Search Results - "Kruk, Patricia A"

MicroRNA Expression Profiling in Human Ovarian Cancer : miR-214 Induces Cell Survival and Cisplatin Resistance by Targeting PTEN by HUA YANG, KONG, William, CHENG, Jin Q, LILI HE, ZHAO, Jian-Jun, O'DONNELL, Joshua D, JIAWANG WANG, WENHAM, Robert M, COPPOLA, Domenico, KRUK, Patricia A, NICOSIA, Santo V

“…MicroRNAs (miRNA) represent a novel class of genes that function as negative regulators of gene expression. Recently, miRNAs have been implicated in several…”
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Increased RHAMM expression relates to ovarian cancer progression by Buttermore, Stephanie T, Hoffman, Mitchel S, Kumar, Ambuj, Champeaux, Anne, Nicosia, Santo V, Kruk, Patricia A

“…Elevated hyaluronan-mediated motility receptor (RHAMM) has been reported to contribute to disease progression, aggressive phenotype and poor prognosis in…”
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Aurora-A kinase regulates telomerase activity through c-Myc in human ovarian and breast epithelial cells by HUA YANG, CHIEN CHEN OU, FELDMAN, Richard I, NICOSIA, Santo V, KRUK, Patricia A, CHENG, Jin Q

“…Aurora-A kinase is frequently overexpressed/activated in human ovarian and breast cancers. A rat mammary tumor model study indicates that alterations of…”
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VEGF- and LPA-induced telomerase in human ovarian cancer cells is Sp1-dependent by Bermudez, Yira, Yang, Hua, Saunders, Beatriz O, Cheng, Jin Q, Nicosia, Santo V, Kruk, Patricia A

“…Abstract Objective. Both vascular endothelial growth factor (VEGF) and lysophosphatidic acid (LPA) are secreted by ovarian cancer cells and are known to…”
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Vitamin E suppresses telomerase activity in ovarian cancer cells by Bermudez, Yira, MS, Ahmadi, Shirrin, BS, Lowell, Nancy E., MS, Kruk, Patricia A., PhD

“…Abstract Background : Dietary factors influence tumor formation and progression. Vitamin E is a dietary anti-oxidant capable of eliminating free radical…”
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MicroRNA MiR-214 Regulates Ovarian Cancer Cell Stemness by Targeting p53/Nanog by Xu, Cheng-Xiong, Xu, Meng, Tan, Lei, Yang, Hua, Permuth-Wey, Jennifer, Kruk, Patricia A., Wenham, Robert M., Nicosia, Santo V., Lancaster, Johnathan M., Sellers, Thomas A., Cheng, Jin Q.

“…Previous studies have shown aberrant expression of miR-214 in human malignancy. Elevated miR-214 is associated with chemoresistance and metastasis. In this…”
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Bcl-2 expression is altered with ovarian tumor progression: an immunohistochemical evaluation by Anderson, Nicole S, Turner, Leslie, Livingston, Sandra, Chen, Ren, Nicosia, Santo V, Kruk, Patricia A

“…Ovarian cancer is the most lethal gynecologic malignancy. The ovarian tumor microenvironment is comprised of tumor cells, surrounding stroma, and circulating…”
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Ovarian Epithelial-Stromal Interactions: Role of Interleukins 1 and 6 by Woolery, Kamisha T., Kruk, Patricia A.

“…Ovarian epithelial cancer is the most lethal gynecologic malignancy. The high mortality is attributed to the fact that most cases typically present in late…”
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BRCA1 16 years later: risk-associated BRCA1 mutations and their functional implications by Linger, Rebecca J, Kruk, Patricia A

“…Mutations in the tumor suppressor breast cancer susceptibility gene 1 (BRCA1), an important player in the DNA damage response, apoptosis, cell cycle regulation…”
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Procurement and cytological features of human fallopian tube fimbrial cells by ex vivo imprinting and washing by Dobrinski, Kimberly, PhD, Esposito, Nicole N., MD, Kruk, Patricia A., PhD, Wenham, Robert, MD, Hoffman, Mitchell, MD, Coppola, Domenico, MD, Bai, Wenlong, PhD, Zhang, Xiaohong, PhD, Siddique, Nikhut, BS, Nicosia, Santo V., MD

“…Introduction Fallopian tube intraepithelial cancer is a postulated precursor of epithelial ovarian carcinomas. As research continues on epithelial ovarian…”
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MicroRNA MiR-214 regulates ovarian cancer cell stemness by targeting p53/Nanog by Xu, Cheng-Xiong, Xu, Meng, Tan, Lei, Yang, Hua, Permuth-Wey, Jennifer, Kruk, Patricia A., Wenham, Robert M., Nicosia, Santo V., Lancaster, Johnathan M., Sellers, Thomas A., Cheng, Jin Q.

