was expressed in the mammary glands of transgenic goats. The goat expressed antibody (gAb) is heterogeneous…”
Get full text

Determination of biopolymer (protein) molecular weights by gradient elution, reversed-phase high-performance liquid chromatography with low-angle laser light scattering detection by Mhatre, R, Krull, I S, Stuting, H H

“…The determination of molecular weights for certain proteins has been performed. This has involved the on-line coupling of gradient elution, reversed-phase…”
Get more information