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Deregulation of IKBKE Is Associated with Tumor Progression, Poor Prognosis, and Cisplatin Resistance in Ovarian Cancer by Guo, Jian-Ping, Shu, Shao-Kun, He, Lili, Lee, Yi-Chun, Kruk, Patricia A, Grenman, Seija, Nicosia, Santo V, Mor, Gil, Schell, Michael J, Coppola, Domenico, Cheng, Jin Q

“…I-kappa-B kinase e (IKBKE; IKKϵ) has been recently identified as a breast cancer oncogene, and its alteration appears to be an early event in breast cancer…”
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Expression of Semaphorin 3F and Its Receptors in Epithelial Ovarian Cancer, Fallopian Tubes, and Secondary Müllerian Tissues by Drenberg, Christina D., Livingston, Sandra, Chen, Ren, Kruk, Patricia A., Nicosia, Santo V.

“…While semaphorins and their receptors appear to play a role in tumor carcinogenesis, little is known about the role of semaphorin 3F (S3F) in epithelial…”
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BRCA1 185delAG Mutation Enhances Interleukin-1β Expression in Ovarian Surface Epithelial Cells by Roman, Jesse, Dobrinski, Kimberly P., Linger, Rebecca J., Mohamed, Mai, Woolery, Kamisha T., Kruk, Patricia A.

“…Familial history remains the strongest risk factor for developing ovarian cancer (OC) and is associated with germline BRCA1 mutations, such as the 185delAG…”
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Urinary levels of Bcl-2 are elevated in ovarian cancer patients by Anderson, Nicole S, Bermudez, Yira, Badgwell, Donna, Chen, Ren, Nicosia, Santo V, Bast, Robert C, Kruk, Patricia A

“…Abstract Objective(s) The poor prognosis associated with ovarian cancer is due to the lack of overt early symptoms and the absence of reliable diagnostic…”
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BRCA1 185delAG mutant protein, BRAt, up-regulates maspin in ovarian epithelial cells by O'Donnell, Joshua D, Linger, Rebecca J, Kruk, Patricia A

“…Abstract Objective Aggressive clinical course and difficult detection of ovarian cancer are major challenges to improving patient survival and necessitate avid…”
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BRCA1 Zinc RING Finger Domain Disruption Alters Caspase Response in Ovarian Surface Epithelial Cells by Johnson, Nicole C, Kruk, Patricia A

“…BACKGROUND: The frequently occurring 185delAG mutation occurs in the amino-terminal zinc RING domain of the breast and ovarian cancer susceptibility gene,…”
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Urinary interleukin-1β levels among gynecological patients by Woolery, Kamisha T, Hoffman, Mitchel S, Kraft, Joshua, Nicosia, Santo V, Kumar, Ambuj, Kruk, Patricia A

“…Early detection of epithelial ovarian cancer (OC) is necessary to overcome the high mortality rate of late stage diagnosis; and, examining the molecular…”
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Urinary angiostatin levels are elevated in patients with epithelial ovarian cancer by Drenberg, Christina D, Saunders, Beatriz O, Wilbanks, George D, Chen, Ren, Nicosia, Roberto F, Kruk, Patricia A, Nicosia, Santo V

“…Abstract Objective The poor prognosis associated with epithelial ovarian cancer (EOC) is due to the lack of overt early symptoms and the absence of reliable…”
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Pyk2/ERK 1/2 mediate Sp1- and c-Myc-dependent induction of telomerase activity by epidermal growth factor by Bermudez, Yira, Yang, Hua, Cheng, Jin Q., Kruk, Patricia A.

“…Epidermal growth factor (EGF) promotes growth of normal ovarian surface as well as malignant ovarian epithelial cells. Further, EGF receptors are present on…”
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